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991.
Choi DS Lee JM Park GW Lim HW Bang JY Kim YK Kwon KH Kwon HJ Kim KP Gho YS 《Journal of proteome research》2007,6(12):4646-4655
Microvesicles (MV) are membrane vesicles secreted from the plasma and endosomal membrane compartment by various cell types such as hematopoietic, epithelial, and tumor cells. Actively growing tumor cells shed MV, and the rate of shedding increases in malignant tumors. Although recent progress in this area has revealed that tumor-derived MV play multiple roles in tumor growth and metastasis via immune escape, tumor invasion, and angiogenesis, the mechanism of vesicle formation and the biological roles of tumor-derived MV are not understood. Here, we report the first global proteomic analysis of highly purified MV from human colorectal cancer cells. Using 1D SDS gel electrophoresis and nano-LC-MS/MS analyses, we identified a total of 547 microvesicular proteins from three independent experiments with high confidence; 416 proteins were identified at least in two trials, including 181 as yet unreported proteins. We identified 49 proteins involved in the biogenesis of MV, including annexins, ADP-ribosylation factors, and Rab proteins. We also identified 28 proteins that may function in tumorigenesis via promotion of migration, invasion, and growth of tumor cells, immune modulation, metastasis, and angiogenesis. Taken together with previously reported results, our observations suggest that tumor-derived MV may act as communicasomes, that is, extracellular organelles that play diverse roles in intercellular communication. This information will help elucidate the biogenesis and functions of tumor-derived MV, and aid in the development of effective vaccines for various cancers, including colorectal cancer. 相似文献
992.
Linxue Shang Dandan Ma Sidan Hong Yu Zhao Guozhe Zhang Qingqing Ma Qun Wang Cuihua Gu 《Phyton》2022,91(12):2607-2617
Flower bud differentiation is a key component of plant blooming biology and understanding how it works is vital
for flowering regulation and plant genetic breeding, increasing the number and quality of flowering. Red soil is the
most widely covered soil type in the world, and it is also the most suitable soil type for crape myrtle planting. The
flower buds of crape myrtle (Lagerstroemia indica) planted in red soil were employed as experimental materials in
this study, and the distinct periods of differentiation were identified using stereomicroscopy and paraffin sectioning. We optimized the steps of dehydration, transparency, embedding, sectioning and staining when employing
paraffin sections. When seen under a microscope, this optimization can make the cell structure of paraffin sections obvious, the tissue structure complete, and the staining clear and natural. The flower bud differentiation
process is divided into 7 periods based on anatomical observations of the external morphology and internal structure during flower bud differentiation: undifferentiated period, start of differentiation period, inflorescence differentiation period, calyx differentiation period, petal differentiation period, stamen differentiation period, and pistil
differentiation period. The differentiation time is concentrated from the end of May to mid-June. Crape myrtle
flower bud differentiation is a complicated process, and the specific regulatory mechanism and affecting elements
need to be investigated further. 相似文献
993.
Ho Kuo-Hao Chen Peng-Hsu Shih Chwen-Ming Lee Yi-Ting Cheng Chia-Hsiung Liu Ann-Jeng Lee Chin-Cheng Chen Ku-Chung 《Cellular and molecular neurobiology》2022,42(3):791-806
Cellular and Molecular Neurobiology - The insulin-like growth factor (IGF)-1 and transforming growth factor (TGF)-β signal pathways are both recognized as important in regulating cancer... 相似文献
994.
Molecular and Cellular Biochemistry - LINC00184 has been suggested to be associated with cancer prognosis and has been implicated in cancer glycolysis; however, its role in oesophageal squamous... 相似文献
995.
Hong Yu Sun He Hong Xian Yang Cai-Ping Billadeau Daniel D. Wang Tao Deng Zhi-Hui 《Molecular biology reports》2022,49(9):8349-8357
Molecular Biology Reports - WASHC1 is a member of the Wiskott-Aldrich syndrome protein (WASP) family and is involved in endosomal protein sorting and trafficking through the generation of... 相似文献
996.
Zhao Dawei Wu Di Zhang Gengyue Li Yongqi Shi Weiguo Zhong Bohua Yu Hong 《Molecular biology reports》2022,49(9):8359-8368
Molecular Biology Reports - Irinotecan (CPT-11) is a camptothecin derivative whose potent anti-tumor activity depends on the rapid formation of an in vivo active metabolite, SN38... 相似文献
997.
Xia Xiu-Jiao Shen Hong Zhi Hui-Lin Zhong Yan Sang Bo Lv Wen-Wen Li Qiu-Ping Liu Ze-Hu 《Mycopathologia》2022,187(2-3):189-197
Mycopathologia - Deep cutaneous fungal infections including deep dermatophytosis are responsible for significant morbidity and mortality, especially in immunocompromised patients. Variable and... 相似文献
998.
999.