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991.
Costford SR Chaudhry SN Crawford SA Salkhordeh M Harper ME 《American journal of physiology. Endocrinology and metabolism》2008,295(5):E1018-E1024
Uncoupling protein-3 (UCP3) is a mitochondrial inner-membrane protein highly expressed in skeletal muscle. While UCP3's function is still unknown, it has been hypothesized to act as a fatty acid (FA) anion exporter, protecting mitochondria against lipid peroxidation and/or facilitating FA oxidation. The aim of this study was to determine the effects of long-term feeding of a 45% fat diet on whole body indicators of muscle metabolism in congenic C57BL/6 mice that were either lacking UCP3 (Ucp3(-/-)) or had a transgenically induced approximately twofold increase in UCP3 levels (UCP3tg). Mice were fed the high-fat (HF) diet for a period of either 4 or 8 mo immediately following weaning. After long-term HF feeding, UCP3tg mice weighed an average of 15% less than wild-type mice (P < 0.05) and were 20% less metabolically efficient than both wild-type and Ucp3(-/-) mice (P < 0.01). Additionally, wild-type mice had 21% lower, whereas UCP3tg mice had 36% lower, levels of adiposity compared with Ucp3(-/-) mice (P < 0.05 and P < 0.001, respectively), indicating a protective effect of UCP3 against fat gain. No differences in whole body oxygen consumption were detected following long-term HF feeding. Glucose and insulin tolerance tests revealed that both the UCP3tg and Ucp3(-/-) mice were more glucose tolerant and insulin sensitive compared with wild-type mice after short-term HF feeding, but this protection was not maintained in the long term. Findings indicate that UCP3 is involved in protection from fat gain induced by long-term HF feeding, but not in protection from insulin resistance. 相似文献
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995.
Large herbivores influence the composition and diversity of shrub-steppe communities in the Rocky Mountains, USA 总被引:2,自引:0,他引:2
It is widely believed that wild and domestic herbivores have modified the structure and composition of arid and semi-arid
plant communities of western North America, but these beliefs have rarely been tested in long-term, well-replicated studies.
We examined the effects of removing large herbivores from semi-arid shrublands for 40–50 years using 17 fenced exclosures
in western Colorado, USA. Shrub cover was greater (F=5.87, P=0.0020) and cover (F=3.01, P=0.0601) and frequency (F=3.89, P=0.0211) of forbs was less inside the exclosures (protected) relative to grazed plots. However, we found no significant effects
(minimum P=0.18) of protection from grazing on cover or frequency of grasses, biotic crusts, or bare soil. Although mean species richness
and diversity were similar between treatments, protected areas had much higher dominance by fewer species, primarily sagebrush.
Exclusion of herbivores changed the relationship between species richness and evenness. Consistent with theoretical expectations,
species evenness was positively correlated with richness in protected plots (r
2=0.54). However, contrary to theory, evenness and richness were inversely related in grazed plots (r
2
adjacent=0.72, r
2
distant=0.84). We suggest that these differences resulted because grazing acts as a stressor promoting facilitative relationships
between plant species that might compete for resources in the absence of grazing. We conclude that exclusion of grazing in
the sites we studied caused minor changes in cover and diversity of herbaceous plants, but caused a clear increase in the
cover of shrubs. Importantly, the exclusion of ungulates changed the relationship between evenness and richness. 相似文献
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997.
The prevalence of agglutinating antibodies to Toxoplasma gondii was examined in striped skunks (Mephitis mephitis), opossums (Didelphis virginiana), and raccoons (Procyon lotor) from 8 cities in Connecticut. Ten (42%) of the 24 striped skunks, 2 of 7 (29%) opossums, and 12 of 12 (100%) raccoons were positive at dilutions of 1:50 or greater. These results suggest that T. gondii is prevalent in the environment, or prey items, or both, of these omnivores in Connecticut. 相似文献
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999.
One of the crucial steps of authentication of aDNA sequences is phylogenetic consistency. Amplified sequences should fit into the phylogenetic framework of their supposed origin. An inherent property of aDNA sequences however, is their short sequence length. Additionally, genes for aDNA studies are often chosen by their preservation potential rather than by phylogenetically informative content. This poses potential challenges regarding their analyses, and might result in an inaccurate reflection of the supposed phylogenetic history of the sequence or organism under study. In this paper some fundamental problems of phylogenetic analysis and interpretation of aDNA datasets are discussed. Suggestions for character sampling and treatment of missing data are made. The publication is the result of a talk from the 1st PAMINSA Meeting in Rio de Janeiro, July 2005. 相似文献