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81.
Chalita Liamsanguan Shabbir H. Gheewala 《The International Journal of Life Cycle Assessment》2007,12(7):529-536
Background, Aims and Scope During the combustion of municipal solid waste (MSW), energy is produced which can be utilized to generate electricity. However,
electricity production from incineration has to be evaluated from the point view of the environmental performance. In this
study, environmental impacts of electricity production from waste incineration plant in Thailand are compared with those from
Thai conventional power plants.
Methods The evaluation is based on a life cycle perspective using life cycle assessment (LCA) as the evaluation tool. Since MSW incineration
provides two services, viz., waste management and electricity production, the conventional power production system is expanded
to include landfilling without energy recovery, which is the most commonly used waste management system in Thailand, to provide
the equivalent function of waste management.
Results The study shows that the incineration performs better than conventional power plants vis-à-vis global warming and photochemical
ozone formation, but not for acidification and nutrient enrichment.
Discussion There are some aspects which may influence this result. If landfilling with gas collection and flaring systems is included
in the analysis along with conventional power production instead of landfilling without energy recovery, the expanded system
could become more favorable than the incineration in the global warming point of view. In addition, if the installation of
deNOx process is employed in the MSW incineration process, nitrogen dioxide can be reduced with a consequent reduction of acidification
and nutrient enrichment potentials. However, the conventional power plants still have lower acidification and nutrient enrichment
potentials.
Conclusions The study shows that incineration could not play the major role for electricity production, but in addition to being a waste
management option, could be considered as a complement to conventional power production. To promote incineration as a benign
waste management option, appropriate deNOx and dioxin removal processes should be provided. Separation of high moisture content waste fractions from the waste to be
incinerated and improvement of the operation efficiency of the incineration plant must be considered to improve the environmental
performance of MSW incineration.
Recommendations This study provides an overall picture and impacts, and hence, can support a decision-making process for implementation of
MSW incineration. The results obtained in this study could provide valuable information to implement incineration. But it
should be noted that the results show the characteristics only from some viewpoints.
Outlook Further analysis is required to evaluate the electricity production of the incineration plant from other environmental aspects
such as toxicity and land-use. 相似文献
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84.
Thu Lan T. Nguyen Shabbir H. Gheewala Sébastien Bonnet 《The International Journal of Life Cycle Assessment》2008,13(7):564-573
Background, aim, and scope
As a net oil importer, Thailand has a special interest in the development of biofuels, especially ethanol. At present, ethanol in the country is mainly a fermentation/distillery product of cane molasses, but cassava holds superior potential for the fuel. This study aims to assess the economics of cassava-based ethanol as an alternative transportation fuel in Thailand. The scope of the study includes the cassava cultivation/processing, the conversion to ethanol, the distribution of the fuel, and all transportation activities taking place within the system boundary.Materials and methods
The life cycle cost assessment carried out follows three interrelated phases: data inventory, data analysis, and interpretation. The functional unit for the comparison between ethanol and gasoline is the specific distance that a car can travel on 1 L ethanol in the form of E10, a 10% ethanol blend in gasoline.Results
The results of the analysis show, despite low raw material cost compared to molasses and cane-based ethanol, that cassava ethanol is still more costly than gasoline. This high cost has put an economic barrier to commercial application, leading to different opinions about government support for ethanol in the forms of tax incentives and subsidies.Discussion
Overall, feedstock cost tends to govern ethanol’s production cost, thus, making itself and its 10% blend in gasoline less competitive than gasoline for the specific conditions considered. However, this situation can also be improved by appropriate measures, as discussed later.Conclusions
To make ethanol cost-competitive with gasoline, the first possible measure is a combination of increasing crop yield and decreasing farming costs (chemical purchase and application, planting, and land preparation) so as to make a 47% reduction in the cost per tonne of cassava. This is modeled by a sensitivity analysis for the cost in the farming phase. In the industrial phase of the fuel production cycle, utilization of co-products and substitution of rice husk for bunker oil as process energy tend to reduce 62% of the price gap between ethanol and gasoline. The remaining 38% price gap can be eliminated with a 16% cut of raw material (cassava) cost, which is more practical than a 47% where no savings options in ethanol conversion phase are taken into account.Recommendations and perspectives
The life cycle cost analysis helps identify the key areas in the ethanol production cycle where changes are required to improve cost performance. Including social aspects in an LCC analysis may make the results more favorable for ethanol. 相似文献85.
Excessive production of nitric oxide (NO) as result of inducible nitric oxide synthase (iNOS) induction has been implicated in the pathophysiology of hemorrhagic shock. Our aim was to study the effects of NOS inhibitors, aminoguanidine (AG) and NG-nitro-L-arginine methyl ester (L-NAME), on survival rate, mean arterial blood pressure (MABP), temporal evolution of infarct volume, nitric oxide (NO) production and neurological deficit in a model of delayed hemorrhagic shock (DHS) in conscious rats. Our results showed that the NOS inhibitors significantly improved survival rate, MABP, and attenuated brain NO overproduction 24, 48 h and 72 h after DHS. AG reduced brain infarct volume and improved the neurological performance evaluated by the rotameric and grip strength tests while L-NAME did not show protective effect in rats following DHS. These findings suggest that NO formation via iNOS activation may contribute to organ damage and that the selective iNOS inhibitor, AG, may be of interest as a therapeutic agent for neurological recovery following DHS. 相似文献
86.
Identification and clinical characterization of Hermansky–Pudlak syndrome alleles in the Pakistani population
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87.
Puneet P Hegde A Ng SW Lau HY Lu J Moochhala SM Bhatia M 《Journal of immunology (Baltimore, Md. : 1950)》2006,176(6):3813-3820
Preprotachykinin-A (PPT-A) gene products substance P and neurokinin-A have been shown to play an important role in neurogenic inflammation. To investigate the role of PPT-A gene products in lung injury in sepsis, polymicrobial sepsis was induced by cecal ligation and puncture in PPT-A gene-deficient mice (PPT-A(-/-)) and the wild-type control mice (PPT-A(+/+)). PPT-A gene deletion significantly protected against mortality, delayed the onset of lethality, and improved the long-term survival following cecal ligation and puncture-induced sepsis. PPT-A(-/-) mice also had significantly attenuated inflammation and damage in the lungs. The data suggest that deletion of the PPT-A gene may have contributed to the disruption in recruitment of inflammatory cells resulting in protection against tissue damage, as in these mice the sepsis-associated increase in chemokine levels is significantly attenuated. 相似文献
88.
Eley L Moochhala SH Simms R Hildebrandt F Sayer JA 《Biochemical and biophysical research communications》2008,371(4):877-882
Nephronophthisis is characterised by renal fibrosis, tubular basement membrane disruption and corticomedullary cyst formation leading to end stage renal failure. Mutations in NPHP1 account for the underlying genetic defect in 25% of patients with nephronophthisis. Loss of urine concentration ability may be an early feature of nephronophthisis. Using yeast-2-library screening with the SH3 domain of nephrocystin-1 as bait, we identify Ack1 as a novel interaction partner. This interaction is confirmed using exogenous over-expression followed by co-immunoprecipitation. Ack1 is an activated Cdc42-associated kinase, and like nephrocystin-1, is a known interactor of p130Cas. Nephrocystin-1 partially colocalises with Ack1 at cell-cell contacts in IMCD3 cells. In human kidney, nephrocystin-1 expression is limited to cell-cell junctions in renal collecting duct cells. These data define Ack1 as a novel interaction partner of nephrocystin-1 and implicate cell-cell junctions and the renal collecting duct in the pathology of nephronophthisis. 相似文献
89.
Nam K. Chu Waheed Shabbir Erin Bove-Fenderson Can Araman Rosa Lemmens-Gruber David A. Harris Christian F. W. Becker 《The Journal of biological chemistry》2014,289(43):30144-30160
Membrane attachment via a C-terminal glycosylphosphatidylinositol anchor is critical for conversion of PrPC into pathogenic PrPSc. Therefore the effects of the anchor on PrP structure and function need to be deciphered. Three PrP variants, including full-length PrP (residues 23–231, FL_PrP), N-terminally truncated PrP (residues 90–231, T_PrP), and PrP missing its central hydrophobic region (Δ105–125, ΔCR_PrP), were equipped with a C-terminal membrane anchor via a semisynthesis strategy. Analyses of the interactions of lipidated PrPs with phospholipid membranes demonstrated that C-terminal membrane attachment induces a different binding mode of PrP to membranes, distinct from that of non-lipidated PrPs, and influences the biochemical and conformational properties of PrPs. Additionally, fluorescence-based assays indicated pore formation by lipidated ΔCR_PrP, a variant that is known to be highly neurotoxic in transgenic mice. This finding was supported by using patch clamp electrophysiological measurements of cultured cells. These results provide new evidence for the role of the membrane anchor in PrP-lipid interactions, highlighting the importance of the N-terminal and the central hydrophobic domain in these interactions. 相似文献
90.
Grace Kai Xin Tan Jowin Kai Wei Ng Kar Wai Tan Veronique Angeli Shabbir Moochhala Eng Eong Ooi Sylvie Alonso 《PloS one》2013,8(4)
Dengue (DEN) is a mosquito-borne viral disease and represents a serious public health threat and an economical burden throughout the tropics. Dengue clinical manifestations range from mild acute febrile illness to severe DEN hemorrhagic fever/DEN shock syndrome (DHF/DSS). Currently, resuscitation with large volumes of isotonic fluid remains the gold standard of care for DEN patients who develop vascular leakage and shock. Here, we investigated the ability of small volume of hypertonic saline (HTS) suspensions to control vascular permeability in a mouse model of severe DEN associated with vascular leakage. Several HTS treatment regimens were considered and our results indicated that a single bolus of 7.5% NaCl at 4 mL per kg of body weight administered at the onset of detectable vascular leakage rapidly and significantly reduced vascular leak for several days after injection. This transient reduction of vascular leakage correlated with reduced intestine and liver damage with restoration of the hepatic functions, and resulted in delayed death of the infected animals. Mechanistically, we showed that HTS did not directly impact on the viral titers but resulted in lower immune cells counts and decreased systemic levels of soluble mediators involved in vascular permeability. In addition, we demonstrated that neutrophils do not play a critical role in DEN-associated vascular leakage and that the therapeutic effect of HTS is not mediated by its impact on the neutrophil counts. Together our data indicate that HTS treatment can transiently but rapidly reduce dengue-associated vascular leakage, and support the findings of a recent clinical trial which evaluated the efficacy of a hypertonic suspension to impact on vascular permeability in DSS children. 相似文献