排序方式: 共有56条查询结果,搜索用时 0 毫秒
1.
G. Röhrborn V. Sezer I. -D. Adler A. Schmaltz I. H. Pawlowitzki Ch. Nautsch 《Human genetics》1978,42(1):55-58
Summary Mutagenic damages in female germ, cells of mice have been tested with the dominant, lethal assay and the cytogenetic analysis of unfertilized M II-oocytes. Concluding one can say that from the experimental data presented here do not show any mutagenic effect of INH on oogenesis of different strains of mice can be stated. 相似文献
2.
Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease 总被引:3,自引:0,他引:3
Heider U Hofbauer LC Zavrski I Kaiser M Jakob C Sezer O 《Biochemical and biophysical research communications》2005,338(2):687-693
Increased bone resorption is a major characteristic of multiple myeloma and is caused by osteoclast activation and osteoblast inhibition (uncoupling). Myeloma cells alter the local regulation of bone metabolism by increasing the receptor activator of NF-kappaB ligand (RANKL) and decreasing osteoprotegerin expression within the bone marrow microenvironment, thereby stimulating the central pathway for osteoclast formation and activation. In addition, they produce the chemokines MIP-1alpha, MIP-1beta, and SDF-1alpha, which also increase osteoclast activity. On the other hand, myeloma cells suppress osteoblast function by the secretion of osteoblast inhibiting factors, e.g., the Wnt inhibitors DKK-1 and sFRP-2. Moreover, they inhibit differentiation of osteoblast precursors and induce apoptosis in osteoblasts. The resulting bone destruction releases several cytokines, which in turn promote myeloma cell growth. Therefore, the inhibition of bone resorption could stop this vicious circle and not only decrease myeloma bone disease, but also the tumor progression. 相似文献
3.
Genome-wide fungal stress responsive miRNA expression in wheat 总被引:2,自引:0,他引:2
Behçet Inal Mine Türktaş Hakan Eren Emre Ilhan Sezer Okay Mehmet Atak Mustafa Erayman Turgay Unver 《Planta》2014,240(6):1287-1298
4.
5.
Granulocyte–macrophage colony-stimulating factor (GM-CSF) is a cytokine used in the treatment of serious conditions resulting
from chemotherapy and bone marrow transplantation such as neutropenia and aplastic anemia. Despite these effects, GM-CSF has
a very short biological half-life, and it requires frequent injection during the treatment. Therefore, the cytokine production
is possible in the body with plasmid-encoded GM-CSF (pGM-CSF) coding for cytokine administered to the body. However, the selection
of the proper delivery system for the plasmid is important. In this study, two different delivery systems, encapsulated plasmid
such as fucoidan–chitosan (fucosphere) and chitosan microspheres, were prepared and the particle physicochemical properties
evaluated. Fucospheres and chitosan microspheres size ranges are 151–401 and 376–681 nm. The zeta potential values of the
microspheres were changed between 8.3–17.1 mV (fucosphere) and +21.9–28.9 mV (chitosan microspheres). The encapsulation capacity
of fucospheres changed between 84.2% and 94.7% depending on the chitosan molecular weight used in the formulation. In vitro plasmid DNA release from both delivery systems exhibited slower profiles of approximately 90–140 days. Integrity of released
samples was checked by agarose gel electrophoresis, and any additional band was not seen. All formulations were analyzed kinetically.
The calculated regression coefficients showed a higher r
2 value with zero-order kinetics. In conclusion, the characterizations of the microspheres can be modulated by changing the
formulation variables, and it can be concluded that fucospheres might be a potential carrier system for the controlled delivery
of GM-CSF encoding plasmid DNA. 相似文献
6.
Modularly upgradable product designs have been advocated to offer environmental and economic advantages; however, they are not commonly used in the consumer electronics industry. In this article, we investigate the economic and environmental benefits and challenges of modular upgradability for consumer electronics. From an economic point of view, we posit that the limited adoption of modular upgradability in consumer electronics is owing to various demand‐, technology‐, and competition‐related issues. From an environmental point of view, we posit that modularly upgradable product designs may not necessarily lead to superior environmental outcomes. To reach meaningful conclusions regarding the environmental benefits of modular upgradability, one needs to understand how product architecture affects demand, production, and consumption patterns, which arise from endogenous consumer and manufacturer choices. It is also important to take into account that modular upgradability may have potentially differentiated effects in the production, consumption, and postuse phases of the lifecycle. 相似文献
7.
The primary structure of the calmodulin-sensitive adenylate cyclase toxin from Bacillus anthracis has been determined from the corresponding nucleotide sequence and compared to that of the homologous toxin secreted by Bordetella pertussis. The cya gene of Bacillus anthracis encodes an 800 amino acid (aa) protein beginning with an N-terminal signal peptide. The central part of the B. anthracis adenylate cyclase includes a region of striking homology with the N-terminal part of the B. pertussis enzyme. In this region a particularly well conserved 24-aa peptide and two other less homologous peptides have been identified. These data corroborate the immunological relatedness of the two enzymes and suggest that the two prokaryotic calmodulin-sensitive adenylate cyclases originate from a common ancestor. 相似文献
8.
M Sardan S Sezer A Günel M Akkaya C Tanyeli 《Bioorganic & medicinal chemistry letters》2012,22(18):5814-5818
An efficient synthesis of racemic and both enantiomeric forms of heteroaryl substituted γ- and δ-lactone derivatives derived from allyl and homoallyl alcohol backbones has been accomplished via ring closing metathesis reaction. 2-Heteroaryl substituted allyl and homoallyl alcohols have been efficiently resolved through enzymatic method with high ee (97-99%) and known stereochemistry. Antimicrobial and antioxidant activities of target lactones were evaluated. 相似文献
9.
10.