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41.
Multiplicity of the interactions of Wnt proteins and their receptors 总被引:11,自引:0,他引:11
Wnts are secreted proteins that are essential for a wide array of developmental and physiological processes. They signal across the plasma membranes by interacting with serpentine receptors of the Frizzled (Fz) family and members of the low-density-lipoprotein receptor-related protein (LRP) family. Recent advances in the Wnt signaling field have revealed that Wnt-unrelated proteins activate or suppress Wnt signaling by binding to Fzs or LRP5/6 and that atypical receptor tyrosine kinases mediate Wnt signaling independently of Fz and/or function as a Fz co-receptor. This review highlights recent progress in our understanding of the multiplicity of Wnts and their receptors. We discuss how the interaction between the ligands and receptors activate distinct intracellular signaling pathways. We also discuss how intracellular trafficking of Wnt signaling components can regulate the sensitivity of cells to Wnts. 相似文献
42.
Yoshida Naofumi Morinaga Shin-Ichi Wakamiya Takeshi Ishii Yuu Kubota Shosei Hikosaka Kouki 《Journal of plant research》2023,136(2):183-199
Journal of Plant Research - Adaptive divergence occurs even between insufficiently isolated populations when there is a great difference in environments between their habitats. Individuals present... 相似文献