全文获取类型
收费全文 | 1563篇 |
免费 | 67篇 |
出版年
2023年 | 5篇 |
2022年 | 8篇 |
2021年 | 17篇 |
2020年 | 7篇 |
2019年 | 8篇 |
2018年 | 25篇 |
2017年 | 14篇 |
2016年 | 23篇 |
2015年 | 38篇 |
2014年 | 54篇 |
2013年 | 93篇 |
2012年 | 86篇 |
2011年 | 100篇 |
2010年 | 64篇 |
2009年 | 48篇 |
2008年 | 70篇 |
2007年 | 107篇 |
2006年 | 81篇 |
2005年 | 88篇 |
2004年 | 107篇 |
2003年 | 89篇 |
2002年 | 106篇 |
2001年 | 24篇 |
2000年 | 17篇 |
1999年 | 20篇 |
1998年 | 17篇 |
1997年 | 31篇 |
1996年 | 17篇 |
1995年 | 12篇 |
1994年 | 16篇 |
1993年 | 18篇 |
1992年 | 21篇 |
1991年 | 19篇 |
1990年 | 15篇 |
1989年 | 13篇 |
1988年 | 9篇 |
1987年 | 10篇 |
1986年 | 14篇 |
1984年 | 4篇 |
1983年 | 11篇 |
1982年 | 12篇 |
1981年 | 22篇 |
1980年 | 19篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1977年 | 10篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1969年 | 4篇 |
排序方式: 共有1630条查询结果,搜索用时 312 毫秒
81.
New chiral ferrocenyl ligands having chiral sulfinyl and phosphinyl groups were prepared. The palladium-catalyzed allylic substitution reaction using these chiral ligands showed good enantioselectivity. The mechanism for the asymmetric reaction is proposed on the basis of the stereochemical outcome. 相似文献
82.
83.
Dof domain proteins: plant-specific transcription factors associated with diverse phenomena unique to plants 总被引:22,自引:0,他引:22
Yanagisawa S 《Plant & cell physiology》2004,45(4):386-391
84.
85.
Yano S 《Experimental & applied acarology》2004,32(4):243-248
Whether the spider mite Tetranychus urticae uses flying insects as vectors for phoretic dispersal was experimentally tested. Two bean plants were placed in a microcosm, and a mite population was introduced onto one of the plants. Either Phaenicia cuprina Wiedemann (Diptera: Calliphoridae) or Helicoverpa armigera Hübner (Lepidoptera: Noctuidae) was then introduced into the microcosms as a hypothetical vector insect. T. urticae populations on the second bean plant were monitored to detect any evidence of phoretic dispersal. Instances of dispersal were detected at extremely low frequency, suggesting that phoretic dispersal of T. urticae mediated by winged insects is probably rare in the wild. 相似文献
86.
Toshima K Ozawa T Kimura T Matsumura S 《Bioorganic & medicinal chemistry letters》2004,14(11):2777-2779
The novel DNA interactive quinoxaline-carbohydrate hybrids possessing disaccharides as the carbohydrate moieties were designed and synthesized, and their DNA photocleaving abilities were evaluated in order to examine the effect of the disaccharide structures. The configurations of the glycosidic bonds in the disaccharide strongly affected the DNA photocleaving ability, and two beta-glycosidic bond linkages were very effective for the DNA photocleavage. Furthermore, the quinoxaline-disaccharide hybrids exhibited selective cytotoxicity against cancer cells with photoirradiation. 相似文献
87.
Noriko Okazaki Reiko Kikuno Reiko Ohara Susumu Inamoto Haruhiko Koseki Shuichi Hiraoka Yumiko Saga Hiroshi Kitamura Tomoko Nakagawa Takahiro Nagase Osamu Ohara Hisashi Koga 《DNA research》2004,11(2):127-135
We have been conducting a mouse cDNA project to predict protein-coding sequences of mouse KIAA-homologous genes since 2001. As an extension of this project, we also started to accumulate mouse cDNA clones homologous to the human FLJ cDNA clones which are another long cDNA resource produced in our institute. We have isolated the cDNA clones from size-fractionated cDNA libraries derived from five different mouse tissues and natural killer T-cells. Although the human FLJ cDNA clones were originally derived from human spleen libraries, one-third of their mouse homologues were obtained from the brain library. We designated these homologues "mFLJ" plus a 5-digit number and herein characterized 110 mFLJ cDNA clones. We assigned an integrity of the CDSs from the comparison of the 110 cDNA clones with the corresponding human FLJ cDNA clones. The average size of the 110 mouse cDNA sequences was 3.8 kb and that of the deduced amino acid sequences from their longest CDS in each cDNA was 663 amino acid residues. Homology and/or motif search against public databases revealed new domains and/or motifs in 26 mFLJ gene products which provide additional speculation regarding the function of FLJ genes. 相似文献
88.
We have found that cover scales on the wing of the butterfly Morpho didius possess specially designed microscopic structures for wavelength-selective reflection and contribute considerably to the brilliant blue colour of the wing. In addition, the cover scale functions as an anisotropic optical diffuser which diffuses light only in one plane, while it makes the range of reflection narrower in the orthogonal plane. The quantitative analyses for the wavelength-selection mechanism and the peculiar optical diffuser are given and the role of such a special optical effect is discussed from physical and biological viewpoints. 相似文献
89.
Absence of the candidate male sex-determining gene dmrt1b(Y) of medaka from other fish species 总被引:12,自引:0,他引:12
Kondo M Nanda I Hornung U Asakawa S Shimizu N Mitani H Schmid M Shima A Schartl M 《Current biology : CB》2003,13(5):416-420
Although the sex-determining genes are known in mammals, Drosophila, and C. elegans, little is known in other animals. Fishes are an attractive group of organisms for studying the evolution of sex determination because they show an amazing variety of mechanisms, ranging from environmental sex determination and different forms of hermaphroditism to classical sex chromosomal XX/XY or WZ/ZZ systems and modifications thereof. In the fish medaka, dmrt1b(Y) has recently been found to be the candidate male sex-determining gene. It is a duplicate of the autosomal dmrt1a gene, a gene acting in the sex determination/differentiation cascade of flies, worms, and mammals. Because in birds dmrt1 is located on the Z-chromosome, both findings led to the suggestion that dmrt1b(Y) is a "non-mammalian Sry" with an even more widespread distribution. However, although Sry was found to be the male sex-determining gene in the mouse and some other mammalian species, in some it is absent and has obviously been replaced by other genes that now fulfil the same function. We have asked if the same might be true of the dmrt1b(Y) gene. We find that the gene duplication generating dmrt1b(Y) occurred recently during the evolution of the genus Oryzias. The gene is absent from all other fish species studied. Therefore, it may not be the male-sex determining gene in all fishes. 相似文献
90.
Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors 总被引:2,自引:0,他引:2
Ishihara T Kakuta H Moritani H Ugawa T Sakamoto S Tsukamoto S Yanagisawa I 《Bioorganic & medicinal chemistry》2003,11(11):2403-2414
Squalene synthase (E.C. 2.5.1.21) catalyses the reductive dimerization of two molecules of farnesyl diphosphate to form squalene and is involved in the first committed step in cholesterol biosynthesis. Inhibition of this enzyme is therefore an attractive target for hypocholesterolemic strategies. A series of quinuclidine derivatives incorporating a tricyclic system was synthesized and evaluated for their ability to inhibit squalene synthase in vitro. A 9H-fluorene moiety was found to be optimal as the tricyclic system for potent inhibitory activity. Improved activity can be achieved with a conformationally constrained three-atom linkage connecting the tricyclic system with the quinuclidine nucleus. Among these compounds, (Z)-3-[2-(9H-fluoren-2-yloxy)ethylidene]-quinuclidine hydrochloride 31 was found to be a potent inhibitor of squalene synthase derived from hamster liver and human hepatoma cells with IC(50) values of 76 and 48 nM, respectively. Oral dosing of compound 31 demonstrated effective reduction of plasma non-HDL cholesterol levels in hamsters. 相似文献