全文获取类型
收费全文 | 342篇 |
免费 | 20篇 |
国内免费 | 3篇 |
出版年
2023年 | 6篇 |
2022年 | 4篇 |
2021年 | 9篇 |
2020年 | 6篇 |
2019年 | 16篇 |
2018年 | 12篇 |
2017年 | 13篇 |
2016年 | 12篇 |
2015年 | 20篇 |
2014年 | 22篇 |
2013年 | 17篇 |
2012年 | 20篇 |
2011年 | 24篇 |
2010年 | 14篇 |
2009年 | 19篇 |
2008年 | 17篇 |
2007年 | 13篇 |
2006年 | 16篇 |
2005年 | 15篇 |
2004年 | 12篇 |
2003年 | 11篇 |
2002年 | 5篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 1篇 |
排序方式: 共有365条查询结果,搜索用时 15 毫秒
31.
32.
33.
34.
Fariba Karimzadeh Sayed Mostafa Modarres Mousavi Tahereh Ghadiri Maryam Jafarian Mansoureh Soleimani Shahin Mohammad Sadeghi Masoud Mesgari Mohammad-Taghi Joghataei Ali Gorji 《Molecular neurobiology》2017,54(2):846-854
Modulatory function of metabotropic glutamate type 1 (mGlu1) receptors plays a crucial role in the pathophysiology of some neurological disorders, including schizophrenia and epilepsy. In this study, the expression of mGlu1α receptors in the thalamic nuclei was assessed during development of absence seizures in the WAG/Rij rats, a valid genetic animal model of absence epilepsy. In addition, the effect of pharmacological modulation of mGlu1α receptors in the laterodorsal (LD) nucleus of the thalamus on the characteristic features of bioelectrical brain activities in the WAG/Rij rats was assessed. The expression of mGlu1α receptors in the LD was assessed in four experimental groups of both WAG/Rij and Wistar rats with 2 and 6 months of age. Agonist and antagonist of mGlu1α receptors were infused in LD in the six months old WAG/Rij (epileptic) rats. The protein level of mGlu1α receptors in the thalamus of the 6-month-old WAG/Rij rats was lower than non-epileptic animals. In addition, the distribution of mGlu1α receptors in different thalamic nuclei was lower in the 6-month-old WAG/Rij compared to age-matched Wistar rats. The gene expression of mGlu1α receptor was also significantly lower in 6-month-old WAG/Rij rats in the LD compared to other animal groups. The microinjection of mGlu1α receptors agonist and antagonist in the LD reduced the duration of spike-wave discharges (SWDs) and increased the amplitude and duration of SWDs, respectively, in 6-month-old WAG/Rij rats. The alterations of mGlu1α receptors expression in the thalamus of epileptic WAG/Rij rats as well as its modulatory effects in the generation of SWDs suggest the potential of mGlu1 receptors as a therapeutic target in absence epilepsy. 相似文献
35.
Biocementation is a recently developed new branch in geotechnical engineering that deals with the application of microbiological activity to improve the engineering properties of soils. One of the most commonly adopted processes to achieve soil biocementation is through microbially induced calcite precipitation (MICP). This technique utilizes the metabolic pathways of bacteria to form calcite (CaCO3) that binds the soil particles together, leading to increased soil strength and stiffness. This paper presents a review of the use of MICP for soil improvement and discusses the treatment process including the primary components involved and major affecting factors. Envisioned applications, potential advantages and limitations of MICP for soil improvement are also presented and discussed. Finally, the primary challenges that lay ahead for the future research (i.e. treatment optimization, upscaling for in situ implementation and self-healing of biotreated soils) are briefly discussed. 相似文献
36.
Shahin Negari Jeff Sulpher Francesca Pacello Keely Ingrey Andrea Battistoni B. Craig Lee 《Biometals》2008,21(3):249-258
The Cu,Zn superoxide dismutase (Cu,ZnSOD) from Haemophilus
ducreyi is the only enzyme of this class which binds a heme molecule at its dimer interface. To explore the role of the enzyme in
this heme-obligate bacterium, a sodC mutant was created by insertional inactivation. No difference in growth rate was observed during heme limitation. In contrast,
under heme rich conditions growth of the sodC mutant was impaired compared to the wild type strain. This growth defect was abolished by supplementation of exogenous catalase.
Genetic complementation of the sodC mutant in trans demonstrated that the enzymatic property or the heme-binding activity of the protein could repair the growth
defect of the sodC mutant. These results indicate that Cu,ZnSOD protects Haemophilus ducreyi from heme toxicity. 相似文献
37.
An isoenzyme analysis was performed on 109 individuals from 11 populations of Juniperus excelsa complex collected from Iran. A total of 61 allozymes from five enzyme systems were scored. The mean numbers of bands per presumed isoenzyme, ranged from 2.07 to 3.23. The value of Euclidean distance ranged from 1.920 to 4.411. The average value of Shannon diversity index (H′) estimated for each population ranged from 0.317 in the population sampled from ‘Fasa’ to 1.053 in the population of ‘Golestan’, and the average H′ value for each enzyme system ranged from 0.031 (SOD-3) to 1.670 (PPO-1). To reveal the relationships among these populations, a cluster analysis based on Euclidean distances was performed. The results of the analysis suggest recognizing three taxa in the complex in Iran: Juniperus polycarpos subsp. polycarpos, Juniperus polycarpos subsp. turcomanica, and one cryptic species not recorded from Iran until now. Moreover, the analysis presented, does not confirm the occurrence of J. excelsa in Iran. 相似文献
38.
39.
Zahra Razaghi Moghadam Kashani Hayedeh Ahrabian Elahe Elahi Abbas Nowzari-Dalini Elnaz Saberi Ansari Sahar Asadi Shahin Mohammadi Falk Schreiber Ali Masoudi-Nejad 《BMC bioinformatics》2009,10(1):318
Background
Complex networks are studied across many fields of science and are particularly important to understand biological processes. Motifs in networks are small connected sub-graphs that occur significantly in higher frequencies than in random networks. They have recently gathered much attention as a useful concept to uncover structural design principles of complex networks. Existing algorithms for finding network motifs are extremely costly in CPU time and memory consumption and have practically restrictions on the size of motifs. 相似文献40.