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281.
282.
Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.
283.
Caroline Sauer Sebastian Klobuch Wolfgang Herr Simone Thomas Bodo Plachter 《Journal of virology》2013,87(20):11287-11291
Dendritic cells play a central role in the immune control of human cytomegalovirus (HCMV) infection. This work aimed at investigating the impact of noninfectious, subviral dense bodies of HCMV on the maturation and activation of dendritic cells (DC). Treatment of immature DC with dense bodies led to the maturation of these cells and significantly increased their capacity for cytokine release and antigen presentation. Dense body-activated DC may thereby contribute to the development of antiviral immunity. 相似文献
284.
Magdalena Witek Luca Pietro Casacci Francesca Barbero Dario Patricelli Marco Sala Simone Bossi Massimo Maffei Michal Woyciechowski Emilio Balletto Simona Bonelli 《Biological journal of the Linnean Society. Linnean Society of London》2013,109(3):699-709
Myrmica ant colonies host numerous insect species, including the larvae of Maculinea butterflies and Microdon myrmicae hoverflies. Little is known about the interspecific relationships among these social parasites and their host ants occurring in sympatric populations. We investigated communities of social parasites to assess the strategies allowing them to share the same pool of resources (i.e. Myrmica colonies). The present study was carried out at five sites inhabited by different social parasite communities, each comprising varying proportions of Maculinea teleius, Maculinea nausithous, Maculinea alcon, and Microdon myrmicae. We investigated their spatial distributions, host segregation, the degree of chemical similarity between social parasites and hosts, and temporal overlaps in colony resource exploitation. Spatial segregation among social parasites was found in two populations and it arises from microhabitat preferences and biological interactions. Local conditions can drive selection on one social parasite to use a Myrmica host species that is not exploited by other social parasites. Myrmica scabrinodis and Myrmica rubra nests infested by larvae of two social parasite species were found and the most common co‐occurrence was between Ma. teleius and Mi. myrmicae. The successful coexistence of these two species derives from their exploitation of the host colony resources at different times of the year. © 2013 The Linnean Society of London, Biological Journal of the Linnean Society, 2013, 109 , 699–709. 相似文献
285.
Peter J. Humphries Simone Linz Charles Semple 《Bulletin of mathematical biology》2013,75(10):1879-1890
Recently, we have shown that calculating the minimum–temporal-hybridization number for a set ${\mathcal{P}}$ of rooted binary phylogenetic trees is NP-hard and have characterized this minimum number when ${\mathcal{P}}$ consists of exactly two trees. In this paper, we give the first characterization of the problem for ${\mathcal{P}}$ being arbitrarily large. The characterization is in terms of cherries and the existence of a particular type of sequence. Furthermore, in an online appendix to the paper, we show that this new characterization can be used to show that computing the minimum–temporal hybridization number for two trees is fixed-parameter tractable. 相似文献
286.
Teresa Braunwald Lisa Schwemmlein Simone Graeff-Hönninger William Todd French Rafael Hernandez William E. Holmes Wilhelm Claupein 《Applied microbiology and biotechnology》2013,97(14):6581-6588
Due to the increasing demand for sustainable biofuels, microbial oils as feedstock for the transesterification into biodiesel have gained scientific and commercial interest. Also, microbial carotenoids have a considerable market potential as natural colorants. The carbon to nitrogen (C/N) ratio of the respective cultivation media is one of the most important parameters that influence the production of microbial lipids and carotenoids. Thus, in the present experiment, the influence of different C/N ratios, initial glucose loadings, and ammonium concentrations of the cultivation medium on microbial cell growth and lipid and carotenoid production by the oleaginous red yeast Rhodotorula glutinis has been assessed. As a general trend, both lipid and carotenoid production increased at high C/N ratios. It was shown that not only the final C/N ratio but also the respectively applied initial carbon and nitrogen contents influenced the observed parameters. The lipid yield was not affected by different ammonium contents, while the carotenoid production significantly decreased both at low and high levels of ammonium supply. A glucose-based increase from C/N 70 to 120 did not lead to an increased lipid production, while carotenoid synthesis was positively affected. Generally, it can be asserted that lipid and carotenoid synthesis are stimulated at higher C/N ratios. 相似文献
287.
Alessandra Podda Giovanni Checcucci Wafa Mouhaya Delphine Centeno Valerie Rofidal Renata Del Carratore François Luro Raphael Morillon Patrick Ollitrault Bianca Elena Maserti 《Journal of plant physiology》2013
To understand the genotypic variation of citrus to mild salt stress, a proteomic approach has been carried out in parallel on two citrus genotypes (‘Cleopatra’ and ‘Willow leaf’ mandarins), which differ for Na+ and Cl− accumulation, and their cognate autotetraploids (4×). Using two-dimensional electrophoresis approximately 910 protein spots were reproducibly detected in control and salt-stressed leaves of all genotypes. Among them, 44 protein spots showing significant variations at least in one genotype were subjected to mass spectrometry analysis for identification. Salt-responsive proteins were involved in several functions, including photosynthetic processes, ROS scavenging, stress defence, and signalling. Genotype factors affect the salt-responsive pattern, especially that of carbon metabolism. The no ion accumulator ‘Cleopatra’ mandarin genotype showed the highest number of salt-responsive proteins, and up-regulation of Calvin cycle-related proteins. Conversely the ion accumulator ‘Willow leaf’ mandarin showed high levels of several photorespiration-related enzymes. A common set of proteins (twelve spots) displayed higher levels in salt-stressed leaves of 2× and 4× ‘Cleopatra’ and 4× ‘Willow leaf’ mandarin. Interestingly, antioxidant enzymes and heat shock proteins showed higher constitutive levels in 4× ‘Cleopatra’ mandarin and 4× ‘Willow leaf’ mandarin compared with the cognate 2× genotype. This work provides for the first time information on the effect of 8 weeks of salt stress on citrus genotypes contrasting for ion accumulation and their cognate autotetraploids. Results underline that genetic factors have a predominant effect on the salt response, although a common stress response independent from genotype was also found. 相似文献
288.
Roger Fuoco Patrizia Bogani Gabriele Capodaglio Massimo Del Bubba Ornella Abollino Stefania Giannarelli Maria Michela Spiriti Beatrice Muscatello Saer Doumett Clara Turetta Roberta Zangrando Vincenzo Zelano Marcello Buiatti 《Journal of plant physiology》2013
Recently our findings have shown that the integration of the gene coding for the rat gluco-corticoid receptor (GR receptor) in Nicotiana langsdorffii plants induced morphophysiological effects in transgenic plants through the modification of their hormonal pattern. Phytohormones play a key role in plant responses to many different biotic and abiotic stresses since a modified hormonal profile up-regulates the activation of secondary metabolites involved in the response to stress. In this work transgenic GR plants and isogenic wild type genotypes were exposed to metal stress by treating them with 30 ppm cadmium(II) or 50 ppm chromium(VI). Hormonal patterns along with changes in key response related metabolites were then monitored and compared. Heavy metal up-take was found to be lower in the GR plants. The transgenic plants exhibited higher values of S-abscisic acid (S-ABA) and 3-indole acetic acid (IAA), salicylic acid and total polyphenols, chlorogenic acid and antiradical activity, compared to the untransformed wild type plants. Both Cd and Cr treatments led to an increase in hormone concentrations and secondary metabolites only in wild type plants. Analysis of the results suggests that the stress responses due to changes in the plant's hormonal system may derive from the interaction between the GR receptor and phytosteroids, which are known to play a key role in plant physiology and development. 相似文献
289.
Capsule A newly created wetland has been beneficial for the breeding of five heron species and for the settlement and expansion of Glossy Ibises in the region. Aim To determine whether created wetland would lead to the establishment of a heron and ibis breeding colony, and if so, to determine its effects on the distribution of these species in the wider region. Methods Number of pairs breeding at the new wetland and in the region were estimated annually from 1996 to 2008. We investigated whether the growth of the new colony was explained by redistribution of breeding pairs within the region. Results Purple Herons, Squacco Herons and Glossy Ibises colonised the new wetland in 1996. Black‐crowned Night Herons settled in 1998, while Cattle and Little Egrets were the last species to establish in the mixed colony in 2001. The population increase was particularly marked for Glossy Ibises (which had bred in Doñana only sporadically through the 20th century). Our findings suggest that simple redistribution of pairs does not explain the formation and growth of the new colony. Since the first year of establishment numbers of Glossy Ibises and Purple Herons have shown a significant growth trend at both the new colony and in Doñana. Conclusion The creation and management of a new wetland has been successful for the conservation of heron and egret species and promoted the expansion of the Glossy Ibis population across the western Mediterranean region. 相似文献
290.
Josh Hough Simone Immler Spencer C. H. Barrett Sarah P. Otto 《Evolution; international journal of organic evolution》2013,67(7):1915-1925
Frequency‐dependent selection should drive dioecious populations toward a 1:1 sex ratio, but biased sex ratios are widespread, especially among plants with sex chromosomes. Here, we develop population genetic models to investigate the relationships between evolutionarily stable sex ratios, haploid selection, and deleterious mutation load. We confirm that when haploid selection acts only on the relative fitness of X‐ and Y‐bearing pollen and the sex ratio is controlled by the maternal genotype, seed sex ratios evolve toward 1:1. When we also consider haploid selection acting on deleterious mutations, however, we find that biased sex ratios can be stably maintained, reflecting a balance between the advantages of purging deleterious mutations via haploid selection, and the disadvantages of haploid selection on the sex ratio. Our results provide a plausible evolutionary explanation for biased sex ratios in dioecious plants, given the extensive gene expression that occurs across plant genomes at the haploid stage. 相似文献