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191.
Shu Q. Liu 《Molecular & cellular biomechanics : MCB》2019,16(2):75-85
Ischemic stroke, although causing brain infarction and neurological deficits, can activate innate neuroprotective mechanisms, including regional mechanisms within the ischemic brain and distant mechanisms from non-ischemic organs such as the liver, spleen, and pancreas, supporting neuronal survival, confining brain infarction, and alleviating neurological deficits. Both regional and distant mechanisms are defined as systems neuroprotective mechanisms. The regional neuroprotective mechanisms involve release and activation of neuroprotective factors such as adenosine and bradykinin, inflammatory responses, expression of growth factors such as nerve growth factors and neurotrophins, and activation and differentiation of resident neural stem cells to neurons and glial cells. The distant neuroprotective mechanisms are implemented by expression and release of endocrine neuroprotective factors such as fibroblast growth factor 21, resistin like molecule γ, and trefoil factor 3 from the liver; brain-derived neurotrophic factor and nerve growth factor from the spleen; and neurotrophin 3 and vascular endothelial growth factor C from the pancreas. Furthermore, ischemic stroke induces mobilization of bone marrow hematopoietic stem cells and endothelial progenitor cells into the circulatory system and brain, contributing to neuroprotection. The regional and distant mechanisms may act in coordination and synergy to protect the ischemic brain from injury and death. This paper addresses these mechanisms and associated signaling networks. 相似文献
192.
Shu Chien 《Molecular & cellular biomechanics : MCB》2019,16(3):163-178
Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, by setting the highest standards, through educating many students and their students, and providing his exemplary leadership. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the foundations of biomechanics in living tissues and organs. Through his vision of the power of “making models” to explain and predict biological phenomena, Dr. Fung opened up new vista for bioengineering, from organs-systems to molecules-genes, and has provided the foundation of research activities in many institutions in the United States and the world. He has made outstanding contributions to education in bioengineering, service to professional organizations, and translation to industry and clinical medicine. He is widely recognized as the Father of Biomechanics and the leading Bioengineer in the world. His extraordinary achievements and commands in science, engineering and the arts make him a Renaissance Man for the world. 相似文献
193.
Zhe Hu Zhixin Tai Qiannan Liu Shi‐Wen Wang Huile Jin Shun Wang Weihong Lai Mingzhe Chen Lin Li Lingna Chen Zhanliang Tao Shu‐Lei Chou 《Liver Transplantation》2019,9(8)
Sodium ion batteries are now attracting great attention, mainly because of the abundance of sodium resources and their cheap raw materials. 2D materials possess a unique structure for sodium storage. Among them, transition metal chalcogenides exhibit significant potential for rechargeable battery devices due to their tunable composition, remarkable structural stability, fast ion transport, and robust kinetics. Herein, ultrathin TiS2 nanosheets are synthesized by a shear‐mixing method and exhibit outstanding cycling performance (386 mAh g?1 after 200 cycles at 0.2 A g?1). To clarify the variations of galvanostatic curves and superior cycling performance, the mechanism and morphology changes are systematically investigated. This facile synthesis method is expected to shed light on the preparation of ultrathin 2D materials, whose unique morphologies could easily enable their application in rechargeable batteries. 相似文献
194.
Zhang Jun Jiang Tingting Liang Xiujie Shu Shuangshuang Xiang Xiaohong Zhang Wenying Guo Tingting Xie Wei Deng Weiqian Tang Xun 《Journal of physiology and biochemistry》2019,75(4):443-452
Journal of Physiology and Biochemistry - Epithelial-to-mesenchymal transition (EMT) and injury of tubular cells play critical roles in the pathogenesis of diabetic nephropathy (DN). lncRNA... 相似文献
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Tai‐Wen Lin Chi‐Chih Chen Shu‐Mei Wu Yu‐Ching Chang Yi‐Chuan Li Yu‐Wang Su Chwan‐Deng Hsiao Hsin‐Yang Chang 《The Plant journal : for cell and molecular biology》2019,99(1):128-143
In mammals and yeast, tail‐anchored (TA) membrane proteins destined for the post‐translational pathway are safely delivered to the endoplasmic reticulum (ER) membrane by a well‐known targeting factor, TRC40/Get3. In contrast, the underlying mechanism for translocation of TA proteins in plants remains obscure. How this unique eukaryotic membrane‐trafficking system correctly distinguishes different subsets of TA proteins destined for various organelles, including mitochondria, chloroplasts and the ER, is a key question of long standing. Here, we present crystal structures of algal ArsA1 (the Get3 homolog) in a distinct nucleotide‐free open state and bound to adenylyl‐imidodiphosphate. This approximately 80‐kDa protein possesses a monomeric architecture, with two ATPase domains in a single polypeptide chain. It is capable of binding chloroplast (TOC34 and TOC159) and mitochondrial (TOM7) TA proteins based on features of its transmembrane domain as well as the regions immediately before and after the transmembrane domain. Several helices located above the TA‐binding groove comprise the interlocking hook‐like motif implicated by mutational analyses in TA substrate recognition. Our data provide insights into the molecular basis of the highly specific selectivity of interactions of algal ArsA1 with the correct sets of TA substrates before membrane targeting in plant cells. 相似文献
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Jingting Shu Gaige Ji Ming Zhang Yunjie Tu Yanju Shan Yifan Liu 《Animal biotechnology》2019,30(2):118-128
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