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241.
Arrigoni Roberto Maggioni Davide Montano Simone Hoeksema Bert W. Seveso Davide Shlesinger Tom Terraneo Tullia Isotta Tietbohl Matthew D. Berumen Michael L. 《Coral reefs (Online)》2018,37(4):967-984
Coral Reefs - Fire corals of the hydrocoral genus Millepora provide an important ecological role as framework builders of coral reefs in the Indo-Pacific and the Atlantic. Recent works have... 相似文献
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Fang Wang Simone Orioli Alan Ianeselli Giovanni Spagnolli Silvio a Beccara Anne Gershenson Pietro Faccioli Patrick L. Wintrode 《Biophysical journal》2018,114(9):2083-2094
Protein misfolding is implicated in many diseases, including serpinopathies. For the canonical inhibitory serpin α1-antitrypsin, mutations can result in protein deficiencies leading to lung disease, and misfolded mutants can accumulate in hepatocytes, leading to liver disease. Using all-atom simulations based on the recently developed bias functional algorithm, we elucidate how wild-type α1-antitrypsin folds and how the disease-associated S (Glu264Val) and Z (Glu342Lys) mutations lead to misfolding. The deleterious Z mutation disrupts folding at an early stage, whereas the relatively benign S mutant shows late-stage minor misfolding. A number of suppressor mutations ameliorate the effects of the Z mutation, and simulations on these mutants help to elucidate the relative roles of steric clashes and electrostatic interactions in Z misfolding. These results demonstrate a striking correlation between atomistic events and disease severity and shine light on the mechanisms driving chains away from their correct folding routes. 相似文献
244.
Vacuolated PAS‐positive lymphocytes as an hallmark of Pompe disease and other myopathies related to impaired autophagy 下载免费PDF全文
Angelo Pascarella Chiara Terracciano Olimpia Farina Luca Lombardi Teresa Esposito Filomena Napolitano Giuseppina Franzese Giovanni Panella Francesco Tuccillo Giancarlo la Marca Sergio Bernardini Silvia Boffo Antonio Giordano Giuseppe Di Iorio Mariarosa A.B. Melone Simone Sampaolo 《Journal of cellular physiology》2018,233(8):5829-5837
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Mesenchymal stromal cells prevent bleomycin‐induced lung and skin fibrosis in aged mice and restore wound healing 下载免费PDF全文
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Jennifer Hüpeden Simone Wegen Sandra Off Sebastian Lücker Yvonne Bedarf Holger Daims Carsten Kühn Eva Spieck 《Applied and environmental microbiology》2016,82(6):1838-1845
The functioning of recirculation aquaculture systems (RAS) is essential to maintain water quality for fish health, and one crucial process here is nitrification. The investigated RAS was connected to a rainbow trout production system and operated at an average temperature of 13°C and pH 6.8. Community analyses of the nitrifying biofilm revealed a coexistence of Nitrospira and Nitrotoga, and it is hypothesized that a slightly acidic pH in combination with lower temperatures favors the growth of the latter. Modification of the standard cultivation approach toward lower pH values of 5.7 to 6.0 resulted in the successful enrichment (99% purity) of Nitrotoga sp. strain HW29, which had a 16S rRNA sequence similarity of 99.0% to Nitrotoga arctica. Reference cultures of Nitrospira defluvii and the novel Nitrotoga sp. HW29 were used to confirm differentiation of these nitrite oxidizers in distinct ecological niches. Nitrotoga sp. HW29 revealed pH and temperature optima of 6.8 and 22°C, respectively, whereas Nitrospira defluvii displayed the highest nitrite oxidation rate at pH 7.3 and 32°C. We report here the occurrence of Nitrotoga as one of the main nitrite-oxidizing bacteria in freshwater aquaculture systems and indicate that a slightly acidic pH, in addition to temperatures below 20°C, can be applied as a selective isolation criterion for this microorganism. 相似文献
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Darren R. Brenner Paul Brennan Paolo Boffetta Christopher I. Amos Margaret R. Spitz Chu Chen Gary Goodman Joachim Heinrich Heike Bickeböller Albert Rosenberger Angela Risch Thomas Muley John R. McLaughlin Simone Benhamou Christine Bouchardy Juan Pablo Lewinger John S. Witte Gary Chen Shelley Bull Rayjean J. Hung 《Human genetics》2016,135(8):963-963
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