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Wu S Fluxe A Janusz JM Sheffer JB Browning G Blass B Cobum K Hedges R Murawsky M Fang B Fadayel GM Hare M Djandjighian L 《Bioorganic & medicinal chemistry letters》2006,16(22):5859-5863
A novel class of tetrahydroindolone-derived semicarbazones has been discovered as potent Kv1.5 blockers. In in vitro studies, several compounds exhibited very good potency for blockade of Kv1.5. Compound 8i showed good selectivity for blockade of Kv1.5 vs hERG and L-type calcium channels. In an anesthetized pig model, compounds 8i and 10c increased atrial ERP about 28%, 18%, respectively, in the right atrium without affecting ventricular ERP. 相似文献
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Siji Li Ming Kuang Luoying Chen Yunfei Li Shengde Liu Hongqiang Du Lili Cao Fuping You 《Cell reports》2021,34(3):108631
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