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71.
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The maximal endothelial dependent relaxation of isolated aortic rings to cumulative doses of acetylcholine was significantly decreased in the Cyclosporine-A (CSA, 20 mg kg(-1) day(-1)) treated animals compared to olive oil (CSA vehicle) treated control. Administration of antihypertensive drugs like diltiazem, enalapril or propranolol to CSA treated animals augmented the endothelial damage induced by CSA. These drugs also increased the bioavailability of CSA. However, administration of losartan to CSA treated animals produced a significant increase in endothelial dependent relaxation as compared to CSA treated control but did not affect the bioavailability of CSA significantly. The results suggest that losartan is safer compared to other antihypertensives for the treatment of CSA induced hypertension. 相似文献
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The present work embodies epidermal structure, structure and ontogeny of stomata in five genera embracing sixteen species of the Capparidaceae namely Cleome (8 species) Capparis (5 species), Cadaba (1 species), Crataeva (1 species) and Maerua (1 species). The epidermal cells are polygonal, isodiametric or elongated arranged irregularly, with evenly or unevenly thickened, sinuous, straight or arched anticlinal walls. Two main types of trichomes: glandular (four types) and eglandular (five types) are noticed. The stomatal types include cyclocytic, triacytic, staurocytic, tetracytic, anomocytic, anisocytic, paracytic and with a single subsidiary cell. The ontogeny of stomata with a single subsidiary cell is perigenous or mesoperigenous, of paracytic mesoperigenous or mesogenous, of anisocytic is mesoperigenous or mesogenous, while that of the other types is perigenous. Abnormalities observed are: single guard cell; aborted guard cells; complete or incomplete division of guard cells; contiguous stomata; giant stomata and cytoplasmic connections. The present observations do not support the separation of Cleomaceae from the Capparidaceae. 相似文献
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B. Mackler B. Haynes A.R. Inamdar L.R. Pedegana J.G. Hall M.M. Cohen 《Archives of biochemistry and biophysics》1973,159(2):885-888
Defective oxidative energy formation (with decreased phosphorylation possibly occurring at Site I of phosphorylation, the NADH dehydrogenase region of the terminal respiratory system) has been demonstrated in mitochondrial preparations isolated from muscle biopsy specimens from human subjects with classical achondroplasia. 相似文献
77.
Chachadi Vishwanath B. Pujari Radha Shastry Padma Swamy Bale M. Inamdar Shashikala R. 《Glycoconjugate journal》2020,37(2):251-261
Glycoconjugate Journal - Sclerotium rolfsii lectin (SRL) exerts apoptotic effect against various cancer cells and an antitumor activity on mice with colon and breast cancer xenografts. The current... 相似文献
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Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease 总被引:1,自引:0,他引:1
The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome for meaningful therapeutic outcomes is challenging due to the limited control of cytokine production following their transplantation. This review outlines the current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease. We discuss ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation in greater detail. Finally, we provide insights on and perspectives for future development of the MSC secretome as a therapeutic tool. 相似文献
80.
Christopher K. Boccia Lindsey Swierk Fernando P. Ayala-Varela James Boccia Isabela L. Borges Camilo Andres Estupiñán Alexandra M. Martin Ramón E. Martínez-Grimaldo Sebastian Ovalle Shreeram Senthivasan Ken S. Toyama María del Rosario Castañeda Andrés García Richard E. Glor D. Luke Mahler 《Current biology : CB》2021,31(13):2947-2954.e4
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