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排序方式: 共有257条查询结果,搜索用时 62 毫秒
241.
The reasons that cause delay in wound healing in diabetes are a decrease in the level of growth factors secretion, an increase in the destruction of growth factors and in oxidative stress. Platelet derived growth factor (PDGF) is one of the important growth factors that play a role in all phases of wound healing. This study investigates time-dependent effects of topically PDGF-BB administration on oxidative events on the healing of dorsolateral-excisional wounds in diabetic rats. Forty-two female Wistar-albino rats with streptozotocin-induced diabetes were divided into four groups: control group, untreated group, chitosan-treated group, chitosan?+?PDGF-BB-treated group. Two identical full-thickness excisional skin wounds were made under anaesthesia in all rats except for the control group. In the PDGF-BB-treated and chitosan-treated groups, the wounds were treated topically PDGF-BB (7?ng/mL, single daily dose) and blank chitosan gel (equal amount) after wounding, respectively. After these administrations, on day 3 and day 7 of wound healing, rats were sacrificed. Thiobarbituric acid reactive substances, glutathione, nitric oxide, ascorbic acid levels, and superoxide dismutase activity in wound tissues were spectrophotometrically measured. PDGF-BB administration significantly increased TBARS levels and non-enzymatic antioxidant levels in early phase of diabetic wound healing. PDGF-BB dramatically reduced NOx levels on day 3 and sharply increased NOx levels on day 7 of wound healing. Consequently, PDGF-BB administration can be effective on oxidative balance in the early phase of diabetic wound healing. 相似文献
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243.
Sargin CF Berker-Karaüzüm S Manguoğlu E Erdoğru T Karaveli S Gülkesen KH Baykara M Lüleci G 《Annales de génétique》2004,47(1):61-68
Intervals V and VI of Yq11.23 regions contain responsible genes for spermatogenesis, and are named as "azoospermia factor locus" (AZF). Deletions in these genes are thought to be pathogenetically involved in some cases of male infertility associated with azoospermia or oligozoospermia. The aim of this study was to establish the prevalence of microdeletions on the Y chromosome in infertile Turkish males with azoospermia or oligozoospermia. We applied multiplex polymerase chain reaction (PCR) using several sequence-tagged site (STS) primer sets, in order to determine Y chromosome microdeletions. In this study, 61 infertile males were enrolled for the molecular AZF screening program. In this cohort, one infertile male had 46,XX karyotype and the remaining had 46,XY karyotypes. Forty-eight patients had a diagnosis of azoospermia and 13 had oligozoospermia. Microdeletions in AZFa, AZFb and AZFc (DAZ gene) regions were detected in two of the 60 (3.3%) idiopathic infertile males with normal karyotypes and a SRY translocation was determined on 46,XX male. Our findings suggest that genetic screening should be advised to infertile men before starting assisted reproductive treatments. 相似文献
244.
ABSTRACT: The differences between invasive lobular and ductal carcinomas affect the diagnostic and therapeutic management for patients with breast cancer. In most cases, this can be accomplished because of distinct histomorphologic features. However, occasionally, this task may become quite difficult, in particular when dealing with the variants of infiltrating lobular carcinoma. Lobular carcinoma has been considered a variant of mucin-secreting carcinoma with only intracytoplasmic mucin. The presence of extracellular mucin is a feature of ductal carcinoma. Herein is presented a case of lobular carcinoma with extracellular and intracellular mucin in a 43-year-old female patient, and confirmed by immunohistochemistry. Up to the present, infiltrating lobular carcinoma displaying extracellular mucin has not been described in the literature except two case. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1839906067716744. 相似文献
245.
Sakacin B, a bacteriocin produced by Lactobacillus sake isolated from Greek dry fermented sausages 总被引:1,自引:1,他引:0
When Lactobacillus sake 251, a strain isolated from naturally fermented Greek dry sausage was grown in MRS broth it excreted an antimicrobial factor that differed from organic acids and hydrogen peroxide. The substance was proteinaceous, heat stable and inhibitory towards various lactic acid bacteria of meat origin. This suggested that a narrow spectrum bacteriocin, designated sakacin B, was present in the broth. Sakacin B displayed a bactericidal mode of action on sensitive cells without causing cell lysis. It was secreted during late logarithmic phase and was stable within a pH range 2 to 9. In vitro production of sakacin B by the producer strain in a mixed culture caused a strong biocidal effect on growing indicator cells. Sakacin B was partially purified and found not to contain unusual amino acids. That it was a hydrophobic peptide was confirmed by SDS-PAGE electrophoresis. The molecular weight of sakacin B was estimated to be 6.3 kDa. 相似文献
246.
Sayid Shafi Zuhur Hunkar Aggul Mehmet Çelik Ugur Avci Selvinaz Erol Faruk Kilinç Gulhan Akbaba Nese Cinar Sakin Tekin Serdar Sahin Ogun Bilen Gulsah Elbuken Sibel Guldiken Pinar Kadioglu Taner Bayraktaroglu Birol Topcu Yuksel Altuntas 《Endocrine practice》2022,28(1):30-35
ObjectiveAlthough the age at diagnosis has been suggested as a major determinant of disease-specific survival in the recent TNM staging system, it is not included in the recent American Thyroid Association (ATA) guidelines to estimate the risk of recurrence. Nevertheless, the effect of sex on differentiated thyroid carcinoma (DTC) recurrence is controversial. Therefore, this multicenter study was conducted to assess whether age at diagnosis and sex can improve the performance of the ATA 3-tiered risk stratification system in patients with DTC with at least 5 years of follow-up.MethodsIn this study, the computer-recorded data of the patients diagnosed with DTC between January 1985 and January 2016 were analyzed. Only patients with proven structural persistent/recurrent disease were selected for comparisons.ResultsThis study consisted of 1691 patients (female, 1367) with DTC. In Kaplan-Meier analysis, disease-free survival (DFS) was markedly longer in females only in the ATA low-risk category (P = .045). Nevertheless, a markedly longer DFS was observed in patients aged <45 years in the ATA low- and intermediate-risk categories (P = .004 and P = .009, respectively), whereas in patients aged <55 years, DFS was markedly longer only in the ATA low-risk category (P < .001). In the Cox proportional hazards model, ages of ≥45 and ≥55 years at diagnosis and the ATA risk stratification system were all independent predictors of persistent/recurrent disease.ConclusionApplying the age cutoff of 45 years in the ATA intermediate- and low-risk categories may identify patients at a higher risk of persistence/recurrence and may improve the performance of the ATA risk stratification system, whereas sex may improve the performance of only the ATA low-risk category. 相似文献
247.
Sibel ?zyazgan Yesim Unlucerci Selda Bekpinar Ahmet G?khan Akkan 《Experimental diabetes research》2000,1(2):145-153
Aim The effect of 8 weeks′ streptozotocin (STZ)-
induced diabetes and aminoguanidine (AMNG), the
inhibitor of advanced glycosylation reaction, treatment
on arteriolar reactivity to vasoactive substances
was investigated in vitro.
Materials and Methods Studies were performed in
untreated control rats (n = 10), STZ-induced (60 mg/kg
i.v.) diabetic rats (n = 10), AMNG-treated (600 mg/l
given in drinking water throughout 8 weeks) control
rats (n = 10) and AMNG-treated (600 mg/l given in
drinking water, beginning at 72h after STZ and
throughout 8 weeks of diabetes) diabetic rats (n = 10).
Results are expressed as the mean ±s.e. Relaxant
responses are expressed as a percentage (%) relaxation
of noradrenaline-induced tone. Statistical comparisons
were made by one-way analysis of variance
(ANOVA) followed by Tukey–Kramer multiple
comparisons test.
Results 1. The decreased body weights (205 ± 6 g)
and increased blood glucose levels (583 ± 8 mg/dl) of
diabetic rats were partially restored by treatment of
aminoguanidine (253 ± 6 g, p < 0.05 and 480 ± 14 mg/dl, p < 0.001, respectively). 2. Diabetes caused a 71%
deficit in maximal endothelium-dependent relaxation
to acetylcholine for noradrenaline precontracted
aortas (p < 0.001). AMNG treatment prevented the
diabetes-induced impairment in endothelium dependent
relaxation (58 ± 8%) to acetylcholine, maximum
relaxation remaining in the non-diabetic range
(78 ± 4%). 3. Neither diabetes nor treatment affected endothelium-independent relaxation (pD2 and max.
Relax.) to sodium nitroprusside. 4. Vasoconstrictor
responses (pD2 and Max. Contraction) to noradrenaline
and KCl were not influenced by the diabetic
state and treatment.
Conclusion Our data suggest that 8 weeks of
experimental diabetes is associated with a decreased
endothelium-dependent vasodilatation. AMNG
treatment may prevent diabetes-induced endothelial
dysfunction. This may be mediated via the prevention
of advanced glycosylation end product formation,
the enhanced release of vasodilator substances
such as prostacyclin, the increased elasticity of blood
vessels, the antioxidant activity and inhibitor activity
of enzyme aldose-reductase by AMNG. 相似文献
248.
Sibel Özbudun Demirer 《Dialectical Anthropology》2011,35(1):111-129
Although the presence of anthropology is strongly felt during the first decades of the Turkish republican history, namely
the period between 1923 and 1940, it is striking to see that the discipline was conceived more as a nation-building device
than a scientific endeavour. This article traces the formation of Turkish anthropology from the late Ottoman period to the
consolidation of the Republican regime, emphasizing the interesting oscillations between physical and social/cultural anthropologies,
which are alternately brought to fore according to the requirements the political agenda. 相似文献
249.
250.