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91.
Dong-Sheng Han Yoshiji Niimi Shuntaro Kimura 《Plant Cell, Tissue and Organ Culture》2006,85(2):211-217
Bamboos represent one of the world’s great natural and renewable resources. The study reports precocious rhizome formation in multiple shoots of elite, rare, woody bamboo Bambusa bambos var. gigantea. Multiple shoots were initiated from embryonic axes of caryopses inoculated on MS-basal medium supplemented with 5.0 μM BAP and 2% sucrose. Transfer of shoots to MS basal medium supplemented with BAP (2.5 μM, 5.0 μM), GA3 (0.1 μM) and NAA (50.0 μM) and 5% sucrose led to 58% to 100% rhizome induction within four weeks of culture. Subsequently, these rhizomes developed roots on auxin media and formed culm shoots showing regeneration of plantlets after eight weeks. Incorporation of TIBA inhibited rhizome formation. The plantlets with rhizomes were transferred to soil. Precocious rhizome formation will lead to early establishment besides providing propagules on demand and mass multiplication of bamboos through rhizome banks. 相似文献
92.
Huiying Li Fengtian Xue James M. Kraus Haitao Ji Kristin Jansen Labby Jan Mataka Silvia L. Delker Pavel Martásek Linda J. Roman Thomas L. Poulos Richard B. Silverman 《Bioorganic & medicinal chemistry》2013,21(5):1333-1343
Inhibitors of neuronal nitric oxide synthase have been proposed as therapeutics for the treatment of different types of neurological disorders. On the basis of a cis-3,4-pyrrolidine scaffold, a series of trans-cyclopropyl- and methyl-containing nNOS inhibitors have been synthesized. The insertion of a rigid electron-withdrawing cyclopropyl ring decreases the basicity of the adjacent amino group, which resulted in decreased inhibitory activity of these inhibitors compared to the parent compound. Nonetheless, three of them exhibited double-digit nanomolar inhibition with high nNOS selectivity on the basis of in vitro enzyme assays. Crystal structures of nNOS and eNOS with these inhibitors bound provide a basis for detailed structure–activity relationship (SAR) studies. The conclusions from these studies will be used as a guide in the future development of selective NOS inhibitors. 相似文献