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Wang SW Parhar K Chiu KJ Tran A Gangoiti P Kong J Gonzalez M Salh B Duronio V Steinbrecher UP Gómez-Muñoz A 《Cellular signalling》2007,19(8):1772-1783
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Ho Kuo-Hao Chen Peng-Hsu Shih Chwen-Ming Lee Yi-Ting Cheng Chia-Hsiung Liu Ann-Jeng Lee Chin-Cheng Chen Ku-Chung 《Cellular and molecular neurobiology》2022,42(3):791-806
Cellular and Molecular Neurobiology - The insulin-like growth factor (IGF)-1 and transforming growth factor (TGF)-β signal pathways are both recognized as important in regulating cancer... 相似文献
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Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3
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168.
Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world mice 总被引:2,自引:0,他引:2
Song Y Endepols S Klemann N Richter D Matuschka FR Shih CH Nachman MW Kohn MH 《Current biology : CB》2011,21(15):1296-1301
Polymorphisms in the vitamin K 2,3-epoxide reductase subcomponent 1 (vkorc1) of house mice (Mus musculus domesticus) can cause resistance to anticoagulant rodenticides such as warfarin [1-3]. Here we show that resistant house mice can also originate from selection on vkorc1 polymorphisms acquired from the Algerian mouse (M. spretus) through introgressive hybridization. We report on a polymorphic introgressed genomic region in European M. m. domesticus that stems from M. spretus, spans >10 Mb on chromosome 7, and includes the molecular target of anticoagulants vkorc1 [1-4]. We show that in the laboratory, the homozygous complete vkorc1 allele of M. spretus confers resistance when introgressed into M. m. domesticus. Consistent with selection on the introgressed allele after the introduction of rodenticides in the 1950s, we found signatures of selection in patterns of variation in M. m. domesticus. Furthermore, we detected adaptive protein evolution of vkorc1 in M. spretus (Ka/Ks = 1.54-1.93) resulting in radical amino acid substitutions that apparently cause anticoagulant tolerance in M. spretus as a pleiotropic effect. Thus, positive selection produced an adaptive, divergent, and pleiotropic vkorc1 allele in the donor species, M. spretus, which crossed a species barrier and produced an adaptive polymorphic trait in the recipient species, M. m. domesticus. 相似文献
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Chu LJ Yang H Shih P Kao Y Tsai YS Chen J Huang G Weng RR Ting YS Fang X von Haller PD Goodlett DR Ng WV 《Journal of proteome research》2011,10(7):3261-3273
The 1310 Haloarcula marismortui proteins identified from mid-log and late-log phase soluble and membrane proteomes were analyzed in metabolic and cellular process networks to predict the available systems and systems fluctuations upon environmental stresses. When the connected metabolic reactions with identified proteins were examined, the availability of a number of metabolic pathways and a highly connected amino acid metabolic network were revealed. Quantitative spectral count analyses suggested 300 or more proteins might have expression changes in late-log phase. Among these, integrative network analyses indicated approximately 106 were metabolic proteins that might have growth-phase dependent changes. Interestingly, a large proportion of proteins in affected biomodules had the same trend of changes in spectral counts. Disregard the magnitude of changes, we had successfully predicted and validated the expression changes of nine genes including the rimK, gltCP, rrnAC0132, and argC in lysine biosynthesis pathway which were downregulated in late-log phase. This study had not only revealed the expressed proteins but also the availability of biological systems in two growth phases, systems level changes in response to the stresses in late-log phase, cellular locations of identified proteins, and the likely regulated genes to facilitate further analyses in the postgenomic era. 相似文献
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