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181.
I N Sharova N A Medvedkova A P Pekhov 《Biulleten' eksperimental'no? biologii i meditsiny》1984,97(3):317-321
The authors investigated pAP20 plasmid identified in E. coli cells isolated from man. According to the evidence obtained pAP20 plasmid determines the synthesis of alpha-hemolysin, being an F-like plasmid of the drd type. Having medium molecular size, the plasmid belongs to the inc FIV group and is partly incompatible with pAP38 plasmid which is a reference plasmid of the inc FVII group. 相似文献
182.
G N Boldyreva E V Sharova L A Zhavoronkova T A Dobrokhotova 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1992,42(3):439-449
On the basis of clinico-anatomo-electroencephalographic studies it was shown, that in early terms of cerebral trauma, at gross disturbances of the cortical functions and safety in some cases of only vital regulation, the parameters of the EEG stability or variability are of distinct information value for estimation of the functional state of patients. It was established, that changes of stability of the frequency, power, and coherent EEG characteristics correlate with different parameters of changes of the structural-functional brain organization. At this stage the greatest connection with the disease outcome reveals the EEG coherence parameters of the cortical symmetrical points reflecting the state of predominantly median formations and general brain reactions to traumatic action. In the process of restoration of disturbed neuromental functions priority prognostic significance is acquired by parameters of intrahemispheric coherence as well as by frequency-regional properties of interhemispheric asymmetry of coherence of the brain electrical processes, characterizing functional features of the lesion focus. 相似文献
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185.
This article generalizes the results of many years’ studies of the EEG of patients with tumorous lesions in the diencephalic,
brainstem, and limbic structures, which fulfill the regulatory function in ensuring integral brain activity. The specific
features of the inclusion of individual structures under investigation in the organization of the intra- and interhemispheric
relations of cortical biopotentials were demonstrated against the background of diffuse changes in the biopotentials that
reflect the systemic character of neurodynamic reorganizations when the regulatory brain structures are involved in the pathological
process. This study expands the idea of the predominant functional connection of the diencephalic structures with the right
hemisphere and brainstem structures with the left one with determination of the regional specific features of changes in the
intrahemispheric EEG coherences. The distinguishing features of intercentral relations when the limbic structures are involved
in the pathological process show similarity with the neurodynamic reorganizations in patients with lesions in both diencephalic
and (even more so) brainstem structures. Universal elements were detected in the formation of integral adaptive reactions
of the brain with lesions in its regulatory structures, which reflects their close functional interaction and makes it possible
to consider them the individual links of an integral regulatory system. The study revealed reciprocal changes in various forms
of electrical activity, which reflects reciprocation of interaction of individual regulatory structures. This is one of the
EEG equivalents of the formation of adaptive-compensatory cerebral reactions. The specificity of influence of the studied
regulatory structures are clearly seen in situations of their morphofunctional isolation observed during cerebral coma. In
these conditions, when the cortex is functionally inactive, the authors demonstrated the dynamic character of changes in interhemispheric
asymmetry, which reflects the dominance of individual links of the regulatory system playing the role of supreme regulator
of life support of the body in critical states. 相似文献
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187.
The effect of radiation on the cyclic nucleotide content of mouse brain has been studied. High radiation doses have been found to increase cGMP and to decrease cAMP content of the brain. These alterations correlate with the processes of lipid peroxidation and formation of diene conjugates and malonic dialdehyde. 相似文献
188.
189.
E E Sharova 《Arkhiv anatomii, gistologii i émbriologii》1990,98(3):52-58
By means of microanatomical methods the inferior tracheobronchial lymph nodes in 36 Wistar rats have been investigated, when the animals have been subjected to the effect of dimethylsulfate (DMS) vapors. The effect of the substance in doses 0.1 and 2.0 mg/m3 for 2 and 14 days has been studied. Comparison of relative parameters of the structural components areas and the cytological profile of the lymph nodes has been performed. DMS effects for 2 and 14 days in the maximal tolerance concentration (MTC) results in increasing area of the connective tissue stroma and the cortical substance, in comparison with the control, as well as in decreasing area of the medulla substance. At the contact with DMS for 2 days (at a corresponding MTC) certain changes of the nodular cytological profile are noted. They demonstrate that to the given time of the experiment the adaptive processes in the lymph nodes have no time to develop completely. DMS effect for 14 days in the same concentration produces an increased destruction of cellular elements and inhibits the plasmocellular reaction intensity (in comparison to the control and the experiment for 2 days). DMS maximal concentration (2.0 mg/m3) results in decreasing area of the lymphoid noduli with germinative centers. Intensity of mitotic processes decreases and autoimmune processes develop. 相似文献