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121.
Maja Marasovic Sinisa Ivankovic Ranko Stojkovic Damir Djermic Borivoj Galic 《Journal of enzyme inhibition and medicinal chemistry》2017,32(1):1299-1304
The cytotoxic activity of phenylboroxine acid was evaluated in vitro on mouse mammary adenocarcinoma 4T1, mouse squamous cell carcinoma SCCVII, hamster lung fibroblast V79 and mouse dermal fibroblasts L929 cell lines. The cytotoxic effects were dose dependent for all tested tumour and non-tumour cell lines. Under in vivo conditions, three application routes of phenylboronic acid were studied: intra-peritoneal (i.p.), intra-tumour (i.t.) and per-oral. After tumour transplantation in syngeneic mice, phenylboronic acid was shown to slow the growth of both tumour cell lines (4T1 and SCCVII) compared with the control. The inhibitory effects were pronounced during the application of phenylboronic acid. For both tested tumour cell lines, the most prominent antitumour effect was obtained by intraperitoneal administration, followed significantly by oral administration. 相似文献
122.
A Levy P T Manoharan J M Rifkind J C Walker F C Haberle N G Kumar J D Glickson G A Elgavish 《Biochimica et biophysica acta》1989,991(1):97-108
Iron-57 M?ssbauer, electron paramagnetic resonance (EPR) and H-1 nuclear magnetic resonance (NMR) studies of iron-bleomycin complexes in the pH range from 1.0 to 6.0 are reported. Sequential protonation of the ligands produces a variety of high-spin and low-spin complexes of the metal. Of particular interest is the reversible equilibrium between Fe(III)- and oxygen-stable Fe(II)-bleomycin. Below pH 3.5 Fe(II) complexes form, with maximal reduction occurring at approximately pH 2. At still lower pH, Fe(III) complexes unassociated with bleomycin become dominant. The observed reduction in the absence of exogenous reducing agents suggests the possible involvement of intramolecular autoreduction in bleomycin-mediated DNA degradation. 相似文献
123.
Heath Martin J. Doyle Laurance R. Joshi Manoj M. Haberle Robert M. 《Origins of life and evolution of the biosphere》1999,29(4):405-424
Recent models indicate that relatively moderate climates could exist on Earth-sized planets in synchronous rotation around red dwarf stars. Investigation of the global water cycle, availability of photosynthetically active radiation in red dwarf sunlight, and the biological implications of stellar flares, which can be frequent for red dwarfs, suggests that higher plant habitability of red dwarf planets may be possible. 相似文献
124.
A conceptual framework for predicting temperate ecosystem sensitivity to human impacts on fire regimes 总被引:2,自引:0,他引:2
125.