面向国家公园管理目标的综合灾害风险管理:一个概念模型

减小阻碍国家公园管理目标实现的灾害风险，实现管理有效性，是保证国家公园体制建设建立的重要途径。研究提出，面向国家公园多元管理目标，保障社会-生态系统稳定性和恢复力，国家公园灾害风险管理具有综合性。这种综合性体现在国家公园内致灾因子与承灾体的多样性、相对性与转化性，需要集成分别侧重社会与生态系统的传统自然灾害风险管理与生态风险管理，让灾害风险管理贯穿国家公园具体管理。为实现集成应对这种综合性，研究首先总结国内外多类型自然保护地灾害风险管理特点与经验，辨析国家公园灾害风险管理在国家公园管理职责和管理规划中的定位，从3个方面提出对我国国家公园灾害风险管理的启示：1）需要与国家公园宏观管理目标紧密相连；2）以维持社会-生态系统理想状态为目标；3）要具有管理空间、时间与运行的整体性。在此基础上提出一个面向国家公园管理目标的综合灾害风险管理框架，其主要特点是：1）具有"层级式"管理目标；2）以社会-生态系统服务为评价终点开展以理想状态为目标的风险管理；3）联结研究与管理、协调科学与价值观进行适应性管理。     

MicroRNA‐148a‐3p suppresses epithelial‐to‐mesenchymal transition and stemness properties via Wnt1‐mediated Wnt/β‐catenin pathway in pancreatic cancer

Although miR‐148a‐3p has been reported to function as a tumour suppressor in various cancers, the molecular mechanism of miR‐148a‐3p in regulating epithelial‐to‐mesenchymal transition (EMT) and stemness properties of pancreatic cancer (PC) cells remains to be elucidated. In the present study, we demonstrated that miR‐148a‐3p expression was remarkably down‐regulated in PC tissues and cell lines. Moreover, low expression of miR‐148a‐3p was associated with poorer overall survival (OS) in patients with PC. In vitro, gain‐of‐function and loss‐of‐function experiments showed that miR‐148a‐3p suppressed EMT and stemness properties as well as the proliferation, migration and invasion of PC cells. A dual‐luciferase reporter assay demonstrated that Wnt1 was a direct target of miR‐148a‐3p, and its expression was inversely associated with miR‐148a‐3p in PC tissues. Furthermore, miR‐148a‐3p suppressed the Wnt/β‐catenin pathway via down‐regulation of Wnt1. The effects of ectopic miR‐148a‐3p were rescued by Wnt1 overexpression. These biological functions of miR‐148a‐3p in PC were also confirmed in a nude mouse xenograft model. Taken together, these findings suggest that miR‐148a‐3p suppresses PC cell proliferation, invasion, EMT and stemness properties via inhibiting Wnt1‐mediated Wnt/β‐catenin pathway and could be a potential prognostic biomarker as well as a therapeutic target in PC.