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P Carde C Chastang E Goncalves N Mathieu-Tubiana E Vuillemin V Delwail O Corbion A Vekhoff F Isnard J M Ferrero 《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1992,315(13):545-550
Seraspenide, a synthetic tetrapeptide, inhibits cell cycle entry of normal hematopoietic stem cells. In mice it protects hemopoiesis against the damage caused by cytarabine, cyclophosphamide and carboplatin. Seraspenide has been given to 53 cancer patients undergoing monochemotherapy with cytarabine and ifosfamide in a double-blind cross-over randomized study. A significant protection of peripheral blood cells has been observed. Seraspenide has been devoided of toxicity. 相似文献
214.
Rapid Migration of Inositol Phospholipids with Axonally Transported Substances in the Rabbit Optic Pathway 总被引:3,自引:3,他引:0
Following an intraocular injection of myo-[2-3H]inositol, the axonal transport of labelled water-soluble substances and inositol phospholipids was investigated. Evidence was obtained for a rapid axonal transport of a relatively small amount of labelled inositol phospholipids. In contrast to other axonally transported phospholipids, there was no significant accumulation of labelled, rapidly transported inositol phospholipids in the nerve terminal region at later time intervals following the isotope administration. 相似文献
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Ildikó Vidra Kálmán Simon László Institóris Ingeborg Csöregh Mátyás Czugler 《Carbohydrate research》1982,111(1):41-57
After hydrolysis of 1,6-dibromo-1,6-dideoxygalactitol (1) and 1,2:5,6-dianhydrogalactitol (2), 11 compounds were isolated, three of them as tritylated derivatives. Their structures were established on the basis of chemical evidence and, for four compounds, by X-ray diffraction. The main product of the hydrolysis of 1 was 3,6-anhydro-1-bromo-1-deoxy-dl-galactitol; the end-products of the hydrolysis of 2 were 1,5-anhydro-dl-galactitol, 2,5-anhydro-dl-altritol, and galactitol. 相似文献
220.
Summary Two siblings with a short-limb dwarfing condition which we call acromesomelic dysplasia, Hunter-Thompson type are reported. Abnormalities are limited to the limbs and limb joints in this severe form of dwarfism. The middle and distal
segments of the limbs are most affected. The lower limbs are more affected than the upper. We are aware of one previously
published case of this entity reported by A. G. W. Hunter and M. W. Thompson in 1976. Dislocations of the elbows and ankles
were present in all three patients and dislocations of the hips and knees in two. One of the siblings who did not have hip
and knee dislocations clinically resembled Grebe chondrodysplasia, another severe acromesomelic dwarfing condition. However,
radiological analysis suggests that while acromesomelic dysplasia, Hunter-Thompson type and Grebe chondrodysplasia are related,
they are not identical. Grebe chondrodysplasia has been established as an autosomal recessive trait. It appears probable that
the entity we describe has the same mode of genetic transmission. 相似文献