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91.
A. P. Kaplun O. O. Burdelev N. N. Ivanova Yu. M. Krasnopol’skii V. I. Shvets 《Russian Journal of Bioorganic Chemistry》2000,26(1):60-68
Cerebroside sulfate (CGS) was found to be capable of inhibiting complement-dependent hemolysis. The activity dependence of
CGS-containing liposomes on their composition was studied. Mixtures of CGS with phosphatidylethanolamine, phosphatidylserine,
sphingomyelin from cattle brain, cerebroside from cattle spinal cord (CG), and egg yolk phosphatidylcholine (ePC) were investigated.
In the case of binary CGS/ePC mixtures, the antihemolytic activity varied nonlinearly with an increase in the mass part of
CGS: it sharply increased with an increase in the CGS part from 0.3 to 0.5 and decreased by 20–30% of the maximum value with
an increase in the CGS part from 0.9 to 1. On the basis of these experiments, the optimum distance between the charged groups
of CGS was estimated to be 0.92–1.6 nm. In the ternary compositions of 4:3:3 CGS/ePC/polar lipid, only CG increased the activity
of liposomes as compared to that of liposomes from the 4:6 CGS/ePC. The preliminary incubation of CGS-containing liposomes
with complement decreased hemolysis more effectively than incubation with other components of the hemolytic system. This suggests
that the interaction of CGS-containing liposomes with the complement proteins is responsible for their antihemolytic activity. 相似文献
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T. A. Egorova-Zachernyuk V. I. Shvets K. Versluis W. Heerma A. F. L. Creemers S. A. M. Nieuwenhuis J. Lugtenburg J. Raap 《Journal of peptide science》1996,2(6):341-350
A simple procedure for the preparation of the specifically labelled peptide antibiotic zervamicins IC, IIA and IIB has been developed. The zervamicin molecules are labelled with stable isotopes by culturing the Emericellopsis salmosynnemata on a well-defined synthetic medium containing the highly isotopically enriched amino acid. To obtain the peptide with the specifically and highly enriched amino acid residue, precautions have been taken to prevent any de novo biosynthesis of the particular amino acid from unlabelled precursors. The enrichment of the labelled peptide is determined by mass spectrometric analysis. Following this method we have incorporated [2′,4′, 5′,6′,7′-2H5]-L -Trp-1, [1′-15N]-L -Trp-1 and [2′, 3′,4′,5′,6′-2H5]-L - Phl-16 into zervamicins IC, IIA and IIB on the preparative scale and without scrambling of the label. Thus, using the procedures described, isotopically labelled zervamicins can be prepared, allowing them to be studied by solid- state NMR. 相似文献
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Yu. Berezovskaya M. Chudinov Yu. Kirillova N. Shastina V. Shvets A. Yurkevich 《Nucleosides, nucleotides & nucleic acids》2013,32(9-11):2127-2133
Abstract The structure design of a specific and nonspecific transport systems for nucleosides was proposed. A number of model compounds were synthesized. # AZT-2,3′-dideoxy-3′-azidothymidine. d4T-3′-deoxy-2′,3′-didehydrothymidine, ddC -2,3′-dideoxcytidine. ddI -2′.3′-dideoxyinosine. DMAP-4-N,N-dimetylaminopyridyne, DCC-dicyclohexylcarbodiimide. 相似文献