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21.
Minina AS Sorokoumova GM Selishcheva AA Malikova NM Kalashnikova TIu Shvets VI 《Biofizika》2004,49(4):674-679
The incorporation of rifampicin into multilayer phospholipid vesicles depending on the concentration of antibiotic and phospholipid content was studied. The extent of incorporation of rifampicin into monolayer vesicles (liposomes), obtained by the homogenization of multilamellar vesicles, was determined by the method of gel filtration. It was found that rifampicin better penetrates and is retained in membranes consisting of a mixture of phosphatidylcholine and cardiolipin, the maximum incorporation of rifampicin into liposomes being 17%. It was shown by 31P NMR spectroscopy that, during the interaction of rifampicin with the phospholipid membrane, the bilayer packing of phospholipids is destroyed. 相似文献
22.
S. A. M. Otman A. B. Pshenichnikova V. I. Shvets 《Applied Biochemistry and Microbiology》2012,48(2):200-205
Accelerating growth and increasing exopolysaccharide production in obligate methylotrophic bacterium Methylophilus quaylei were observed in the presence of C12–C18 fatty acids added to the growth media. Sodium oleate was the best growth factor. Based on data on the composition of the
free fatty acids fraction in the cells and the values of the ξ-potential and fluorescence anisotropy of whole cells, we suggested
that fatty acids were incorporated in the outer membrane of M. quaylei. 相似文献
23.
O S Gladysheva D M Kukushkina V A Opritov I M Shvets 《Zhurnal evoliutsionno? biokhimii i fiziologii》1985,21(2):201-203
Bioluminescent analysis has been made of the effect of oxygen supply on the content of ATP in the isolated olfactory epithelium of the frog. It was shown that storage of epithelium preparations in the air increases their ATP content. When preparations are kept in the atmosphere of an inert gas, ATP level in the epithelium rapidly decreases, being recovered after transition of preparations to the air medium. The data obtained indicate the existence of apical type of respiration in the olfactory epithelium of the frog. 相似文献
24.
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26.
A. I. Glukhov L. V. Svinareva S. E. Severin V. I. Shvets 《Applied Biochemistry and Microbiology》2011,47(7):655-660
Telomerase activity is detected in most types of human tumors, but it is almost undetectable in normal somatic cells; therefore,
telomerase is a promising therapeutic target. The present review describes various approaches to telomerase inhibition, namely,
antisense therapy, RNA interference, and the use of ribozymes and agents interacting with the telomeric G-quadruplex. The
use of these compounds in clinical research is analyzed in the review. 相似文献
27.
Nikolay I. Zhurilo Mikhail V. Chudinov Andrey V. Matveev Olga S. Smirnova Irina D. Konstantinova Anatoly I. Miroshnikov Alexander N. Prutkov Lyubov E. Grebenkina Natalya V. Pulkova Vitaly I. Shvets 《Bioorganic & medicinal chemistry letters》2018,28(1):11-14
The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism. 相似文献
28.
Three new saponins, melongosides N, O and P, have been isolated from the methanolic extract of seeds of Solanum melongena and their structures elucidated. Melongoside N is 3-O-[β-D-glucopyranosy l-(1 → 2)-β-D-glucopyranosyl]-26-O-(β-D-glucopyranosyl)-(25R)-5α-furostan-3β,22 α,26-triol, whereas melongoside O is 3-O-[β-D-glucopyranosyl-(1 → 2)β-D-glucopyranosyl]- 26-O-(β-D-glucopyranosyl)-(25R)-furost-5-en-3β,22α,26-triol and melongoside P is 3-O- [β-D-glucopyranosyl-(1 → 2)]-[α-L-rhamnopyranosyl-(1 → 3)]-β-D-glucopyranosyl)-26-O- (β-D-glucopyranosyl)-(25 R)-5α-furostan-3β,22α,26-triol. 相似文献
29.
Iu N Shakina V V Vostrikov G M Sorokoumova A A Selishcheva V I Shvets 《Antibiotiki i khimioterapii͡a》2005,50(7):3-7
Rifabutin solubility within pH 3.0 to 11.0 was determined. Potentiometry, spectrophotometry and computation revealed ionization of three groups with pKa 3.5, 6.5 and 9.5 in the rifabutin molecule. On the basis of the pKa values of certain fragments of the rifabutin molecule computed by the ACD/pKa programme they were related to ionization of the following groups: imidazole residue nitrogen, aromatic hydoxyl and piperidin nitrogen respectively. Interaction of rifabutin with model membranes, i. e. large unilamellar vesicules was studied. At lower pH of the medium, entrapment of rifabutin to the large unilamellar vesicules increased that was evident of satisfactory correlation with the decrease in the rifabutin distribution coefficient in the system multilamellar vesicules/water under the experimental conditions. 相似文献
30.
A study of bacterial surface oligosaccharides were investigated among
different strains of Neisseria gonorrhoeae to correlate structural features
essential for binding to the MAb 2C7. This epitope is widely expressed and
conserved in gonococcal isolates, characteristics essential to an effective
candidate vaccine antigen. Sample lipooligosaccharides (LOS), was prepared
by a modification of the hot phenol-water method from which de-O-acetylated
LOS and oligosaccharide (OS) components were analyzed by ES-MS-CID-MS and
ES-MSnin a triple quadrupole and an ion trap mass spectrometer,
respectively. Previously documented natural heterogeneity was apparent from
both LOS and OS preparations which was admixed with fragments induced by
hydrazine and mild acid treatment. Natural heterogeneity was limited to
phosphorylation and antenni extensions to the alpha-chain. Mild acid
hydrolysis to release OS also hydrolyzed the beta(1-->6) glycosidic
linkage of lipid A. OS structures were determined by collisional and
resonance excitation combined with MS and multistep MSn which provided
sequence information from both neutral loss, and nonreducing terminal
fragments. A comparison of OS structures, with earlier knowledge of MAb
binding, enzyme treatment, and partial acid hydrolysis indicates a generic
overlapping domain for 2C7 binding. Reoccurring structural features include
a Hepalpha(1-->3)Hepbeta(1-->5)KDO trisaccharide core branched on the
nonreducing terminus (Hep-2) with an alpha(1-->2) linked GlcNAc
(gamma-chain), and an alpha-linked lactose (beta-chain) residue. From the
central heptose (Hep-1), a beta(1-->4) linked lactose (alpha-chain),
moiety is required although extensions to this residue appear unnecessary.
相似文献