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排序方式: 共有174条查询结果,搜索用时 15 毫秒
11.
Katherine M. Partridge Stephen Antonysamy Shobha N. Bhattachar Srinivasan Chandrasekhar Matthew J. Fisher Adrian Fretland Karen Gooding Anita Harvey Norman E. Hughes Steven L. Kuklish John G. Luz Peter R. Manninen James E. McGee Daniel R. Mudra Antonio Navarro Bryan H. Norman Steven J. Quimby Matthew A. Schiffler Xiao-Peng Yu 《Bioorganic & medicinal chemistry letters》2017,27(6):1478-1483
We describe a novel class of acidic mPGES-1 inhibitors with nanomolar enzymatic and human whole blood (HWB) potency. Rational design in conjunction with structure-based design led initially to the identification of anthranilic acid 5, an mPGES-1 inhibitor with micromolar HWB potency. Structural modifications of 5 improved HWB potency by over 1000×, reduced CYP2C9 single point inhibition, and improved rat clearance, which led to the selection of [(cyclopentyl)ethyl]benzoic acid compound 16 for clinical studies. Compound 16 showed an IC80 of 24 nM for inhibition of PGE2 formation in vitro in LPS-stimulated HWB. A single oral dose resulted in plasma concentrations of 16 that exceeded its HWB IC80 in both rat (5 mg/kg) and dog (3 mg/kg) for over twelve hours. 相似文献
12.
Swamy BP Kaladhar K Shobha Rani N Prasad GS Viraktamath BC Reddy GA Sarla N 《The Journal of heredity》2012,103(3):442-452
The appearance and cooking quality of rice determine its acceptability and price to a large extent. Quantitative trait loci (QTLs) for 12 grain quality traits were mapped in 2 mapping populations derived from Oryza sativa cv Swarna × O. nivara. The BC(2)F(2) population of the cross Swarna × O. nivara IRGC81848 (population 1) was evaluated during 2005 and that from Swarna × O. nivara IRGC81832 (population 2) was evaluated during 2006. Linkage maps were constructed using 100 simple sequence repeat (SSR) markers in population 1 and 75 SSR markers in population 2. In all, 21 QTLs were identified in population 1 (43% from O. nivara) and 37 in population 2 (38% QTLs from O. nivara). The location of O. nivara-derived QTLs mp1.2 for milling percent, kw6.1 for kernel width, and klac12.1 for kernel length after cooking coincided in the 2 populations and appear to be useful for Marker Assisted Selection (MAS). Four QTLs for milling percent, 1 QTL each for amylose content, water uptake, elongation ratio, 2 QTLs for kernel width, and 3 QTLs for gel consistency, each explained more than 20% phenotypic variance. Three QTL clusters for grain quality traits were close to the genes/QTLs for shattering and seed dormancy. QTLs for 4 quality traits were associated with 5 of the 7 major yield QTLs reported in the same 2 mapping populations. Useful introgression lines have been developed for several agronomic traits. It emerges that 40% O. nivara alleles were trait enhancing in both populations, and QTLs for grain quality overlapped with yield meta-QTLs and QTLs for dormancy and seed shattering. 相似文献
13.
A new polyhydroxy pregnane designated as cissogenin has been isolated from the seeds of Marsdenia tenacissima. Its structure has been established as 3β,11α,12β,14β,20 S-pentahydroxy-pregn-5-ene. 相似文献
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15.
D. A. B. Rex Shobha Dagamajalu Mahesh Manjunath Gouda G. P. Suchitha Jaikanth Chanderasekaran Rajesh Raju T. S. Keshava Prasad Yashodhar Prabhakar Bhandary 《Journal of cell communication and signaling》2023,17(1):209
Interleukin-17A (IL-17A) is one of the member of IL-17 family consisting of other five members (IL-17B to IL-17F). The Gamma delta (γδ) T cells and T helper 17 (Th17) cells are the major producers of IL-17A. Aberrant signaling by IL-17A has been implicated in the pathogenesis of several autoimmune diseases including idiopathic pulmonary fibrosis, acute lung injury, chronic airway diseases, and cancer. Activation of the IL-17A/IL-17 receptor A (IL-17RA) system regulates phosphoinositide 3-kinase/AKT serine/threonine kinase/mammalian target of rapamycin (PI3K/AKT/mTOR), mitogen-activated protein kinases (MAPKs) and activation of nuclear factor-κB (NF-κB) mediated signaling pathways. The IL-17RA activation orchestrates multiple downstream signaling cascades resulting in the release of pro-inflammatory cytokines such as interleukins (IL)-1β, IL-6, and IL-8, chemokines (C-X-C motif) and promotes neutrophil-mediated immune response. Considering the biomedical importance of IL-17A, we developed a pathway resource of signaling events mediated by IL-17A/IL-17RA in this study. The curation of literature data pertaining to the IL-17A system was performed manually by the NetPath criteria. Using data mined from the published literature, we describe an integrated pathway reaction map of IL-17A/IL-17RA consisting of 114 proteins and 68 reactions. That includes detailed information on IL-17A/IL-17RA mediated signaling events of 9 activation/inhibition events, 17 catalysis events, 3 molecular association events, 68 gene regulation events, 109 protein expression events, and 6 protein translocation events. The IL-17A signaling pathway map data is made freely accessible through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway: WP5242).Supplementary InformationThe online version contains supplementary material available at 10.1007/s12079-022-00686-y. 相似文献
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High-temperature biotrickling filtration of hydrogen sulphide 总被引:1,自引:0,他引:1
Biofiltration of malodorous reduced sulphur compounds such as hydrogen sulphide has been confined to emissions that are at
temperatures below 40°C despite the fact that there are many industrial emissions (e.g. in the pulp and paper industry) at
temperatures well above 40°C. This paper describes our study on the successful treatment of hydrogen sulphide gas at temperatures
of 40, 50, 60 and 70°C using a microbial community obtained from a hot spring. Three biotrickling filter (BTF) systems were
set up in parallel for a continuous run of 9 months to operate at three different temperatures, one of which was always at
40°C as a mesophilic control and the other two were for exploring high-temperature operation up to 70°C. The continuous experiment
and a series of batch experiments in glass bottles (250 ml) showed that addition of glucose and monosodium glutamate enhanced
thermophilic biofiltration of hydrogen sulphide gas and a removal rate of 40 g m−3 h−1 was achieved at 70°C. We suggest that the glucose is acting as a carbon source for the existing microbial community in the
BTFs, whereas glutamate is acting as a compatible solute. The use of such organic compounds to enhance biodegradation of hydrogen
sulphide, particularly at high temperatures, has not been demonstrated to our knowledge and, hence, has opened up a range
of possibilities for applying biofiltration to hot gas effluent. 相似文献
18.
Bhaskar JJ Shobha MS Sambaiah K Salimath PV 《Journal of physiology and biochemistry》2011,67(3):415-425
Diabetes is a chronic health problem and major cause of death in most of the countries. Diet management plays an important
role in controlling diabetes and its complications along with insulin and drugs. We have examined the effect of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced
diabetic rats. Our results indicated that banana flower and pseudostem have low glycemic index and have a high content of
dietary fiber and antioxidants. Diabetic symptoms like hyperglycemia, polyuria, polyphagia, polydipsia, urine sugar, and body
weight were ameliorated in banana flower- and pseudostem-treated rats. Increased glomerular filtration rate in the diabetic
group (5.1 ± 0.22 ml/min) was decreased in banana flower-fed (2.5 ± 0.37 ml/min) and pseudostem-fed (3.0 ± 0.45 ml/min) groups
and were significant at P < 0.001 and P < 0.01, respectively. Fructosamine and AGEs formed during diabetes were inhibited in treated groups when compared with the
diabetic group. The diabetic group showed 11.5 ± 0.64 μg of AGEs/mg protein in kidney, whereas, in banana flower- and pseudostem-fed
groups, it was reduced to 9.21 ± 0.32 and 9.29 ± 0.24 μg/mg protein, respectively, and were significant at P < 0.01. These findings suggest that banana flower and pseudostem have anti-diabetic and anti-AGEs properties and are beneficial
as food supplements for diabetics. 相似文献
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20.
Wissam A. Abou-Alaiwi Shobha D. Potlakayala Stephen L. Goldman Puthiyaparambil C. Josekutty Deepkamal N. Karelia Sairam V. Rudrabhatla 《Plant Cell, Tissue and Organ Culture》2012,109(1):1-8
An efficient transformation system was developed for Centaurea montana by co-cultivation of leaf explants with Agrobacterium tumefaciens strain AGL1 that contained a plasmid harboring the isopentenyl transferase gene under the control of the developmentally
regulated Atmyb32 promoter of Arabidopsis thaliana and the gene encoding for hygromycin resistance under the control of the Cauliflower Mosaic Virus 35S (CaMV35S) promoter.
A total of 990 explants were infected with Agrobacterium, and 18 shoots were regenerated resulting in an overall transformation efficiency of 1.8%. Molecular analyses, including
PCR, Southern blotting and RT-PCR, were performed on T0 and T1 plants to confirm chromosomal integration and expression of the transgene in the phenotypically normal transformed plants.
Transformation of C. montana was also performed using A. tumefaciens supervirulent strain EHA105 harboring the β-glucuronidase (GUS) reporter gene. Expression of the GUS gene in the putative transgenics was confirmed using a histochemical GUS assay. 相似文献