全文获取类型
收费全文 | 326篇 |
免费 | 31篇 |
出版年
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 4篇 |
2017年 | 4篇 |
2016年 | 4篇 |
2015年 | 17篇 |
2014年 | 7篇 |
2013年 | 19篇 |
2012年 | 20篇 |
2011年 | 18篇 |
2010年 | 7篇 |
2009年 | 7篇 |
2008年 | 14篇 |
2007年 | 9篇 |
2006年 | 27篇 |
2005年 | 17篇 |
2004年 | 16篇 |
2003年 | 23篇 |
2002年 | 18篇 |
2001年 | 2篇 |
2000年 | 3篇 |
1998年 | 5篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 8篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1973年 | 7篇 |
1972年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有357条查询结果,搜索用时 15 毫秒
121.
Adrian Shulman Eric Jauniaux Anna Holmes Shlomo Maschiach Ron Maymon 《Twin research》2002,5(4):255-259
The present study aimed to determine a reliable tool to estimate the interval time to delivery in assisted conception twin pregnancies. Mid-gestation cervical length was prospectively measured using transvaginal sonography (TVS) during routine antenatal care. Fifty-seven of 101 suitable women were longitudinally followed and two TVS measurements of their cervical length were obtained, first at approximately 24 weeks gestation and then at approximately 27 weeks gestation. The mean cervical length decreased from 37 +/- 12mm at first measurement to 34 +/- 11mm at the second one. A linear regression model was found between the time interval of the first (R = 0.656, p < 0.001) and the second (R = 0.435, p < 0.001) assessments and the week of delivery. The current data confirm that the length of the preserved segment of the cervix is an important indicator of its competence. A simple equation using the cervical length (mm) divided by 3 can predict mid gestation scan-to-delivery interval in twin gestation. 相似文献
122.
Both melatonin and DSIP (a nine amino acid peptide) effects have been previously shown to be (a) circadian rhythm related and (b) involved in inducing hypothermic effects in rats. In this study we report the hypothermia effects by each of these drugs alone and in combination when studied in normal (unoperated), pinealectomized, and hypophysectomized rats at various time points of the corresponding circadian cycle. A clear differential effect of drugs × time × preparation was found. While both DSIP and melatonin hypothermic effects were both circadian cycle dependent in intact rats the rhythmicity of melatonin hypothermic effect in pinealectomized rats, and DSIP hypothermic effect in hypophysectomized rats was missing. Although several hypotheses have been offered to account for the physiological mechanism(s) that govern the effects of the drugs, it is not yet possible to reliably relate the findings to existing neurochemical theory. 相似文献
123.
Kinetics of Ca2+-induced fusion of phosphatidylserine vesicles is studiied for lipid concentrations varying from 1 μM to 100 μM. Fusion is monitored by mixing of aqueous vesicle contents and by explicitly accounting for leakage. The analysis provides separately rates of aggregation and fusion. The rate of fusion per se decreases steeply with vesicle size. 相似文献
124.
Shlomo Lustig Pnina Fishman Meir Djaldetti Dov H. Pluznik 《Experimental cell research》1980,129(2):321-328
Experiments with synchronous cultures of murine mastocytoma cells indicated that cells incubated with wheat germ agglutinin (WGA) responded with cap formation and cytolysis during the mitotic phase only, but not during the G1, S and G2 phases of the cell cycle. The telophase of mitosis was found to be most sensitive to the cytolytic effect of WGA. Addition of the lectin to cells enhanced movement of the lectin-binding sites to the cleavage furrow during the telophase, as demonstrable by the concentration of fluorescent lectin and microvilli in this region. This phenomenon was followed by osmotic lysis of the cells which could be prevented by addition to the medium of dextran of high molecular weight. 相似文献
125.
The binding of mono-, di- and trivalent cations to negatively charged surfaces is studied within the framework of a modified
Gouy-Chapman equation. For any given combination of ions of the above valences, the existence and uniqueness of the solution
for the surface potential is shown. The treatment provides the surface potential and charge density. For a system containing
only monovalent and divalent ions, analytical solutions are given. When trivalent ions are also present, a procedure based
on numerical integration is described. The distance dependence of the electrostatic potential for planar surfaces is given.
The calculations provide the amount of cations tightly bound and the amount trapped in the double layer region. The competition
between cations for binding to surfaces is elucidated. 相似文献
126.
127.
Shlomo Burstein R.C. Nickolson Chang Y. Byon Howard L. Kimball Marcel Gut 《Steroids》1977,30(4):439-453
Incubation of lanosta-8, 24-dien-3β-o1-1,2- 3H and lanost-8-en-3β-o1-1, 2-3H with an adrenocortical bovine mitochondrial acetone-dried preparation did not yield any significant ( < 0.01%) 3β-hydroxy-4, 4, 14-trimethyl-5α-pregn-8-en-20-one. Under the same conditions cholesterol-1,2-3H yielded 8.3% pregnenolone. Incubation of (20S?) — 17α, 20-dihydroxycholesterol-7-3 H yielded 0.6 to 1.6% (20SS?, 22R?) — 17α, 20, 22-trihydroxycholesterol, 1.0 to 3.2% of 17α-hydroxypregnenolone, but no significant ( < 0.02%) (20S, 22S)-17α, 20, 22-trihydroxycholesterol. In another experiment incubation of cholesterol-1, 2-3H yielded 5% pregnenolone, 0.5% 17α-hydroxypregnenolone, 0.2% (20R?,22R?)-20, 22-dihydroxy-cholesterol, but no significant ( < 0.01%) 17α-hydroxy-cholesterol, (20S?) -17α, 20-dihydroxycholesterol or (20S?, 22R?)-17α, 20, 22-trihydroxycholesterol. 相似文献
128.
Robert Bittman Shlomo Rottem 《Biochemical and biophysical research communications》1976,71(1):318-324
Rapid kinetic studies of filipin binding to intact cells and isolated membranes were performed with a stopped-flow apparatus to determine the distribution of cholesterol in the outer and inner surfaces of mycoplasma membranes. The initial rates of association of filipin with cholesterol in Mycoplasma gallisepticum and Mycoplasma capricolum intact cells were slower than those obtained with isolated membrane preparations. Ratios of the second-order rate constants for filipin binding to cells relative to membranes indicate that cholesterol is distributed symmetrically in membranes of M. gallisepticum cells whereas in M. capricolum ~66% of the free cholesterol is localized in the outer half of the lipid bilayer. 相似文献
129.
Shlomo Wientroub Larry W. Fisher A. Hari Reddi John D. Termine 《Molecular and cellular biochemistry》1987,74(2):157-162
Rats were raised in the absence of vitamin D in utero and throughout post-fetal life and neither 1,25-dihydroxyvitamin D3 nor related metabolites were detected in serums. No changes were observed in the relative amount of extractable noncollagenous bone proteins (NCP) in rachitic compared to vitamin-D-repleted animals. As expected, the relative levels of the mineral-bound, serum-derived albumin and 2-HS glycoprotein were unaffected in bones of rachitic animals. Interestingly, the vitamin D deficiency also did not have dramatic effects on several bone cell-derived noncollagenous proteins including: bone proteoglycans I & 11, bone sialoprotein li osteonectin, and osteocalcin. In contrast to the proteoglycans, the bone sialoprotein II and osteonectin were found in the nonmineral compartment of the rachitic animals, presumably bound to the wide osteoid seam. 相似文献
130.
Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy 总被引:9,自引:0,他引:9
下载免费PDF全文
![点击此处可从《American journal of human genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Greenberg DA Cayanis E Strug L Marathe S Durner M Pal DK Alvin GB Klotz I Dicker E Shinnar S Bromfield EB Resor S Cohen J Moshe SL Harden C Kang H 《American journal of human genetics》2005,76(1):139-146
Idiopathic generalized epilepsy (IGE) is a class of genetically determined, phenotypically related epilepsy syndromes. Linkage analysis identified a chromosome 18 locus predisposing to a number of adolescent-onset IGEs. We report a single-nucleotide polymorphism (SNP) association analysis of the region around the marker locus with the high LOD score. This analysis, which used both case-control and family-based association methods, yielded strong evidence that malic enzyme 2 (ME2) is the gene predisposing to IGE. We also observed association among subgroups of IGE syndromes. An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype. Both the linkage analysis and the association analysis support recessive inheritance for the locus, which is compatible with the fact that ME2 is an enzyme. ME2 is a genome-coded mitochondrial enzyme that converts malate to pyruvate and is involved in neuronal synthesis of the neurotransmitter gamma-aminobutyric acid (GABA). The results suggest that GABA synthesis disruption predisposes to common IGE and that clinical seizures are triggered when mutations at other genes, or perhaps other insults, are present. 相似文献