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991.
A new species of oak gallwasp, Latuspina manmiaoyangae sp. nov., is described in Taiwan. The species induces leaf galls on Quercus variabilis (Fagaceae). Data on the diagnosis, distribution, and biology of the new species are given. This is the second known Latuspina species. 相似文献
992.
Kim Y Sinclair R Chindapol N Kaandorp JA De Schutter E 《PLoS computational biology》2012,8(4):e1002474
The complex three-dimensional shapes of tree-like structures in biology are constrained by optimization principles, but the actual costs being minimized can be difficult to discern. We show that despite quite variable morphologies and functions, bifurcations in the scleractinian coral Madracis and in many different mammalian neuron types tend to be planar. We prove that in fact bifurcations embedded in a spatial tree that minimizes wiring cost should lie on planes. This biologically motivated generalization of the classical mathematical theory of Euclidean Steiner trees is compatible with many different assumptions about the type of cost function. Since the geometric proof does not require any correlation between consecutive planes, we predict that, in an environment without directional biases, consecutive planes would be oriented independently of each other. We confirm this is true for many branching corals and neuron types. We conclude that planar bifurcations are characteristic of wiring cost optimization in any type of biological spatial tree structure. 相似文献
993.
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function 总被引:1,自引:0,他引:1
Price NL Gomes AP Ling AJ Duarte FV Martin-Montalvo A North BJ Agarwal B Ye L Ramadori G Teodoro JS Hubbard BP Varela AT Davis JG Varamini B Hafner A Moaddel R Rolo AP Coppari R Palmeira CM de Cabo R Baur JA Sinclair DA 《Cell metabolism》2012,15(5):675-690
Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germline SIRT1 knockouts, we have developed an inducible system that permits whole-body deletion of SIRT1 in adult mice. Mice treated with a moderate dose of resveratrol showed increased mitochondrial biogenesis and function, AMPK activation, and increased NAD(+) levels in skeletal muscle, whereas SIRT1 knockouts displayed none of these benefits. A mouse overexpressing SIRT1 mimicked these effects. A high dose of resveratrol activated AMPK in a SIRT1-independent manner, demonstrating that resveratrol dosage is a critical factor. Importantly, at both doses of resveratrol no improvements in mitochondrial function were observed in animals lacking SIRT1. Together these data indicate that SIRT1 plays an essential role in the ability of moderate doses of resveratrol to stimulate AMPK and improve mitochondrial function both in vitro and in vivo. 相似文献
994.
The zinc homeostasis network of land plants 总被引:3,自引:0,他引:3
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W. J. Sinclair 《BMJ (Clinical research ed.)》1904,1(2256):713-715
998.
W. J. Sinclair 《BMJ (Clinical research ed.)》1902,1(2162):1450-1452
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