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71.
72.
Intissar Ezzidi Nabil Mtiraoui Mohammed Eltigani Mohmmed Ali Aqeel Al Masoudi Faisel Abu Duhier 《Journal of genetics》2018,97(5):1213-1223
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in females, and is associated with altered metabolic processes in particular insulin resistance and diabetes mellitus. PCOS shares with type-2 diabetes (T2D) a number of features, including beta cell dysfunction, impaired glucose tolerance and dyslipidaemia. Recently, genomewide association studies (GWAS) have reported a number of genes with reproducible associations and susceptibilities to T2D. To address this, we examined the association between the T2D GWAS candidate genes (CDKAL1, CDKN2B, COL8A1, HHEX, IGF2BP2, KCNJ1, KCNQ1 and SLC30A8) and PCOS in Saudi women. A case–control study, includes 162 cases and 162 controls was enrolled. Genotyping was carried out by the allelic discrimination method. Our results showed that the variants including rs792837 of COL8A1, rs61873498 of KCNQ1 and rs13266634 of SLC30A8 genes to be significantly more frequent in PCOS patients than in controls. Our results suggest that COL8A1, KCNQ1 and SLC30A8, which are previously identified through GWAS as T2D-associated genes, are associated with PCOS. 相似文献
73.
Dorit Samocha‐Bonet Dov Lichtenberg Aaron Tomer Varda Deutsch Tamar Mardi Yelena Goldin Subchi Abu‐Abeid Galina Shenkerman Hana Patshornik Itzhak Shapira Shlomo Berliner 《Obesity (Silver Spring, Md.)》2003,11(3):403-407
Objective: Previous studies have suggested that obesity enhances the inflammatory response, producing macromolecules involved in the induction and/or maintenance of increased erythrocyte aggregation. The objectives of this study were to evaluate the correlation between inflammation markers, erythrocyte adhesiveness/aggregation, and the degree of obesity and to assess phosphatidylserine expression on erythrocyte surface membrane of obese vs. nonobese individuals. Research Methods and Procedures: Erythrocyte adhesiveness/aggregation in the peripheral venous blood was evaluated by using a new biomarker, phosphatidylserine expression was assessed by means of flow cytometry, and markers of inflammation were measured in 65 subjects: 30 obese [body mass index (BMI) = 41 ± 7.7 kg/m2] and 35 nonobese (BMI = 24 ± 2.7 kg/m2) individuals. Pearson correlations and Student's t test were performed. Results: A highly significant difference was noted in the degree of erythrocyte adhesiveness/aggregation and markers of inflammation between the study groups. BMI correlated with erythrocyte adhesiveness/aggregation (r = 0.42, p = 0.001), erythrocyte sedimentation rate (r = 0.42, p = 0.001), high‐sensitive C‐reactive protein (r = 0.55, p < 10?4), fibrinogen (r = 0.37, p = 0.004), and white blood cell count (r = 0.45, p < 10?4). The degree of erythrocyte adhesiveness/aggregation correlated with erythrocyte sedimentation rate (r = 0.5, p < 10?4), high‐sensitive C‐reactive protein (r = 0.56, p < 10?4), fibrinogen (r = 0.54, p < 10?4), and white blood cell count (r = 0.32, p = 0.01). Discussion: Our results suggest that obesity‐related erythrocyte adhesiveness/aggregation is probably mediated through increased concentrations of adhesive macromolecules in the circulation and not necessarily through hyperlipidemia or phosphatidylserine exposure on erythrocyte's membrane. 相似文献
74.
The purpose of the present investigation was to increase the solubility and dissolution rate of rofecoxib by the preparation
of its solid dispersion with polyvinyl pyrrolidone K30 (PVP K30) using solvent evaporation method. Drug-polymer interactions
were investigated using differential scanning calorimetry (DSC), x-ray diffraction (XRD), and Fourier transform infrared spectroscopy
(FTIR). For the preparation of rofecoxib mouth dissolve tablets, its 1∶9 solid dispersion with PVP K30 was used with various
disintegrants and sublimable materials. In an attempt to construct a statistical model for the prediction of disintegration
time and percentage friability, a 32 randomized full and reduced factorial design was used to optimize the influence of the amounts of superdisintegrant and subliming
agent. The obtained results showed that dispersion of the drug in the polymer considerably enhanced the dissolution rate.
The drug-to-carrier ratio was the controlling factor for dissolution improvement. FTIR spectra revealed no chemical incompatibility
between the drug and PVP K30. As indicated from XRD and DSC data, rofecoxib was in the amorphous form, which explains the
better dissolution rate of the drug from its solid dispersions. Concerning the optimization study, the multiple regression
analysis revealed that an optimum concentration of camphor and a higher percentage of crospovidone are required for obtaining
rapidly disintegrating tablets. In conclusion, this investigation demonstrated the potential of experimental design in understanding
the effect of the formulation variables on the quality of mouth dissolve tablets containing solid dispersion of a hydrophobic
drug. 相似文献
75.
Kamel S. Abu Jaber 《Visual Anthropology: Published in cooperation with the Commission on Visual Anthropology》2013,26(2):166-170
This article asserts that the most important physical feature distinguishing man from all other creatures, one which allowed for and contributed to the development of the thumb and the brain, which facilitated and encouraged the development of his imagination, his ability to think abstractly and even to doubt, and made it possible for him to master all other life forms and advance so far in containing and even conquering some forces of nature is his well-developed posterior; superior to that of all other living creatures: while sitting comfortably for long periods freed his hands and vision, it also allowed him to imagine and ponder what was over the horizon. 相似文献
76.
The distribution of microorganisms in 10 samples of salted dried fish and the effects of irradiation of them were studied. The total aerobic bacteria in commercial dried fish were determined to be from 2 × 104 to 3 × 106 per gram. Mold counts were 1 × 102 to 7 × 103 per gram with a lower amount of yeasts. In spoiled dried fish, total aerobic bacteria were determined to be 4× 106 or 1 × 107 per gram with a few yeasts. Coliforms were not isolated on MacConkey agar plates from any of the samples. The predominant bacteria occurring in spoiled dried fish were Pediococcus halophilus, Vibrio costicola and Planococcus sp. More than 50% of the molds consisted of the Aspergillus niger group, whereas lower amounts of the A. flavus, A. fumigatus and A. ochraceus groups, Penicillium chrysogenum series, etc. were also isolated from many samples of dried fish. All kinds of putrefactive microorganisms were radiation sensitive, and a dose of ca. 500 krad appears to be sufficient for extension of the shelf-life of dried fish from 2 to 4 times. 相似文献
77.
Eitedal H. ELsayed M.H. EL-Shafie E.O.H. Saifelnasr A.A. Abu El-Ella 《Small Ruminant Research》2009,85(1):11-17
This research was carried out on seven Damascus goats, to study the relationship between milk production, during advancing lactation, and the changes in secretory mammary cells frequency and cellular activity. Biopsies were obtained from the mammary gland at the three stages of lactation, early, mid and late, for histological and histochemical studies. The histological structures of the mammary gland showed clear differences between lactation stages—being more developed in the early and the mid stages, compared to the late stage of lactation. The number of the alveolar secretory cells increased from the early to the mid stage of lactation by 12.9% and then was reduced at the late stage by 35.9% from that at the mid stage. The milk yield increased by 51.3% from the early to the mid stage, and then was reduced at the late stage by 71.4% from that of the mid stage. The total sectional areas of plate equal to 1.22 mm2/plate of the alveoli were the smallest during late lactation (0.36 mm2/plate) compared to that during the early and the mid stage of lactation (0.50 and 1.17 mm2/plate, respectively). Numerous loci of alkaline phosphatase enzyme (AP) were apparent on the outer surface of the alveolar secretory cells at the early and the mid stages of lactation—suggesting that this enzyme plays an important physiological role in the apical membrane of the alveolar epithelial cells during lactation. Dense protein staining of these cells as well as increased frequency of DNA expression denote great development and increased numbers of these cells at early and mid stages of lactation. This was accompanied by a high level of milk secretion reaching 939.3 ± 130 and 1421.4 ± 123.4 ml/head/day, respectively. In contrast, at the late stage of lactation, the size of alveoli was reduced and few alveoli showed weak AP activity, weak protein manifestation and the lowest frequency of DNA loci. This coincided with the reduction in milk yield (407 ml/head/day). It could be concluded that the stages of the lactation influence the cell number and activity of the mammary parenchyma. 相似文献
78.
Gui-Hua Jin Yan-Li Zhou Hong Yang Yan-Ting Hu Yong Shi Ling Li Abu N. Siddique Chang-Ning Liu An-Dan Zhu Cheng-Jun Zhang De-Zhu Li 《植物分类学报:英文版》2021,59(2):341-351
Orphan genes are genetic innovations that lack homologs in other lineages. Orphan genes can rapidly originate and become substantially functional, yet the mechanisms underlying their origins are still largely unknown in plants. Here, we investigated the origin of orphan genes in the Oryza sativa ssp. japonica “Nipponbare” genome using genome‐wide comparisons with 10 closely related Oryza species. We identified a total of 37 orphan genes in the Nipponbare genome that show short sequence lengths, elevated GC content, and absence of introns. Interestingly, half of the identified orphan genes originated by way of a distinctive mechanism that involved the generation of new coding sequences through independent and rapid divergence within the inserted transposable element. Our results provide valuable insight into genetic innovations in the model rice genome that formed on a very short timescale. 相似文献
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80.