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91.
Shigeko Kijimoto-Ochiai Naoko Doi Hiroko Matsukawa Miwako Fujii Koji Tomobe 《Glycoconjugate journal》2003,20(6):375-384
We have sought an endogenous membrane bound sialidase acting at neutral pH in immune system, because the removal of sialic
acid from cell surfaces will affect the cell-cell interaction directly or indirectly. The levels of activity of unique membrane-bound
sialidase at neutral pH and also soluble sialidase are high in the thymus but low in the spleen and lymph nodes. These are
thought to be plasma membrane and cytosolic types based on the behavior of inhibition by Cu2+ and 2-deoxy-2, 3-dehydro-N-acetylneuraminic acid. Newly synthesized 5-bromo-4-chloro-3-indolyl-N-acetylnueraminic acid was
used for histochemical staining of sialidase-positive thymic cells, and the results showed positive cells sparsely distributed
in the corticomedullar region or medullary region of the thymus. They expressed immunoglobulin and Mac-1 antigen on their
surfaces. These cells must therefore be of a B cell lineage, not a T cell lineage. We also found that some vessels in the
thymus were sialidase-positive. Published in 2004.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
92.
Yota Mizuno Mayu Suzuki Hiroki Nakagawa Nana Ninagawa Shigeko Torihashi 《Histochemistry and cell biology》2009,132(6):669-672
Among six actin isoforms, α-skeletal and α-cardiac actins have similar amino acid components and are highly conserved. Although
skeletal muscles essentially express α-skeletal actins in the adult tissue, α-cardiac isoform actin is prominent in the embryonic
muscle tissue. Switching of actin isoforms from α-cardiac to α-skeletal actin occurs during skeletal muscle differentiation.
The cardiac type α-actin is expressed in the regeneration and patho-physiological states of the skeletal muscles as well.
In the present study, we demonstrate the morphological switching of α-type actin isoforms from α-cardiac to α-skeletal actin
in vitro using mouse ES cells for the first time. Immunofluorescent double staining with two specific antibodies revealed
that α-cardiac actin appeared first in myoblasts. After cell fusion to form myotubes, the cardiac type actin decreased and
α-skeletal actin conversely increased. Finally, the α-skeletal isoform remained as a main actin component in the fully mature
skeletal muscle fibers. The exchange of isoforms is not directly linked to the sarcomere formation. As a result, ES cells
provide a useful in vitro system for exploring skeletal muscle differentiation. 相似文献
93.
Shigeko Kijimoto-Ochiai Akira Makita Almuth Bünsch Hans Paulsen 《Biochimica et Biophysica Acta (BBA)/General Subjects》1983,756(2):247-249
The Forssman antigenicity of a chemically synthesized globopentaose was studied. Globobentaose at 40 ng showed strong inhibitory activity for the formation of a precipitin line between globopentaosylceramide (Forssman glycolipid) and anit-Forssmann rabbit antiserum, while much more pentasaccharide (7 and 100 μg, respectively) was required to inhibit a 50% quantitative precipitin reaction and a hemolysis reaction. An immune complex of the 3H-labeled globopentaose with anti-Forssman antibody was hardly formed. Thus, the chemically synthesized globopentaose possesses the same antigenic specificity as globopentaosylceramide but it is difficult to achieve a stable complex with Forssman antibody. 相似文献