全文获取类型
收费全文 | 39006篇 |
免费 | 2994篇 |
国内免费 | 2908篇 |
专业分类
44908篇 |
出版年
2024年 | 97篇 |
2023年 | 517篇 |
2022年 | 1176篇 |
2021年 | 2155篇 |
2020年 | 1360篇 |
2019年 | 1717篇 |
2018年 | 1729篇 |
2017年 | 1177篇 |
2016年 | 1645篇 |
2015年 | 2400篇 |
2014年 | 2828篇 |
2013年 | 3074篇 |
2012年 | 3577篇 |
2011年 | 3167篇 |
2010年 | 1988篇 |
2009年 | 1618篇 |
2008年 | 1970篇 |
2007年 | 1719篇 |
2006年 | 1587篇 |
2005年 | 1287篇 |
2004年 | 1053篇 |
2003年 | 910篇 |
2002年 | 763篇 |
2001年 | 668篇 |
2000年 | 588篇 |
1999年 | 629篇 |
1998年 | 351篇 |
1997年 | 364篇 |
1996年 | 344篇 |
1995年 | 316篇 |
1994年 | 332篇 |
1993年 | 263篇 |
1992年 | 312篇 |
1991年 | 242篇 |
1990年 | 213篇 |
1989年 | 189篇 |
1988年 | 127篇 |
1987年 | 101篇 |
1986年 | 92篇 |
1985年 | 86篇 |
1984年 | 59篇 |
1983年 | 53篇 |
1982年 | 34篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1979年 | 11篇 |
1976年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
101.
102.
103.
104.
Marino R Thuraisingam T Camateros P Kanagaratham C Xu YZ Henri J Yang J He G Ding A Radzioch D 《Journal of immunology (Baltimore, Md. : 1950)》2011,186(7):4433-4442
Secretory leukocyte protease inhibitor (SLPI) is an anti-inflammatory protein that is observed at high levels in asthma patients. Resiquimod, a TLR7/8 ligand, is protective against acute and chronic asthma, and it increases SLPI expression of macrophages in vitro. However, the protective role played by SLPI and the interactions between the SLPI and resiquimod pathways in the immune response occurring in allergic asthma have not been fully elucidated. To evaluate the role of SLPI in the development of asthma phenotypes and the effect of resiquimod treatment on SLPI, we assessed airway resistance and inflammatory parameters in the lungs of OVA-induced asthmatic SLPI transgenic and knockout mice and in mice treated with resiquimod. Compared with wild-type mice, allergic SLPI transgenic mice showed a decrease in lung resistance (p < 0.001), airway eosinophilia (p < 0.001), goblet cell hyperplasia (p < 0.001), and plasma IgE levels (p < 0.001). Allergic SLPI knockout mice displayed phenotype changes significantly more severe compared with wild-type mice. These phenotypes included lung resistance (p < 0.001), airway eosinophilia (p < 0.001), goblet cell hyperplasia (p < 0.001), cytokine levels in the lungs (p < 0.05), and plasma IgE levels (p < 0.001). Treatment of asthmatic transgenic mice with resiquimod increased the expression of SLPI and decreased inflammation in the lungs; resiquimod treatment was still effective in asthmatic SLPI knockout mice. Taken together, our study showed that the expression of SLPI protects against allergic asthma phenotypes, and treatment by resiquimod is independent of SLPI expression, displayed through the use of transgenic and knockout SLPI mice. 相似文献
105.
106.
The RhoA/ROCK-2 signaling pathway is necessary for activated hepatic stellate cell (HSC) contraction. HSC contraction plays an important role in the pathogenesis of cirrhosis and portal hypertension. This study investigated whether aldosterone contributes to HSC contraction by activation of the RhoA/ROCK-2 signaling pathway. Primary HSCs were isolated from Sprague-Dawley rats via in situ pronase/collagenase perfusion. We found that aldosterone enhanced the contraction of a collagen lattice seeded with HSCs. This induced contraction was suppressed by the mineralcorticoid receptor (MR) inhibitor spironolactone, the ROCK-2 inhibitor Y27632, and the angiotensin II type 1 receptor (AT(1)R) inhibitor irbesartan. Moreover, actin fiber staining showed that aldosterone significantly increased actin fiber formation in HSCs. Pre-incubating with spironolactone, Y27632, or irbesartan inhibited the aldosterone-induced actin fiber reorganization. Molecularly, the effect of aldosterone on activation of HSC contraction was mediated by phosphorylated myosin light chain (P-MLC) through the RhoA/ROCK-2 signaling pathway. All these inhibitors had the ability to block aldosterone-induced protein expressions in the RhoA/ROCK-2/P-MLC cascade in HSCs. Taken together, our current study suggests that aldosterone induces contraction of activated HSCs through the activation of the RhoA/ROCK-2 signaling pathway. This finding may provide a potential therapeutic target for control of cirrhosis and portal hypertension. 相似文献
107.
在自行建立的人工海洋小生境中,采用示踪法综合地研究~(137)Cs、~(134)Cs在人工小生境中的行为。结果表明,~(137)Cs和~(134)Cs具有共同的生理生态行为,并表现出相似的规律、沉积物对~(137)Cs、~(134)Cs的吸附能力甚低,~(137)Cs、~(134)Cs在海洋动物体内趋于全身性的分布。各主要生化物质均能检出~(137)Cs、~(134)Cs。排泄实验后,海洋动物的胃肠、肝(消化腺)~(137)Cs、~(134)Cs损失显著。沉积物表现为解吸-重吸附的过程。 相似文献
108.
109.
110.