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51.
The reaction of adrenaline autooxidation in an alkaline carbonate buffer followed by formation of superoxide radicals and
the product of its oxidation, adrenochrome, which models the quinone pathway of adrenaline metabolism in the body, is accompanied
by oxygen consumption. A study of this process by the polarographic method enabled one to apply this reaction to determine
the activity of superoxide dismutase and antioxidant properties of biological and chemical compounds; it is based on evaluation
of a latent period and the rate of oxygen consumption, which are measured in the presence of examined compounds. It was suggested
that known neuroand cardiotoxicity of the quinone products of adrenaline oxidation may be associated not only to their intrinsic
properties and reactive oxygen species formed but also local hypoxia of those regions of the cell and tissue where the quinone
oxidation of adrenaline occurs. 相似文献
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55.
Sebastian Maurer-Stroh Jianmin Ma Raphael Tze Chuen Lee Fernanda L Sirota Frank Eisenhaber 《Biology direct》2009,4(1):18-9
In this work, we study the consequences of sequence variations of the "2009 H1N1" (swine or Mexican flu) influenza A virus strain neuraminidase for drug treatment and vaccination. We find that it is phylogenetically more closely related to European H1N1 swine flu and H5N1 avian flu rather than to the H1N1 counterparts in the Americas. Homology-based 3D structure modeling reveals that the novel mutations are preferentially located at the protein surface and do not interfere with the active site. The latter is the binding cavity for 3 currently used neuraminidase inhibitors: oseltamivir (Tamiflu®), zanamivir (Relenza®) and peramivir; thus, the drugs should remain effective for treatment. However, the antigenic regions of the neuraminidase relevant for vaccine development, serological typing and passive antibody treatment can differ from those of previous strains and already vary among patients.
Reviewers
This article was reviewed by Sandor Pongor and L. Aravind. 相似文献56.
57.
By comparative analysis of fingerprints of arbitrarily primed polymerase chain reaction (AP-PCR) products, DNA alterations in somatic cells of the progeny (F1 generation) of male mice chronically exposed to low-doses of gamma-radiation was investigated. Male BALB/c mice exposed to 10-50 cGy were mated with unirradiated females 15 days after irradiation. DNA was isolated from biopsies taken from tail tips of 2-month-old progeny. Preliminary AP-PCRs were carried out with 17 primers representing core sequences of micro- and/or minisatellites or their flanking oligonucleotides. Best quantitatively reproduced AP-PCR fingerprints of genomic DNA were obtained with one of these primers, a 20-mer oligonucleotide flanking the micro-satellite locus Atplb2 on mouse chromosome 11. Comparative analysis of individual fingerprints of AP-PCR products obtained on DNA templates from the progeny of irradiated and intact males revealed an increased variability of micro-satellite-associated sequences and an increased frequency of "non-parental bands" in DNA-fingerprints from the progeny of males chronically exposed to gamma-radiation 15 days before mating (at the postmeiotic stage of spermatogenesis). The results show that increased micro-satellite instability can be initiated by irradiation of the male parent to subsequently arise or be transmitted to the soma of the F1 generations. 相似文献
58.
Zaichkina SI Rozanova OM Aptikaeva GF Akhmadieva AKh Smirnova EN Romanchenko SP Sirota NP Vachrusheva OA Peleshko VN 《Radiation and environmental biophysics》2007,46(2):131-135
In the present work, the effect of a low-dose rate of high-LET radiation in polychromatic erythrocytes of mice bone marrow
was investigated in vivo. The spectral and component composition of the radiation field used was similar to that present in
the atmosphere at an altitude of about 10 km. The dose dependence, adaptive response, and genetic instability in the F1 generation born from males irradiated under these conditions were examined using the micronucleus test. Irradiation of the
mice was performed for 24 h per day in the radiation field behind the concrete shield of the Serpukhov accelerator. Protons
of 70 GeV were used over a period of 15–31 days, to accumulate doses of 11.5–31.5 cGy. The experiment demonstrated that irradiation
of mice in vivo in this dose range leads to an increase in cytogenetic damage to bone marrow cells, but does not induce any
adaptive response. In mice pre-irradiated with a dose of 11.5 cGy, an increase in sensitivity was observed after an additional
irradiation with a dose of 1.5 Gy. The absence of an adaptive response suggests existence of genetic instability. 相似文献
59.
Sirota TV Eliseeva OP Khunderiakova NV Kaminskiĭ DV Makhotina OA Kondrashova MN 《Ukrainski? biokhimicheski? zhurnal》2007,79(5):196-203
It has been shown that a three-week feeding of rats with oil derived from seeds of amaranth (Amaranthus cruentus L.) leads to a moderate activation of respiration of coupled and uncoupled rat liver mitochondria (MCh) that oxidize succinate and succinate + glutamate, as well as alpha-ketoglutarate and alpha-ketoglutarate + malonate. In animals receiving the amaranth oil, the injection of adrenaline did not affect the oil-activated respiration of MCh during succinate oxidation; i. e., animals prepared by an oil-enriched diet were resistant to the action of adrenaline, which prevented from possible hyperactivation of mitochondrial functions. In the group of control animals, which received no oil, the injection of adrenaline activated the rate of phosphorylating respiration of MCh during oxidation of succinate or succinate + glutamate: the rate of oxygen uptake in state 3 respiration (by Chance) increased, and the phosphorylation time decreased. The injection of adrenaline did not affect the parameters of respiration of MCh that oxidize a-ketoglutarate; however, in the presence of malonate, the oxidation of alpha-ketoglutarate in state 3 and uncoupled respiration have shown mild but significant increase in response to adrenaline. In animals receiving the amaranth oil, the oil-induced activation of respiration of MCh in response to adrenaline retained but did not increase; however, the phosphorylation time significantly decreased. Thus, concentrated oil of seeds activates the respiration of MCh. In addition, it enhances an energetic function of MCh, which prevents from the hyper-activation of mitochondrial respiration by adrenaline. Therefore an activation of energetic function of MCh by amaranth oil could explain its adaptogenic effect on rats. 相似文献
60.
Biophysics - Abstract—Changes in the level of DNA damage induced by atmospheric factors were evaluated from the percentage of tail DNA (%TDNA) in the comet assay of mouse cells for blood... 相似文献