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41.
A recent literature review of commentaries and ‘state of the art’ articles from researchers in psychiatric genetics (PMG)
offers a consensus about progress in the science of genetics, disappointments in the discovery of new and effective treatments,
and a general optimism about the future of the field. I argue that optimism for the field of psychiatric molecular genetics
(PMG) is overwrought, and consider progress in the field in reference to a sample estimate of US National Institute of Mental
Health funding for this paradigm for the years 2008 and 2009. I conclude that the amounts of financial investment in PMG is
questionable from an ethical perspective, given other research and clinical needs in the USA. 相似文献
42.
The forty-two days long experiment was conducted on a total of 1000 Arbor Acres broilers, divided into two groups. Both groups
of broilers were fed with a commercial feed mixture which consisted of standard feedstuffs and contained enough nutrients
regarding the requirements. During the first three weeks of the trial, corn naturally contaminated with AFB1 0.0445 ppm per kg dry matter was used in the amount of 20% in the experimental group, while AFB1 free corn was given to birds in the control group. After the period of toxin administration until the end of the trial, broilers
from both groups were normally fed another 5 weeks with uncontaminated feed.
In the first phase of the trial, broilers in the control groups had an average daily gain (ADG) of 31 g, average daily feed
intake (ADFI) of 45 g and a feed: gain ratio (FCR) of 1.42. In the same time, experimental broilers achieved an ADG of 25
g, ADFI of 35 g and a FCR of 1.39. During the whole period of the trial, control and experimental broilers achieved 49.12
g, 95.24 g and 1.94 and 39.71 g, 86.90 g and 2.19, respectively. 相似文献
43.
Spencer G. Lucas Bolat U. Bayshashov Lyubov A. Tyutkova Ayzhan K. Zhamangara Bolat Z. Aubekerov 《Pal?ontologische Zeitschrift》1997,71(3-4):305-314
At Aktau Mountain in the Ili depression of eastern Kazakstan, fossil mammals that encompass the Paleogene-Neogene boundary occur at three stratigraphic levels. The lowest level is in the lower Kyzylbulak Formation and produces Brontotheriidae and the hyracodontidArdynia and is tentatively assigned a late Eocene (Ergilian) age. The lower part of the overlying Aktau Formation produces fossils of the giant rhinocerosParaceratherium and is tentatively assigned a late Oligocene (Tabenbulukian) age. The upper part of the Aktau Formation yields a fossil mammal assemblage that includesGomphotherium,Stephanocemas, Brachypotherium andLagomeryx. It is clearly of Miocene age, probably late early Miocene (late Burdigalian), a correlative of European Reference Level MN 5 and the late Shanwangian of China. The Paleogene-Neogene boundary at Aktau Mountain thus is in the Aktau Formation. 相似文献
44.
Xiaozhong Huang Yujuan Shi Hongjin Chen Rongrong Le Xiaohua Gong Ke Xu Qihan Zhu Feixia Shen Zimiao Chen Xuemei Gu Xiaojun Chen Xiong Chen 《Cell death & disease》2020,11(12)
Diabetic nephropathy (DN) as a global health concern is closely related to inflammation and oxidation. Isoliquiritigenin (ISL), a natural flavonoid compound, has been demonstrated to inhibit inflammation in macrophages. Herein, we investigated the effect of ISL in protecting against the injury in STZ-induced type 1 DN and in high glucose-induced NRK-52E cells. In this study, it was revealed that the administration of ISL not only ameliorated renal fibrosis and apoptosis, but also induced the deterioration of renal function in diabetic mice. Mediated by MAPKs and Nrf-2 signaling pathways, respectively, upstream inflammatory response and oxidative stress were neutralized by ISL in vitro and in vivo. Moreover, as further revealed by the results of molecular docking, sirtuin 1 (SIRT1) binds to ISL directly, and the involvement of SIRT1 in ISL-mediated renoprotective effects was confirmed by studies using in vitro models of SIRT1 overexpression and knockdown. In summary, by reducing inflammation and oxidative stress, ISL has a significant pharmacological effect on the deterioration of DN. The benefits of ISL are associated with the direct binding to SIRT1, the inhibition of MAPK activation, and the induction of Nrf-2 signaling, suggesting the potential of ISL for DN treatment.Subject terms: Pharmacology, Molecular biology 相似文献
45.
46.
A Sólyom S Tóth I Holczinger J Vajda Z Tóth R Kálmánchey 《Applied neurophysiology》1985,48(1-6):222-225
Four thalamic and cortical recordings were carried out in 5 patients. The thalamic-evoked potentials were typical and revealed a triphasic complex, but their latencies showed a relatively high standard deviation. They could be divided into two groups according to their latencies, both of which had low SD. These data suggested that there could be two types of latency of thalamic SEP, because the 4 patients' body sizes were very similar. More detailed surface, cortical and depth recordings are needed to resolve these questions. 相似文献
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49.
Tsyganov V. E.; Pavlova Z. B.; Kravchenko L. V.; Rozov S. M.; Borisov A. Y.; Lutova L. A.; Tikhonovich I. A. 《Annals of botany》2000,86(5):975-981
Using ethyl methane sulfonate (EMS) treatment of the seeds ofline SGE, a new mutant of pea (Pisum sativum L.) with alterationsin root development was obtained. The mutant phenotype dependson the density of the growth substrate: on sand (a high densitysubstrate) the mutant forms a small compact curly root systemwhereas on vermiculite (a low density substrate) differencesbetween the root systems of the mutant and wild type plantsare less pronounced. Genetic analysis revealed that the mutantcarries a mutation in a new pea gene designedcrt (curly roots).Gene crt has been localized in pea linkage group V. The mutantline named SGEcrt showed increased sensitivity to exogenousauxin and an increased concentration of endogenous indole-3-aceticacid (IAA) in comparison with the wild type line SGE. Copyright2000 Annals of Botany Company Pisum sativum L., root development, garden pea mutant, curly roots, auxin, environmental stimulus response 相似文献
50.
Effect of precursors on biosynthesis of monensins A and B 总被引:1,自引:0,他引:1
Precursors of monensins (acetate, propionate, butyrate, isobutyrate) affect the total production and the relative proportion of monensins A and B. Addition of propionate into the fermentation medium causes a prevalence of monensin B whereas butyrate and isobutyrate stimulate the production of monensin A and suppress the production of monensin B. 相似文献