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EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis 总被引:1,自引:0,他引:1
EVI5 has been shown to be a novel centrosomal protein in interphase cells. In this report, we demonstrate using immunofluorescence microscopy that EVI5 has a dynamic distribution during mitosis, being associated with the mitotic spindle through anaphase and remaining within the midzone and midbody until completion of cytokinesis. Knockdown of EVI5 using siRNA results in a multinucleate phenotype, which is consistent with an essential role for this protein in the completion of cytokinesis. The EVI5 protein also undergoes posttranslational modifications during the cell cycle, which involve phosphorylation in early mitosis and proteolytic cleavage during late mitosis and cytokinesis. Since the subcellular distribution of the EVI5 protein was similar to that characteristic of chromosomal passenger proteins during the terminal stages of cytokinesis, we used immunoprecipitation and GST pull-down approaches to demonstrate that EVI5 is associated with the aurora B kinase protein complex (INCENP, aurora B kinase and survivin). Together, these data provide evidence that EVI5 is an essential component of the protein machinery facilitating the final stages of cell septation at the end of mitosis. 相似文献
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Anna V. Koromyslova Silviu O. Martha Alexey V. Pakhnevich 《Annales de Paléontologie》2019,105(1):1-19
Porina-like cheilostome bryozoans are a taxonomically problematic group. They were moderately common in latest Cretaceous sediments throughout the world. However, the complexity of their tiny skeletons makes it difficult to describe species morphologically, especially as many features have no counterparts in Recent cheilostomes. In this contribution, we revise the type material of most known Porina-like cheilostomes from the Campanian and Maastrichtian of Central Asia using combined scanning electron microscopy and X-ray microtomography. The revised species are Diplobeisselina? abduazimovae (Favorskaya, 1992), Beisselinopsis quincunx Voigt, 1962, Pseudobathystomella lata Favorskaya, 1988, Beisselina bella Favorskaya, 1980 and Uzbekipora anplievae (Favorskaya, 1992). Pseudobathystomella mira sp. nov. is proposed for one colony previously identified as Pseudobathystomella lata, while one badly preserved specimen previously assigned to Beisselina bella is described here in open nomenclature as Beisselina? sp. The diagnosis of Pseudobathystomella Favorskaya, 1988 is amended. Uzbekipora gen. nov. is introduced for one species from the southern Aral Sea region in Uzbekistan showing a frontal shield traversed by a reticulate network of ridges that conceals autozooidal boundaries and encloses foraminate mounds. 相似文献
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In 1922, the first taxonomic work on Maastrichtian bryozoans from Madagascar was published in the Annales de Paléontologie by Ferdinand Canu. Canu described 25 species, 17 of which were regarded as new but the material has never been revised until now. Here we employ scanning electron microscopy (SEM) to illustrate Canu's material and revise the taxonomy. Based on this revision, 23 species, comprising eight cyclostomes and 15 cheilostomes, are recognized. A new genus, Fehiborypora, is introduced for the cribrimorph Cribilina (?) labiatula, and two new species are described: ‘Plagioecia’ antanihodiensis sp. nov. and ‘Escharoides’ charbonnieri sp. nov. Galeopsis parvipora is synonymized with Crustoporina prona Stoliczka. All bryozoan species found are encrusters on echinoids or oysters. 相似文献
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Silviu O. Petrovan David C. Aldridge Harriet Bartlett Andrew J. Bladon Hollie Booth Steven Broad Donald M. Broom Neil D. Burgess Sarah Cleaveland Andrew A. Cunningham Maurizio Ferri Amy Hinsley Fangyuan Hua Alice C. Hughes Kate Jones Moira Kelly George Mayes Milorad Radakovic Chinedu A. Ugwu Nasir Uddin Diogo Veríssimo Christian Walzer Thomas B. White James L. Wood William J. Sutherland 《Biological reviews of the Cambridge Philosophical Society》2021,96(6):2694-2715
The crisis generated by the emergence and pandemic spread of COVID-19 has thrown into the global spotlight the dangers associated with novel diseases, as well as the key role of animals, especially wild animals, as potential sources of pathogens to humans. There is a widespread demand for a new relationship with wild and domestic animals, including suggested bans on hunting, wildlife trade, wet markets or consumption of wild animals. However, such policies risk ignoring essential elements of the problem as well as alienating and increasing hardship for local communities across the world, and might be unachievable at scale. There is thus a need for a more complex package of policy and practical responses. We undertook a solution scan to identify and collate 161 possible options for reducing the risks of further epidemic disease transmission from animals to humans, including potential further SARS-CoV-2 transmission (original or variants). We include all categories of animals in our responses (i.e. wildlife, captive, unmanaged/feral and domestic livestock and pets) and focus on pathogens (especially viruses) that, once transmitted from animals to humans, could acquire epidemic potential through high rates of human-to-human transmission. This excludes measures to prevent well-known zoonotic diseases, such as rabies, that cannot readily transmit between humans. We focused solutions on societal measures, excluding the development of vaccines and other preventive therapeutic medicine and veterinary medicine options that are discussed elsewhere. We derived our solutions through reading the scientific literature, NGO position papers, and industry guidelines, collating our own experiences, and consulting experts in different fields. Herein, we review the major zoonotic transmission pathways and present an extensive list of options. The potential solutions are organised according to the key stages of the trade chain and encompass solutions that can be applied at the local, regional and international scales. This is a set of options targeted at practitioners and policy makers to encourage careful examination of possible courses of action, validating their impact and documenting outcomes. 相似文献
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