排序方式: 共有110条查询结果,搜索用时 15 毫秒
31.
Abdol-Mohammad Kajbafzadeh Seyed Hossein Ahmadi Tafti Reza Khorramirouz Shabnam Sabetkish Seyedeh Maryam Kameli Saghar Orangian Shahram Rabbani Nasim Oveisi Marziyeh Golmohammadi Zeynab Kashani 《Cell and tissue banking》2017,18(4):527-538
Inappropriate left ventricular remodeling following myocardial infarction (MI) can result in subsequent severe dysfunction. In this study, we tested the hypothesis that decellularized pericardium (DP) or seeded pericardial patch with autologous adipose-derived mesenchymal stem cells (ADMSCs) could be safely used in a MI scar and could improve heart function. Twelve rabbits were randomly divided into three equal groups. Four weeks after MI induction by ligation of the left anterior descending artery in 12 rabbits, animals of G1 (n = 4) received DP patch with labeled ADMSCs. DP patch was implanted in animals of G2 (n = 4). Rabbits of G3 (n = 4) remained without any intervention after MI induction (control group). Serial examinations including echocardiography, electrocardiography (ECG), scanning electron microscopy, histology and immunohistochemistry (IHC) were performed to evaluate the efficacy of the implanted scaffolds on recovery of the infracted myocardium. The results demonstrated that left ventricular contractile function and myocardial pathological changes were significantly improved in rabbits implanted with either DP or ADMSC-seeded pericardium. However, the seeded pericardium was more effective in scar repairing 2 months after the operation, IHC staining with Desmin and CD34 and positive immunofluorescence staining verified the differentiation of ADMSCs to functional cardiomyocytes. This approach may involve the application of autologous ADMSCs seeded on pericardial patch in an attempt to regenerate a contractible myocardium in an animal model of MI. 相似文献
32.
Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure 下载免费PDF全文
33.
Vafaei Maryam Naseri Mahmood Abedi Elahe Babaei Seyedeh Sedigheh Imani Ahmad Torri Luisa 《Biological trace element research》2020,193(1):261-270
Biological Trace Element Research - The kinetic reaction for changes in some essential mineral contents (iron, zinc, calcium, sodium, and copper) of silver carp canned in sunflower oil, soybean... 相似文献
34.
Ayatollahi Hossein Mousavi Nezhad Seyedeh Fatemeh Talebpour Amir Badiei Zahra Nezami Hossein 《Molecular biology reports》2020,47(12):9353-9359
Molecular Biology Reports - Iron overload is the main cause of morbidity and mortality in β-thalassemia major patients, and cardiac iron overload is the most common reason for death in these... 相似文献
35.
A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation 总被引:2,自引:1,他引:1 下载免费PDF全文
Motazacker MM Rost BR Hucho T Garshasbi M Kahrizi K Ullmann R Abedini SS Nieh SE Amini SH Goswami C Tzschach A Jensen LR Schmitz D Ropers HH Najmabadi H Kuss AW 《American journal of human genetics》2007,81(4):792-798
Nonsyndromic mental retardation is one of the most important unresolved problems in genetic health care. Autosomal forms are far more common than X-linked forms, but, in contrast to the latter, they are still largely unexplored. Here, we report a complex mutation in the ionotropic glutamate receptor 6 gene (GRIK2, also called “GLUR6”) that cosegregates with moderate-to-severe nonsyndromic autosomal recessive mental retardation in a large, consanguineous Iranian family. The predicted gene product lacks the first ligand-binding domain, the adjacent transmembrane domain, and the putative pore loop, suggesting a complete loss of function of the GLUK6 protein, which is supported by electrophysiological data. This finding provides the first proof that GLUK6 is indispensable for higher brain functions in humans, and future studies of this and other ionotropic kainate receptors will shed more light on the pathophysiology of mental retardation. 相似文献
36.
Hashemzadeh Segherloo Iraj Najafi Chaloshtory Sajad Naser Murtada D. Yasser Amaal Gh. Tabatabaei Seyedeh Narjes Piette-Lauziere Gabriel Mashtizadeh Amirhossein Elmi Amirmohammad Sedighi Omid Changizi Alieh Hallerman Eric Bernatchez Louis 《Environmental Biology of Fishes》2022,105(9):1251-1260
Environmental Biology of Fishes - Among Tashan cave barb Garra tashanensis inhabiting a small cave in southwest Iran, two mental disc (sucking mouth disc) forms were observed. To assess their... 相似文献
37.
Mohammad Tajfard Seyedeh Belin Tavakoly Sany Amir Avan Latiffah A. Latiff Hamid Reza Rahimi Mohsen Moohebati Mehdi Hasanzadeh Hamideh Ghazizadeh Habibollah Esmaeily Hassan Doosti Ali Taghipour Majid Ghayour-Mobarhan Gordon A. Ferns Marzie Emamian Mohd Sokhini Bin Abd Mutalib 《Journal of cellular physiology》2019,234(7):10289-10299
Serum high-sensitivity C-reactive protein (hs-CRP) is predictive of coronary artery disease (CAD). The aim of this study was to examine the possible association of hs-CRP with presence and severity of CAD and traditional CAD risk factors. This case-control study was carried out on 2,346 individuals from September 2011 to May 2013. Of these 1,187 had evidence of coronary disease, and were subject to coronary angiography, and the remainder were healthy controls (n = 1,159). Characteristics were determined using standard laboratory techniques and serum Hs-CRP levels were estimated using enzyme-linked immunosorbent assay (ELISA) kits, and severity of CAD was assessed according to the score of obstruction in coronary artery. Serum hs-CRP levels were higher in those with severe coronary disease, who had stenosis ≥ 50% stenosis of at least one coronary artery (all p < 0.001 vs. individuals in healthy control), and correlated significantly with the score for coronary artery disease (all p < 0.01). After adjustment for conventional risk factors, regression analysis revealed that smoking habits, fasting blood glucose, total cholesterol, high-density lipoprotein, hs-CRP, blood pressure, anxiety, dietary intake of vitamin E, and cholesterol remained as independent determinants for angiographic severity of CAD. The area under the receiving operating characteristic (ROC) curve for serum hs-CRP was 0.869 (CI 95% 0.721–0.872, p < 0.001). The optimal values for the cut-off point was a serum hs-CRP of 2.78 mg/l (sensitivity 80.20%, specificity 85%) to predict severity of CAD. Increased serum hs-CRP levels are significantly associated with angiographic severity of CAD, suggesting its value as a biomarkers for predicting CAD. 相似文献
38.
Hashemi Mohammad Sadeghi Abbas Saghi Masoumeh Aminzare Majid Raeisi Mojtaba Rezayi Majid Sany Seyedeh Belin Tavakoly 《Biological trace element research》2019,188(2):485-493
Biological Trace Element Research - The relative contribution of foodstuffs to intake of heavy metal is still equivocal, and thus, available data are rare. Here, the concentration of ten heavy... 相似文献
39.
Hosseini Seyedeh Arezoo Tahmoorespur Mojtaba Sekhavati Mohammad Hadi Monhemi Hassan Nassiri Mohammadreza 《International journal of peptide research and therapeutics》2019,25(4):1459-1465
International Journal of Peptide Research and Therapeutics - One major issue in cancer immunotherapy is the large size of mAbs (150 kDa) which usually causes limitation in tumor... 相似文献
40.
Mohammadi Shiva Mostafavi-Pour Zohreh Ghasemi Younes Barazesh Mahdi Kavousi Pour Soudabeh Atapour Amir Mokarram Pooneh Morowvat Mohammad Hossein 《International journal of peptide research and therapeutics》2019,25(4):1279-1290
International Journal of Peptide Research and Therapeutics - Escherichia coli is one of the simplest hosts which is widely being used to express heterologous proteins. However, without appropriate... 相似文献