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排序方式: 共有240条查询结果,搜索用时 406 毫秒
111.
112.
K. S. Seshadri Ramit Singal H. Priti G. Ravikanth M. K. Vidisha S. Saurabh M. Pratik Kotambylu Vasudeva Gururaja 《PloS one》2016,11(3)
In recent times, several new species of amphibians have been described from India. Many of these discoveries are from biodiversity hotspots or from within protected areas. We undertook amphibian surveys in human dominated landscapes outside of protected areas in south western region of India between years 2013–2015. We encountered a new species of Microhyla which is described here as Microhyla laterite sp. nov. It was delimited using molecular, morphometric and bioacoustics comparisons. Microhyla laterite sp. nov. appears to be restricted to areas of the West coast of India dominated by laterite rock formations. The laterite rock formations date as far back as the Cretaceous-Tertiary boundary and are considered to be wastelands in-spite of their intriguing geological history. We identify knowledge gaps in our understanding of the genus Microhyla from the Indian subcontinent and suggest ways to bridge them. 相似文献
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114.
Tapasa Kumar Sahoo Prasant Kumar Jena Bhumika Prajapati Laxita Gehlot Amiya Kumar Patel Sriram Seshadri 《Probiotics and antimicrobial proteins》2017,9(3):345-354
Bacteriocin TSU4 is a novel antimicrobial peptide isolated from Catla catla gut isolate Lactobacillus animalis TSU4. It has been reported for its potential antimicrobial activity against fish pathogens and food spoilage bacteria. In vivo safety evaluation is necessary to determine its immunogenicity, toxicity, and importance in real-life applications. The present study was designed to evaluate the immunogenicity, acute and sub-chronic toxicity of bacteriocin TSU4 in BALB/c mice to ensure its safety in industrial application. Male BALB/c mice were administered intraperitoneally for immunogenicity assessment, by oral gavage with 50, 100, and 200 mg/kg/body weight for acute test and 0.5 mg/kg/day dose of bacteriocin TSU4 for sub-chronic toxicity test. Neither mortality nor any infections were observed during experimental period. There was no major increase in antibody titer during the immunogenicity test, and no mortality was observed during acute or sub-chronic toxicity tests. The LD50 value of bacteriocin TSU4 was found to be higher than 200 ± 0.45 mg/kg. No significant change in the serum biochemical markers, histopathological analysis and visual observation in spleen sizes was observed. These findings revealed that bacteriocin TSU4 is a non-immunogenic, safe, non-toxic, and could be a potential candidate for industrial applications in food preservation and aquaculture industries. 相似文献
115.
Gunasekaran S Arunbalaji R Kumaresan S Seshadri S Muthu S 《Journal of molecular modeling》2008,14(5):375-383
The FTIR and Laser-Raman spectra of paraldehyde have been recorded in the regions 4000–400 cm−1 and 3500–250 cm−1 respectively. Molecular electronic energy, geometrical structure, harmonic vibrational spectra, infrared intensities and
Raman scattering activities have been computed at the HF/6-31G(d,p) and B3LYP/6-31G(d,p) levels of theory. The results were
compared with experimental values with the help of scaling procedures. The observed wave numbers in FTIR and Laser-Raman spectra
were analyzed and assigned to different normal modes of the molecule. Most of the modes have wave numbers in the expected
range and are in good agreement with computed values. 相似文献
116.
Kamal A Kumar PP Seshadri BN Srinivas O Kumar MS Sen S Kurian N Juvekar AS Zingde SM 《Bioorganic & medicinal chemistry》2008,16(7):3895-3906
Pyrrolobenzodiazepine-diethylphosphonate conjugates have been designed and synthesized that link through two different types of spacers that are simple alkane chain and also a piperazine moiety side-armed with the alkane chains. These pyrrolobenzodiazepine conjugates have exhibited remarkable DNA-binding affinity and improved solubility in water, a representative compound 7d showing promising in vitro cytotoxicity. 相似文献
117.
Malaikozhundan B Suresh P Seshadri S Janarthanan S 《Indian journal of experimental biology》2003,41(12):1463-1465
Arcelin, an anti-metabolic protein was purified from the seeds of wild bean, Lablab purpureus. The feeding assay containing arcelin at 5, 10 and 15 microg concentrations revealed no antifeedant effect against fifth instar larvae of S. litura. However, the enhanced activity of alpha- and beta-naphthyl esterases in the mid-gut samples of S. litura treated with arcelin suggests countermeasure against the toxic effect of arcelin. 相似文献
118.
Mitra SK Sachan A Udupa V Seshadri SJ Jayakumar K 《Indian journal of experimental biology》2003,41(3):211-215
Efficacy of Diarex-Vet (The Himalaya Drug Company, Makali, Bangalore, India) was evaluated histologically in semichronic diarrhoea induced by lactose enriched diet in rats. The rats in different groups were given lactose enriched diet alone for 2 days before starting the treatment with Diarex-Vet at a dose of 250, 500 and 750 mg/kg body weight along with lactose enriched diet for 5 days. Animals were euthanised at the end of 5 days of treatment and histological changes were observed in the ileum, caecum and colon. Semiquantitative analysis of goblet cells in intestines showed dose dependent response among the treated groups. The morphological changes were comparable to normal in the group given 750 mg/kg body wt Diarex-Vet. The effects observed were attributed to the lactase like analogous activity of Diarex-Vet or the inhibition of the osmotic processes in the intestinal lumen thereby reducing the morphological changes in the intestines. 相似文献
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120.
Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis 总被引:1,自引:0,他引:1
Heidelberg JF Paulsen IT Nelson KE Gaidos EJ Nelson WC Read TD Eisen JA Seshadri R Ward N Methe B Clayton RA Meyer T Tsapin A Scott J Beanan M Brinkac L Daugherty S DeBoy RT Dodson RJ Durkin AS Haft DH Kolonay JF Madupu R Peterson JD Umayam LA White O Wolf AM Vamathevan J Weidman J Impraim M Lee K Berry K Lee C Mueller J Khouri H Gill J Utterback TR McDonald LA Feldblyum TV Smith HO Venter JC Nealson KH Fraser CM 《Nature biotechnology》2002,20(11):1118-1123
Shewanella oneidensis is an important model organism for bioremediation studies because of its diverse respiratory capabilities, conferred in part by multicomponent, branched electron transport systems. Here we report the sequencing of the S. oneidensis genome, which consists of a 4,969,803-base pair circular chromosome with 4,758 predicted protein-encoding open reading frames (CDS) and a 161,613-base pair plasmid with 173 CDSs. We identified the first Shewanella lambda-like phage, providing a potential tool for further genome engineering. Genome analysis revealed 39 c-type cytochromes, including 32 previously unidentified in S. oneidensis, and a novel periplasmic [Fe] hydrogenase, which are integral members of the electron transport system. This genome sequence represents a critical step in the elucidation of the pathways for reduction (and bioremediation) of pollutants such as uranium (U) and chromium (Cr), and offers a starting point for defining this organism's complex electron transport systems and metal ion-reducing capabilities. 相似文献