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101.
Roberto E. Flores Ashley K. Brown Luke Taus Julianna Khoury Frank Glover Kenjiro Kami Rangaprasad Sarangarajan Tony E. Walshe Niven R. Narain Michael A. Kiebish Laura M. Shelton Christos Chinopoulos Thomas N. Seyfried 《BBA》2018,1859(9):975-983
Succinate is known to act as an inflammatory signal in classically activated macrophages through stabilization of HIF-1α leading to IL-1β production. Relevant to this, hypoxia is known to drive succinate accumulation and release into the extracellular milieu. The metabolic alterations associated with succinate release during inflammation and under hypoxia are poorly understood. Data are presented showing that Mycoplasma arginini infection of VM-M3 cancer cells enhances the Warburg effect associated with succinate production in mitochondria and eventual release into the extracellular milieu. We investigated how succinate production and release was related to the changes of other soluble metabolites, including itaconate and 2-HG. Furthermore, we found that hypoxia alone could induce succinate release from the VM-M3 cells and that this could occur in the absence of glucose-driven lactate production. Our results elucidate metabolic pathways responsible for succinate accumulation and release in cancer cells, thus identifying potential targets involved in both inflammation and hypoxia. This article is part of a Special Issue entitled 20th European Bioenergetics Conference, edited by László Zimányi and László Tretter. 相似文献
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103.
Kelsey H. Fisher-Wellman James A. Draper Michael T. Davidson Ashley S. Williams Tara M. Narowski Dorothy H. Slentz Olga R. Ilkayeva Robert D. Stevens Gregory R. Wagner Rami Najjar Mathew D. Hirschey J. Will Thompson David P. Olson Daniel P. Kelly Timothy R. Koves Paul A. Grimsrud Deborah M. Muoio 《Cell reports》2019,26(6):1557-1572.e8
104.
Jelena Petrovic Yeqiao Zhou Maria Fasolino Naomi Goldman Gregory W. Schwartz Maxwell R. Mumbach Son C. Nguyen Kelly S. Rome Yogev Sela Zachary Zapataro Stephen C. Blacklow Michael J. Kruhlak Junwei Shi Jon C. Aster Eric F. Joyce Shawn C. Little Golnaz Vahedi Warren S. Pear Robert B. Faryabi 《Molecular cell》2019,73(6):1174-1190.e12
105.
Jessica A. Kendziorski Chrissy Sherrill Ashley T. Davis Kylie Kavanagh 《Journal of medical primatology》2019,48(6):367-369
Amniotic fluid was collected from pregnant female African green monkeys (n = 20). Analyses indicate microbial translocation into amniotic fluid during pregnancy is typical, and microbial load reduces across gestation. Microbial translocation does not relate to infant outcome or maternal factors. Lastly, we demonstrate that sample contamination is easily introduced and detectable. 相似文献
106.
107.
Ling Zhao L. Dillon Birdwell Ashley Wu Ruth Elliott Kristine M. Rose Judith M. Phillips Yize Li Judith Grinspan Robert H. Silverman Susan R. Weiss 《Journal of virology》2013,87(15):8408-8418
Previous studies have demonstrated that the murine coronavirus mouse hepatitis virus (MHV) nonstructural protein 2 (ns2) is a 2′,5′-phosphodiesterase that inhibits activation of the interferon-induced oligoadenylate synthetase (OAS)-RNase L pathway. Enzymatically active ns2 is required for efficient MHV replication in macrophages, as well as for the induction of hepatitis in C57BL/6 mice. In contrast, following intranasal or intracranial inoculation, efficient replication of MHV in the brain is not dependent on an enzymatically active ns2. The replication of wild-type MHV strain A59 (A59) and a mutant with an inactive phosphodiesterase (ns2-H126R) was assessed in primary hepatocytes and primary central nervous system (CNS) cell types—neurons, astrocytes, and oligodendrocytes. A59 and ns2-H126R replicated with similar kinetics in all cell types tested, except macrophages and microglia. RNase L activity, as assessed by rRNA cleavage, was induced by ns2-H126R, but not by A59, and only in macrophages and microglia. Activation of RNase L correlated with the induction of type I interferon and the consequent high levels of OAS mRNA induced in these cell types. Pretreatment of nonmyeloid cells with interferon restricted A59 and ns2-H126R to the same extent and failed to activate RNase L following infection, despite induction of OAS expression. However, rRNA degradation was induced by treatment of astrocytes or oligodendrocytes with poly(I·C). Thus, RNase L activation during MHV infection is cell type specific and correlates with relatively high levels of expression of OAS genes, which are necessary but not sufficient for induction of an effective RNase L antiviral response. 相似文献
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109.
Three species of lepidopterous larvae were collected fromAmaranthus hybridus L. growing in field corn during 1975 and 1976 at Hastings, Florida.Spodoptera exigua (Hubner) was the predominant species in May.Spodoptera eridania (Cramer) was predominant in June andHerpetogramma bipunctalis (F.) in July and August. Nine native species of parasites, representing theBraconidae, Eulophidae, Ichneumonidae andTachinidae, emerged from these larvae.Meteorus autographae Muesebeck emerged from bothS. exigua andS. eridania. TheTachinidae, Winthemia rufopicta (Bigot),Eucelatori rubentis (Coquillett) andLespensia sp., emerged from mixtures ofS. exigua andS. eridania. Apanteles marginiventris (Cresson),Temelucha sp., andChelonus texanus Cresson emerged from bothS. exigua andH. bipunctalis larvae, andEuplectrus platyhypenae Howard andOphion sp. emerged fromS. eridania. All the species of parasites from the lepidopterous larvae that feed onAmaranthus hybridus are also reported as parasites ofS. frugiperda, a serious pest of corn. Therefore these larvae onA. hybridus may be a source of the parasites found attackingS. frugiperda. 相似文献
110.
Genetic Fine‐Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats 下载免费PDF全文
Gregory R. Keele Jeremy W. Prokop Hong He Katie Holl John Littrell Aaron Deal Sanja Francic Leilei Cui Daniel M. Gatti Karl W. Broman Michael Tschannen Shirng‐Wern Tsaih Maie Zagloul Yunjung Kim Brittany Baur Joseph Fox Melanie Robinson Shawn Levy Michael J. Flister Richard Mott Leah C. Solberg Woods 《Obesity (Silver Spring, Md.)》2018,26(1):213-222