排序方式: 共有90条查询结果,搜索用时 15 毫秒
71.
Victoria E. Cotero Simon Y. Kimm Tiberiu M. Siclovan Rong Zhang Evgenia M. Kim Kazuhiro Matsumoto Tatsuo Gondo Peter T. Scardino Siavash Yazdanfar Vincent P. Laudone Cristina A. Tan Hehir 《PloS one》2015,10(6)
The ability to visualize and spare nerves during surgery is critical for avoiding chronic morbidity, pain, and loss of function. Visualization of such critical anatomic structures is even more challenging during minimal access procedures because the small incisions limit visibility. In this study, we focus on improving imaging of nerves through the use of a new small molecule fluorophore, GE3126, used in conjunction with our dual-mode (color and fluorescence) laparoscopic imaging instrument. GE3126 has higher aqueous solubility, improved pharmacokinetics, and reduced non-specific adipose tissue fluorescence compared to previous myelin-binding fluorophores. Dosing and kinetics were initially optimized in mice. A non-clinical modified Irwin study in rats, performed to assess the potential of GE3126 to induce nervous system injuries, showed the absence of major adverse reactions. Real-time intraoperative imaging was performed in a porcine model. Compared to white light imaging, nerve visibility was enhanced under fluorescence guidance, especially for small diameter nerves obscured by fascia, blood vessels, or adipose tissue. In the porcine model, nerve visualization was observed rapidly, within 5 to 10 minutes post-intravenous injection and the nerve fluorescence signal was maintained for up to 80 minutes. The use of GE3126, coupled with practical implementation of an imaging instrument may be an important step forward in preventing nerve damage in the operating room. 相似文献
72.
Elizabeth A. DAmbrosio Walter R. Drake Siavash Mashayekh Ophelia I. Ukaegbu Ashley R. Brown Catherine L. Grimes 《Bioorganic & medicinal chemistry letters》2019,29(10):1153-1161
The innate immune system is the body’s first defense against invading microorganisms, relying on the recognition of bacterial-derived small molecules by host protein receptors. This recognition event and downstream immune response rely heavily on the specific chemical features of both the innate immune receptors and their bacterial derived ligands. This review presents a chemist’s perspective on some of the most crucial and complex components of two receptors (NOD1 and NOD2): starting from the structural and chemical characteristics of bacterial-derived small molecules, to the specific proposed models of molecular recognition of these molecules by immune receptors, to the subsequent post-translational modifications that ultimately dictate downstream immune signaling. Recent advances in the field are discussed, as well as the potential for the development of targeted therapeutics. 相似文献
73.
Chao Zhang Celine Scornavacca Erin K Molloy Siavash Mirarab 《Molecular biology and evolution》2020,37(11):3292
Phylogenetic inference from genome-wide data (phylogenomics) has revolutionized the study of evolution because it enables accounting for discordance among evolutionary histories across the genome. To this end, summary methods have been developed to allow accurate and scalable inference of species trees from gene trees. However, most of these methods, including the widely used ASTRAL, can only handle single-copy gene trees and do not attempt to model gene duplication and gene loss. As a result, most phylogenomic studies have focused on single-copy genes and have discarded large parts of the data. Here, we first propose a measure of quartet similarity between single-copy and multicopy trees that accounts for orthology and paralogy. We then introduce a method called ASTRAL-Pro (ASTRAL for PaRalogs and Orthologs) to find the species tree that optimizes our quartet similarity measure using dynamic programing. By studying its performance on an extensive collection of simulated data sets and on real data sets, we show that ASTRAL-Pro is more accurate than alternative methods. 相似文献
74.
Kishore Jaganathan Sofia Kyriazopoulou Panagiotopoulou Jeremy F. McRae Siavash Fazel Darbandi David Knowles Yang I. Li Jack A. Kosmicki Juan Arbelaez Wenwu Cui Grace B. Schwartz Eric D. Chow Efstathios Kanterakis Hong Gao Amirali Kia Serafim Batzoglou Stephan J. Sanders Kyle Kai-How Farh 《Cell》2019,176(3):535-548.e24
75.
Rasouli-Sadaghiani M. H. Barin M. Khodaverdiloo H. Siavash Moghaddam S. Damalas C. A. Kazemalilou S. 《Journal of Plant Growth Regulation》2019,38(1):113-121
Journal of Plant Growth Regulation - Improving soil microbial activity and using microbial synergistic relations, such as arbuscular mycorrhizal fungi (AMF) and plant growth-promoting rhizobacteria... 相似文献
76.
The electrode potential of 2-(4,5-dihydroxy-2-methylphenyl)-2-phenyl-2H-indene-1,3-dione (DMPID) in acetonitrile has been calculated. The calculations were performed using ab initio molecular orbital
calculations (HF), and density functional theory (DFT) with the inclusion of entropic and thermochemical corrections to yield
free energies of redox reactions. The electrode potential of DMPID was also obtained experimentally with the aid of an electrochemical
technique (cyclic voltammetry). The values for geometric parameters and the vibrational frequencies of DMPID and 2-(6-methyl-3,4-dioxocyclohexa-1,5-dienyl)-2-phenyl-2H-indene-1,3-dione
(MDPID) were also computed using the same levels with the basis set of 6-31G(d). The calculated IR spectrum of DMPID used
for the assignment of IR frequencies was observed in the experimental FT-IR spectrum and the calculated IR and FT-IR observed
spectra of DMPID were compared with correlation factor of 0.996. It should be mentioned that the present work is the first
research on coagulant derivative molecules in which the electrode potential of a molecule is calculated.
Optimized structures of 2-(6-methyl-3,4-dioxocyclohexa-1,5-dienyl)-2-phenyl-2H-indene-1,3-dione (MDPID) 相似文献
77.
Sina?Siavash MoghaddamEmail author Rusli?Ibrahim Christos?A.?DamalasEmail author Seyyed?Ali?Noorhosseini 《Journal of Plant Growth Regulation》2017,36(4):957-969
Increased atmospheric CO2 and gamma irradiation have a significant impact on the plant photosynthetic apparatus and organic compound production. In this study, we evaluated the effect of elevated CO2 on the photosynthetic efficiency and production of defensive secondary metabolites (flavonoids) induced by gamma irradiation as a physical elicitor in Centella asiatica. Irradiated and non-irradiated 10-week-old plants of C. asiatica were exposed to 400 and 800 μmol mol?1 of atmospheric CO2 in growth chambers for 2 h every day until six weeks. A CO2-enriched atmosphere initially improved the photosynthetic efficiency and ameliorated the detrimental impact of gamma irradiation on the photosynthetic apparatus, increasing carbon allocation into the flavonoid pathway. Elevated CO2 combined with gamma irradiation resulted in the highest concentration of flavonoids in C. asiatica tissues compared with the other treatments. There was an enhancement in rutin (2.49 fold), naringin (2.15 fold), fisetin (4.07 fold), and morin (4.62 fold) with rising CO2 concentrations from 400 to 800 μmol mol?1 in the irradiated plants. With increasing CO2 concentration, the compensation point and the respiration declined, whereas the apparent quantum yield and the maximum net photosynthesis (A max) rate increased. The efficiency of photosystem II (PSII) was improved in the irradiated plants grown under high concentrations of CO2. The total carbohydrate concentration reached the maximum value at the highest level of CO2, followed by gamma irradiation combined with the highest level of CO2. Irradiated plants of C. asiatica grown under elevated CO2 could be superior to non-irradiated plants due to increased carbon availability both for the flavonoid biosynthesis and for the photosynthetic pathway. 相似文献
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