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331.
332.
Snehil Dixit Irfan Ahmad Kumar Gular Refaat A. Eid Ravi Shankar Reddy Ivana Leão Ribeiro Mohammed Abohashrh Mastour Saeed Alshahrani Jaya Shanker Tedla Nitin Arun Dixit 《Saudi Journal of Biological Sciences》2021,28(3):1678-1686
ObjectivesThe primary purpose of the recent experiment was to scrutinize the dissimilarity between single and multiple exposures by electrotherapeutic modalities to determine the development of Gram-positive and Gram negative bacteria spectrum.Material and methodsBacterial strains employed in this study were Gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonae and Gram-positive bacteria such as Staphylococcus aureus, Staphylococcus saprophyticus and Streptococcus pyogenes. Fluence for Low level laser therapy (LLLT) (810 nm) was 40 J/cm2 for 80 s, for microwave (MWD) a dosage of 100-Watt with duration of 5 min and for magnetic field therapy (MT) duration of 30 min with 100% intensity was used.ResultsRepeated Measures of analysis of variances (RANOVA) for within-subject effects was used to detect a global significant change within the means at dissimilar time points. The experiments of within-subjects revealed a significant difference within groups, df of (3, 40), F value of 39.38 and a p value less than 0.001, representing a significant variation between the three groups between pre and post exposures. There was a significant variation between single exposure and multiple exposures in the experimental sample’s pre-post between the four groups with df (1, 40) f value of 2943.69 and p value less than 0.001. Scanning and Transmission electron microscopy images were also taken into account to determine the extent of damage caused to the bacterial cells surface topography in Gram negative and Gram positive spectrums.ConclusionThe study demonstrated that single high exposure with the LLLT appears to have the most emphatic effect followed by exposure by MWD and MT. 相似文献
333.
Solubilization of low-grade Indian rock phosphates and inorganic phosphates byBacillus licheniformis
Bacillus licheniformis solubilized a range of inorganic phosphates and five different Indian rock phosphates (low grade) to varying extent in broth
culture and in soil. Statistical evaluation indicated that broth cultures alone were inadequate indicators of the potential
for microbial solubilization of rock phosphates. 相似文献
334.
Graham H. Jackson Charlotte Pawlyn David A. Cairns Ruth M. de Tute Anna Hockaday Corinne Collett John R. Jones Bhuvan Kishore Mamta Garg Cathy D. Williams Kamaraj Karunanithi Jindriska Lindsay Alberto Rocci John A. Snowden Matthew W. Jenner Gordon Cook Nigel H. Russell Mark T. Drayson Walter M. Gregory Martin F. Kaiser Roger G. Owen Faith E. Davies Gareth J. Morgan the UK NCRI Haemato-oncology Clinical Studies Group 《PLoS medicine》2021,18(1)
BackgroundCarfilzomib is a second-generation irreversible proteasome inhibitor that is efficacious in the treatment of myeloma and carries less risk of peripheral neuropathy than first-generation proteasome inhibitors, making it more amenable to combination therapy.Methods and findingsThe Myeloma XI+ trial recruited patients from 88 sites across the UK between 5 December 2013 and 20 April 2016. Patients with newly diagnosed multiple myeloma eligible for transplantation were randomly assigned to receive the combination carfilzomib, lenalidomide, dexamethasone, and cyclophosphamide (KRdc) or a triplet of lenalidomide, dexamethasone, and cyclophosphamide (Rdc) or thalidomide, dexamethasone, and cyclophosphamide (Tdc). All patients were planned to receive an autologous stem cell transplantation (ASCT) prior to a randomisation between lenalidomide maintenance and observation. Eligible patients were aged over 18 years and had symptomatic myeloma. The co-primary endpoints for the study were progression-free survival (PFS) and overall survival (OS) for KRdc versus the Tdc/Rdc control group by intention to treat. PFS, response, and safety outcomes are reported following a planned interim analysis. The trial is registered (ISRCTN49407852) and has completed recruitment. In total, 1,056 patients (median age 61 years, range 33 to 75, 39.1% female) underwent induction randomisation to KRdc (n = 526) or control (Tdc/Rdc, n = 530). After a median follow-up of 34.5 months, KRdc was associated with a significantly longer PFS than the triplet control group (hazard ratio 0.63, 95% CI 0.51–0.76). The median PFS for patients receiving KRdc is not yet estimable, versus 36.2 months for the triplet control group (p < 0.001). Improved PFS was consistent across subgroups of patients including those with genetically high-risk disease. At the end of induction, the percentage of patients achieving at least a very good partial response was 82.3% in the KRdc group versus 58.9% in the control group (odds ratio 4.35, 95% CI 3.19–5.94, p < 0.001). Minimal residual disease negativity (cutoff 4 × 10−5 bone marrow leucocytes) was achieved in 55% of patients tested in the KRdc group at the end of induction, increasing to 75% of those tested after ASCT. The most common adverse events were haematological, with a low incidence of cardiac events. The trial continues to follow up patients to the co-primary endpoint of OS and for planned long-term follow-up analysis. Limitations of the study include a lack of blinding to treatment regimen and that the triplet control regimen did not include a proteasome inhibitor for all patients, which would be considered a current standard of care in many parts of the world.ConclusionsThe KRdc combination was well tolerated and was associated with both an increased percentage of patients achieving at least a very good partial response and a significant PFS benefit compared to immunomodulatory-agent-based triplet therapy.Trial registrationClinicalTrials.gov ISRCTN49407852.Graham Jackson and co-workers study a combination induction treatment including carfilzomib for patients with transplant-eligible myeloma. 相似文献
335.
Susanne Hedlund Hari Shanker Sharma Per-Ove Sjquist Jan Westman 《Journal of thermal biology》1999,24(5-6):409-414
Rats exposed to 4 h heat stress at 38°C exhibited upregulation of heat shock protein (HSP 72 kD) expression in several brain regions associated with brain edema and cell injury. Pretreatment with a new anti-oxidant compound H-290/51 (50 mg/kg, per os, 30 min before stress) significantly attenuated HSP expression, brain edema and cell injury. These results suggest that oxidative stress associated with brain edema plays important roles in HSP expression, not reported earlier. 相似文献
336.
L-alanine:4,5-dioxovalerate transaminase (EC 2.6.1.44) has been purified to homogeneity from rat liver mitochondria. Molecular weight of the native enzyme is estimated to be 230,000 +/- 3000 by gel filtration. Under denaturing condition, the dissociated enzyme has a subunit of approximately 41,000 +/- 2000, indicating the enzyme apparently is composed of six identical subunits. The enzyme is heat stable and has optimal activity at pH 6.9. Km values for L-alanine and 4,5-dioxovalerate are 3.3 X 10(-3) M and 2.8 X 10(-4) M respectively. Excess dioxovalerate inhibits the enzyme activity. Pyridoxal phosphate and dithiothreitol also inhibit the enzyme activity. 相似文献