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991.
Hirokazu Ueno Makoto Kawai Hirohisa Shimokawa Masako Hirota Masashi Ohmi Rie Sudo Atsuko Ohta Yoshimasa Arano Kazunari Hattori Takashi Ohmi Naoto Kato Midori Kojima Yoshinobu Ueno Mitsuko Yamamoto Yukiko Moriguchi Hiroyuki Eda Kazunao Masubuchi 《Bioorganic & medicinal chemistry letters》2009,19(1):199-202
The P4 region of a series of oxamyl dipeptide caspase inhibitors was optimized by the combination of anti-apoptotic activity in the Jurkat/Fas (JFas) cellular assay and membrane permeability in the PAMPA assay. Two highly potent anti-apoptotic agents with moderate membrane permeability, 29 and 36, showed strong in vivo efficacy in a murine model of α-Fas-induced liver injury. 相似文献
992.
Isotope effects of deuterium on photosynthetic metabolism ofcarbon in Chlorella ellipsoidea were investigated. Photosyntheticfixation of 14C in D2O was about a half of that in H2O. Eachstep in the photosynthetic metabolism of carbon was affecteddifferently by D2O in the medium and constitutive D. (Received June 15, 1989; Accepted October 23, 1989) 相似文献
993.
994.
Two-component lipid bilayers of dipalmitoylphosphatidylcholine and dimyristoylphosphatidylcholine were studied by measuring, ultrasonic velocity and absorption at 3 MHz. The phase diagram of the two-component lipid bilayers is discussed based upon the transition anomalies of the ultrasonic velocity as well as absorption, and it is suggested that this binary system has two critical points. The bulk modulus of lipid bilayers was determined from the ultrasonic velocity to be (2.2–3.0) × 1010, whereas the bulk viscosity calculated from the absorption was 10–20 P except for the transition regions. 相似文献
995.
Shinichi Nishimura Kumiko Ishii Kunihiko Iwamoto Yuko Arita Shigeki Matsunaga Yoshiko Ohno-Iwashita Satoshi B. Sato Hideaki Kakeya Toshihide Kobayashi Minoru Yoshida 《PloS one》2013,8(12)
Cholesterol plays important roles in biological membranes. The cellular location where cholesterol molecules work is prerequisite information for understanding their dynamic action. Bioimaging probes for cholesterol molecules would be the most powerful means for unraveling the complex nature of lipid membranes. However, only a limited number of chemical or protein probes have been developed so far for cytological analysis. Here we show that fluorescently-labeled derivatives of theonellamides act as new sterol probes in mammalian cultured cells. The fluorescent probes recognized cholesterol molecules and bound to liposomes in a cholesterol-concentration dependent manner. The probes showed patchy distribution in the plasma membrane, while they stained specific organelle in the cytoplasm. These data suggest that fTNMs will be valuable sterol probes for studies on the role of sterols in the biological membrane under a variety of experimental conditions. 相似文献
996.
997.
998.
Hyoseung Shin Hyeon Gyeong Yoo Shigeki Inui Satoshi Itami In Gyu Kim A-Ri Cho Dong Hun Lee Won Seok Park Ohsang Kwon Kwang Hyun Cho Chong Hyun Won 《BMB reports》2013,46(9):460-464
The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-β1 secretion is increased by androgen treatment in DP-6, whereas androgeninducible TGF-β1 was significantly suppressed by the ROSscavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-β1 by androgen is mediated by ROS in hair follicle DPCs. [BMB Reports 2013; 46(9): 460-464] 相似文献
999.
1000.
Masashi Maekawa Shigeki Higashiyama 《BioEssays : news and reviews in molecular, cellular and developmental biology》2020,42(8):1900256
Protein ubiquitination constitutes a post-translational modification mediated by ubiquitin ligases whereby ubiquitinated substrates are degraded through the proteasomal or lysosomal pathways, or acquire novel molecular functions according to their “ubiquitin codes.” Dysfunction of the ubiquitination process in cells causes various diseases such as cancers along with neurodegenerative, auto-immune/inflammatory, and metabolic diseases. KCTD10 functions as a substrate recognition receptor for cullin-3 (CUL3), a scaffold protein in RING-type ubiquitin ligase complexes. Recently, studies by ourselves and others have identified new substrates that are ubiquitinated by the CUL3/KCTD10 ubiquitin ligase complex. Moreover, the type of polyubiquitination (e.g., K27-, K48-, or K63-chain) of various substrates (e.g., RhoB, CEP97, EIF3D, and TRIF) mediated by KCTD10 underlies its divergent roles in endothelial barrier formation, primary cilium formation, plasma membrane dynamics, cell proliferation, and immune response. Here, the physiological functions of KCTD10 are summarized and potential mechanisms are proposed. 相似文献