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111.
In this study, based on the view of statistical inference, we investigate the robustness of neural codes, i.e., the sensitivity
of neural responses to noise, and its implication on the construction of neural coding. We first identify the key factors
that influence the sensitivity of neural responses, and find that the overlap between neural receptive fields plays a critical
role. We then construct a robust coding scheme, which enforces the neural responses not only to encode external inputs well,
but also to have small variability. Based on this scheme, we find that the optimal basis functions for encoding natural images
resemble the receptive fields of simple cells in the striate cortex. We also apply this scheme to identify the important features
in the representation of face images and Chinese characters.
相似文献
Sheng LiEmail: |
112.
Fang-fang Zhuan Zhen-feng Zhang Di-ping Xu Yan-hong Si Han-Zhong Wang Ghopur Mijit 《中国病毒学》2007,22(4):316-325
lacZa-mini-attTn7 was inserted into the intergenic region between the gG and gD genes in a PRV bacterial artificial chromosome (BAC) by homologous
recombination in E. coli. The resulting recombinant BAC (pBeckerZF1) was confirmed by PCR and sequencing. Green fluorescent protein (GFP) gene was
then transposed into pBeckerZF1 by transposon Tn7 to generate pBeckerZF2. Recombinant viruses vBeckerZF1 and vBeckerZF2 were
generated by transfection with the corresponding BAC pBeckerZF1 or pBeckerZF2. The titers and cytopathic effect (CPE) observed
for by vBeckerZF1 and vBeckerZF2 was comparable to that of the parental virus vBecker3. vBeckerZF2 was serial passaged for
five rounds in cell culture, and the mini-Tn7 insertion was stably maintained in viral genome. These results show that recombinant
viruses can be rapidly and reliably created by Tn7-mediated transposition. This technology should accelerate greatly the pace
at which recombinant PRV can be generated and, thus, facilitate the use of recombinant viruses for detailed mutagenic studies.
Foundation item: Key technologies R&D program (2006BAD06A01) from the Ministry of Science and Technology of China. 相似文献
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Si Zhang Zhongnan Yin Fei-Fei Dai Hao Wang Meng-Jiao Zhou Ming-Hui Yang Shu-Feng Zhang Zhi-Feng Fu Ying-Wu Mei Ming-Xi Zang Lixiang Xue 《Journal of cellular physiology》2019,234(8):13252-13262
Although cardiac hypertrophy is widely recognized as a risk factor that leads to cardiac dysfunction and, ultimately, heart failure, the complex mechanisms underlying cardiac hypertrophy remain incompletely characterized. The nuclear receptor peroxisome proliferator-activated receptor δ (PPARδ) is involved in the regulation of cardiac lipid metabolism. Here, we describe a novel PPARδ-dependent molecular cascade involving microRNA-29a (miR-29a) and atrial natriuretic factor (ANF), which is reactivated in cardiac hypertrophy. In addition, we identify a novel role of miR-29a, in which it has a cardioprotective function in isoproterenol hydrochloride-induced cardiac hypertrophy by targeting PPARδ and downregulating ANF. Finally, we provide evidence that miR-29a reduces the isoproterenol hydrochloride-induced cardiac hypertrophy response, thereby underlining the potential clinical relevance of miR-29a in which it may serve as a potent therapeutic target for heart hypertrophy treatment. 相似文献