排序方式: 共有36条查询结果,搜索用时 15 毫秒
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Ludmila Yurchenko Vladimir Silnikov Tatyana Godovikova Gennady Shishlan Jean-Jacques Toulme Valentin Vlassov 《Nucleosides, nucleotides & nucleic acids》2013,32(7-9):1721-1725
Abstract RNA sequences derived from the Leishmania amazonensis mini-exon and pre-mini-exon sequences have been targeted with complementary oligonucleotides bearing a diimidazole construction mimicking active center of ribonuclease A. The conjugates were shown to cleave the target RNAs at specific positions. 相似文献
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S.V. Stovbun A.S. Vedenkin A.A. Bukhvostov L.S. Koroleva V.N. Silnikov D.A. Kuznetsov 《Biochemistry and Biophysics Reports》2020
The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher inhibitory activity than the synthesized and isolated D enantiomers of polynucleotides. The work also proposes a biophysical model that describes this effect. 相似文献
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Yu. V. Sherstyuk A. L. Zakharenko M. M. Kutuzov M. V. Sukhanova O. I. Lavrik V. N. Silnikov T. V. Abramova 《Russian Journal of Bioorganic Chemistry》2017,43(1):76-83
A convenient approach has been proposed to the synthesis of nicotinamide adenine dinucleotide (NAD+) mimetics, which comprise morpholino analogues of nucleosides. The approach is based on the use of ADP conjugates containing an amino group, which is tethered to the terminal phosphate through the aliphatic linker by the phosphodiester bond. We have synthesized four series of the NAD+ mimetics, which differ in the type of the modified nucleoside (2-aminomethylmorpholine (Mor) or 2-aminomethyl-4-carboxymethylmorpholine (MorGly) derivatives), in the linker length, and in the manner of the nucleoside attachment to the ADP derivative. We have studied the efficiency of NAD+ mimetics in the inhibition of the auto-poly(ADP-ribosyl)ation by the PARP 1 enzyme. The linker length, the mode of the attachment of the morpholino nucleoside analogue, and the nature of the heterocyclic base of the modified nucleoside were shown to inf luence the inhibition efficiency. 相似文献
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N. S. Zhdan I. L. Kuznetsova M. A. Zenkova A. V. Vlassov V. N. Silnikov R. Giege 《Nucleosides, nucleotides & nucleic acids》2013,32(6-7):1491-1492
Abstract RNA cleaving molecules were synthesized by conjugating components of ribonucleases A and T1 catalytic centers (imidazole, aliphatic amino and/or carboxy residues) to intercalating and cationic structures. The artificial ribonucleases were shown cleave RNA at Py-Pu sites in single-stranded regions. 相似文献