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Parke Sneha A.; Birch Gordon G.; MacDougall Douglas B.; Stevens David A. 《Chemical senses》1997,22(1):53-65
D-glucono-1,5-lactone differs from D-glucopyranose only in thatit has a C=O group instead of CHOH group at carbon atom numberone. The molecule therefore possesses an intact 3,4 相似文献
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A facile synthesis of dl-6,10,14-trimethylpentadecan-2-ol (1) a pheromone component of rice moth, Corcyra cephalonica Stainton and 5,9,13-trimethyltetradecanoic acid (2) a component of marine sponge, Cinachyrella alloclada Uliczka, using a common intermediate, hexahydrofarnesol is accomplished. The salient features for 1 are: Grignard coupling of 5 with allylmagnesium bromide and oxymercuration-demercuration whereas for 2 they are: Knoevenagel condensation and subsequent hydrogenation. 相似文献
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D. Thirumal Kumar P. Sneha Iftikhar Aslam Tayubi R. Siva Chiranjib Chakraborty 《Journal of biomolecular structure & dynamics》2017,35(5):917-928
Recent genetic studies have revealed the impact of mutations in associated genes for cardiac sarcomere components leading to dilated cardiomyopathy (DCM). The cardiac sarcomere is composed of thick and thin filaments and a giant muscle protein known as titin or connectin. Titin interacts with T-cap/telethonin in the Z-line region and plays a vital role in regulating sarcomere assembly. Initially, we screened all the variants associated with giant protein titin and analyzed their impact with the aid of pathogenicity and stability prediction methods. V54M mutation found in the hydrophobic core region of the protein associated with abnormal clinical phenotype leads to DCM was selected for further analysis. To address this issue, we mapped the deleterious mutant V54M, modeled the mutant protein complex, and deciphered the impact of mutation on binding with its partner telethonin in the titin crystal structure of PDB ID: 1YA5 with the aid of docking analysis. Furthermore, two run molecular dynamics simulation was initiated to understand the mechanistic action of V54M mutation in altering the protein structure, dynamics, and stability. According to the results obtained from the repeated 50 ns trajectory files, the overall effect of V54M mutation was destabilizing and transition of bend to coil in the secondary structure was observed. Furthermore, MMPBSA elucidated that V54M found in the Z-line region of titin decreases the binding affinity of titin to Z-line proteins T-cap/telethonin thereby hindering the protein–protein interaction. 相似文献
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Molecular Modeling and Dynamic Simulation of Arabidopsis Thaliana Carotenoid Cleavage Dioxygenase Gene: A Comparison with Bixa orellana and Crocus Sativus
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Kamala K. Vasu Chander Singh Digwal Amit N. Pandya Dhaivat H. Pandya Jayesh A. Sharma Sneha Patel Milee Agarwal 《Bioorganic & medicinal chemistry letters》2017,27(24):5463-5466
A series of new imidazo[1,2-a]pyridine linked with thiazole/thiophene motif through a keto spacer were synthesized and tested for their cytotoxic potential against three human cancer cell lines including A549, HeLa and U87-MG using MTT assay. Compounds A2, A3, A4, C1 and C2 showed cytotoxicity against all the three cell lines. The selectivity index for compound A4 for A549 and HeLa cells was comparable to that of doxorubicin. Among the synthesized compounds, B5 showed the maximum inhibition of NF-κB activity as ascertained by NF-κB reporter assay (IC50?=?6.5?±?0.6?µM). Treatment of NCI-H23 cells (EGFR overexpressed, KRAS G12V mutant) with erlotinib and gefitinib along with compounds A4 and B5 indicated synergistic and additive potential of combination therapy. 相似文献
127.
Solanum tuberosum StCDPK1 is regulated by miR390 at the posttranscriptional level and phosphorylates the auxin efflux carrier StPIN4 in vitro,a potential downstream target in potato development
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Franco Santin Sneha Bhogale Elisa Fantino Anjan K. Banerjee Rita M. Ulloa 《Physiologia plantarum》2017,159(2):244-261
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