全文获取类型
收费全文 | 1235篇 |
免费 | 28篇 |
出版年
2023年 | 3篇 |
2022年 | 11篇 |
2021年 | 12篇 |
2020年 | 13篇 |
2019年 | 5篇 |
2018年 | 6篇 |
2017年 | 10篇 |
2016年 | 20篇 |
2015年 | 23篇 |
2014年 | 35篇 |
2013年 | 87篇 |
2012年 | 60篇 |
2011年 | 66篇 |
2010年 | 44篇 |
2009年 | 56篇 |
2008年 | 72篇 |
2007年 | 83篇 |
2006年 | 100篇 |
2005年 | 77篇 |
2004年 | 79篇 |
2003年 | 75篇 |
2002年 | 92篇 |
2001年 | 11篇 |
2000年 | 9篇 |
1999年 | 18篇 |
1998年 | 16篇 |
1997年 | 17篇 |
1996年 | 15篇 |
1995年 | 14篇 |
1994年 | 12篇 |
1993年 | 12篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 11篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 7篇 |
1985年 | 9篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1981年 | 8篇 |
1980年 | 4篇 |
1978年 | 3篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1973年 | 3篇 |
排序方式: 共有1263条查询结果,搜索用时 15 毫秒
111.
112.
Saijo R Tsunekawa S Murakami H Shirai N Ikeda S Odashima K 《Bioorganic & medicinal chemistry letters》2007,17(3):767-771
New ditopic sensory elements 2 and 3 for catecholamines based on a hexahomotrioxacalix[3]arene, with a boronic acid substituent appended, were designed and synthesized. As an interesting mode of molecular recognition at membrane surfaces, the host, when incorporated into poly(vinyl chloride) (PVC) liquid membranes, displayed excellent potentiometric selectivity for dopamine over other catecholamines (noradrenaline and adrenaline) and inorganic cations (Na+, K+, and NH4+). 相似文献
113.
Ichinohe T Kawaguchi A Tamura S Takahashi H Sawa H Ninomiya A Imai M Itamura S Odagiri T Tashiro M Chiba J Sata T Kurata T Hasegawa H 《Microbes and infection / Institut Pasteur》2007,9(11):1333-1340
The avian H5N1 influenza virus has the potential to cause a new pandemic. Since it is difficult to predict which strain of influenza will cause a pandemic, it is advantageous to produce vaccines that confer cross-protective immunity. Mucosal vaccine administration was reported to induce cross-protective immunity by inducing secretion of IgA at the mucosal surface. Adjuvants can also enhance the development of fully protective mucosal immunity. Here we show that a new mucosal adjuvant, poly I:poly C12U (Ampligen), a Toll-like receptor 3 agonist proven to be safe in a Phase III human trial, is an effective adjuvant for H5N1 influenza vaccination. Intranasal administration of a candidate influenza vaccine with Ampligen resulted in secretion of IgA, and protected mice that were subsequently challenged with homologous A/Vietnam/1194/2004 and heterologous A/HK/483/97 and A/Indonesia/6/2005 virus. 相似文献
114.
115.
Takahashi A Miyoshi S Takata N Nakano M Hamamoto A Mawatari K Harada N Shinoda S Nakaya Y 《Cellular microbiology》2007,9(3):583-595
Haemolysin (VMH) is a virulent factor produced by Vibrio mimicus, a human pathogen that causes diarrhoea. As intestinal epithelial cells are the primary targets of haemolysin, we investigated its effects on ion transport in human colonic epithelial Caco-2 cells. VMH increased the cellular short circuit current (Isc), used to estimated ion fluxes, and 125I efflux of the cells. The VMH-induced increases in Isc and 125I efflux were suppressed by depleting Ca2+ from the medium or by pretreating the cells with BAPTA-AM or by Rp-adenosin 3',5'-cyclic monophosphorothioate triethylammonium salt (Rp-cAMPS). The Cl- channel inhibitors 4,4'-disothiocyanatostibene-2,2'-disulfonic acid (DIDS), glybenclamide, and 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) suppressed the VMH-induced increases in Isc and 125I efflux. Moreover, VMH increased the intracellular concentrations of Ca2+ and cAMP. Thus, VMH stimulates Caco-2 cells to secrete Cl- by activating both Ca2+ -dependent and cAMP-dependent Cl- secretion mechanisms. VMH forms ion-permeable pores in the lipid bilayer that are non-selectively permeable to small ions. However, the ion permeability of these pores was not inhibited by glybenclamide and DIDS, and VMH did not change the cell membrane potential. These observations indicate that the pores formed on the cell membrane by VMH are unlikely to be involved in VMH-induced Cl- secretion. Notably, VMH stimulated fluid accumulation in the iliac loop test that was fully suppressed by a combination of DIDS and glybenclamide. Thus, Ca2+-dependent and cAMP-dependent Cl- secretion may be important therapeutic targets with regard to the diarrhoea that is induced by Vibrio mimicus. 相似文献
116.
Takahashi Miyuki Takasugi Toshiyuki Kawakami Arisa Wei Ran Ando Kanae Ohshima Toshio Hisanaga Shin-ichi 《Neurochemical research》2022,47(9):2773-2779
Neurochemical Research - Valproic acid (VPA) is a drug used for the treatment of epilepsy, seizures, migraines, and bipolar disorders. Cyclin-dependent kinase 5 (Cdk5) is a Ser/Thr kinase activated... 相似文献
117.
Kusui Yuka Izuo Naotaka Uno Kyosuke Ge Bin Muramatsu Shin-ichi Nitta Atsumi 《Neurochemical research》2022,47(9):2856-2864
Neurochemical Research - Methamphetamine (METH), the most widely distributed psychostimulant, aberrantly activates the reward system in the brain to induce addictive behaviors. The presynaptic... 相似文献
118.
119.
120.