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921.
Alberto Jiménez-Maldonado Elena Roces de álvarez-Buylla Sergio Montero Valery Melnikov Elena Castro-Rodríguez Armando Gamboa-Domínguez Alejandrina Rodríguez-Hernández Mónica Lemus Jesús Mu?iz Murguía 《PloS one》2014,9(12)
Background
Physical exercise improves glucose metabolism and insulin sensitivity. Brain-derived neurotrophic factor (BDNF) enhances insulin activity in diabetic rodents. Because physical exercise modifies BDNF production, this study aimed to investigate the effects of chronic exercise on plasma BDNF levels and the possible effects on insulin tolerance modification in healthy rats.Methods
Wistar rats were divided into five groups: control (sedentary, C); moderate- intensity training (MIT); MIT plus K252A TrkB blocker (MITK); high-intensity training (HIT); and HIT plus K252a (HITK). Training comprised 8 weeks of treadmill running. Plasma BDNF levels (ELISA assay), glucose tolerance, insulin tolerance, and immunohistochemistry for insulin and the pancreatic islet area were evaluated in all groups. In addition, Bdnf mRNA expression in the skeletal muscle was measured.Principal Findings
Chronic treadmill exercise significantly increased plasma BDNF levels and insulin tolerance, and both effects were attenuated by TrkB blocking. In the MIT and HIT groups, a significant TrkB-dependent pancreatic islet enlargement was observed. MIT rats exhibited increased liver glycogen levels following insulin administration in a TrkB-independent manner.Conclusions/Significance
Chronic physical exercise exerted remarkable effects on insulin regulation by inducing significant increases in the pancreatic islet size and insulin sensitivity in a TrkB-dependent manner. A threshold for the induction of BNDF in response to physical exercise exists in certain muscle groups. To the best of our knowledge, these are the first results to reveal a role for TrkB in the chronic exercise-mediated insulin regulation in healthy rats. 相似文献922.
We show that preschoolers exhibit the endowment effect as evidenced by experiments where children generally chose to keep their own toys rather than trading them for similar ones. Furthermore, we relate the emergence of this effect to children''s innate psychobiological traits—emotional state, gender, handedness, and digit ratio. The trials were conducted with 141 children across 6 kindergartens. We also found support that children, like adults, exhibit a preference for physical possession as opposed to ownership. As with adults, emotions also seem to matter, as children who were described as quiet and calm were more likely to present the endowment effect. Also of note, right-handed children described as quiet were more likely to exhibit the phenomenon. Furthermore, female children were generally found to be calmer than males, while males tended to be more fearful than females. This result was also previously found in teenagers. 相似文献
923.
Sergio Camero María J. Benítez Raquel Cuadros Félix Hernández Jesús ávila Juan S. Jiménez 《PloS one》2014,9(8)
Tau hyperphosphorylation can be considered as one of the hallmarks of Alzheimer''s disease and other tauophaties. Besides its well-known role as a microtubule associated protein, Tau displays a key function as a protector of genomic integrity in stress situations. Phosphorylation has been proven to regulate multiple processes including nuclear translocation of Tau. In this contribution, we are addressing the physicochemical nature of DNA-Tau interaction including the plausible influence of phosphorylation. By means of surface plasmon resonance (SPR) we measured the equilibrium constant and the free energy, enthalpy and entropy changes associated to the Tau-DNA complex formation. Our results show that unphosphorylated Tau binding to DNA is reversible. This fact is in agreement with the protective role attributed to nuclear Tau, which stops binding to DNA once the insult is over. According to our thermodynamic data, oscillations in the concentration of dephosphorylated Tau available to DNA must be the variable determining the extent of Tau binding and DNA protection. In addition, thermodynamics of the interaction suggest that hydrophobicity must represent an important contribution to the stability of the Tau-DNA complex. SPR results together with those from Tau expression in HEK cells show that phosphorylation induces changes in Tau protein which prevent it from binding to DNA. The phosphorylation-dependent regulation of DNA binding is analogous to the Tau-microtubules binding inhibition induced by phosphorylation. Our results suggest that hydrophobicity may control Tau location and DNA interaction and that impairment of this Tau-DNA interaction, due to Tau hyperphosphorylation, could contribute to Alzheimer''s pathogenesis. 相似文献
924.
We replicate the Stanford marshmallow experiment with a sample of 141 preschoolers and find a correlation between lack of self-control and 2D:4D digit ratio. Children with low 2D:4D digit ratio are less likely to delay gratification. Low 2D:4D digit ratio may indicate high fetal testosterone. If this hypothesis is true, our finding means high fetal testosterone children are less likely to delay gratification. 相似文献
925.
Priscila P. Santos Fernando Oliveira Vanessa C. M. P. Ferreira Bertha F. Polegato Meliza G. Roscani Ana Angelica Fernandes Pamela Modesto Bruna P. M. Rafacho Silmeia G. Zanati Annarita Di Lorenzo Luiz S. Matsubara Sergio A. R. Paiva Leonardo A. M. Zornoff Marcos F. Minicucci Paula S. Azevedo 《PloS one》2014,9(12)
Background/Aims
Experimental and clinical studies have shown the direct toxic effects of cigarette smoke (CS) on the myocardium, independent of vascular effects. However, the underlying mechanisms are not well known.Methods
Wistar rats were allocated to control (C) and cigarette smoke (CS) groups. CS rats were exposed to cigarette smoke for 2 months.Results
After that morphometric, functional and biochemical parameters were measured. The echocardiographic study showed enlargement of the left atria, increase in the left ventricular systolic volume and reduced systolic function. Within the cardiac metabolism, exposure to CS decreased beta hydroxy acyl coenzyme A dehydrogenases and citrate synthases and increased lactate dehydrogenases. Peroxisome proliferator-activated receptor alpha (PPARα) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) were expressed similarly in both groups. CS increased serum lipids and myocardial triacylglycerols (TGs). These data suggest that impairment in fatty acid oxidation and the accumulation of cardiac lipids characterize lipotoxicity. CS group exhibited increased oxidative stress and decreased antioxidant defense. Finally, the myocyte cross-sectional area and active Caspase 3 were increased in the CS group.Conclusion
The cardiac remodeling that was observed in the CS exposure model may be explained by abnormalities in energy metabolism, including lipotoxicity and oxidative stress. 相似文献926.
Guilherme O. Longo Carlos Eduardo L. Ferreira Sergio R. Floeter 《Ecology and evolution》2014,4(23):4553-4566
Trophic interactions play a critical role in the structure and function of ecosystems. Given the widespread loss of biodiversity due to anthropogenic activities, understanding how trophic interactions respond to natural gradients (e.g., abiotic conditions, species richness) through large‐scale comparisons can provide a broader understanding of their importance in changing ecosystems and support informed conservation actions. We explored large‐scale variation in reef fish trophic interactions, encompassing tropical and subtropical reefs with different abiotic conditions and trophic structure of reef fish community. Reef fish feeding pressure on the benthos was determined combining bite rates on the substrate and the individual biomass per unit of time and area, using video recordings in three sites between latitudes 17°S and 27°S on the Brazilian Coast. Total feeding pressure decreased 10‐fold and the composition of functional groups and species shifted from the northern to the southernmost sites. Both patterns were driven by the decline in the feeding pressure of roving herbivores, particularly scrapers, while the feeding pressure of invertebrate feeders and omnivores remained similar. The differential contribution to the feeding pressure across trophic categories, with roving herbivores being more important in the northernmost and southeastern reefs, determined changes in the intensity and composition of fish feeding pressure on the benthos among sites. It also determined the distribution of trophic interactions across different trophic categories, altering the evenness of interactions. Feeding pressure was more evenly distributed at the southernmost than in the southeastern and northernmost sites, where it was dominated by few herbivores. Species and functional groups that performed higher feeding pressure than predicted by their biomass were identified as critical for their potential to remove benthic biomass. Fishing pressure unlikely drove the large‐scale pattern; however, it affected the contribution of some groups on a local scale (e.g., large‐bodied parrotfish) highlighting the need to incorporate critical functions into conservation strategies. 相似文献
927.
Minimal models of top-down control of phytoplankton 总被引:5,自引:0,他引:5
1. A set of models describing the dynamics of top-down control of phytoplankton by Daphnia in lakes is reviewed. The basis of these models is a simple and well-known model that has been used, among other things, to demonstrate the paradox of enrichment.
2. We discuss minimal extensions that allow this model to mimic the effects of spatial heterogeneity, planktivory, seasonality and inedible algae.
3. These models generate hypotheses about mechanisms that may cause patterns observed in the field such as:
4. We discuss the way in which such very simple models may contribute to the building of theories about plankton dynamics in the field, and the caveats of interpreting wrongly the message from models. 相似文献
2. We discuss minimal extensions that allow this model to mimic the effects of spatial heterogeneity, planktivory, seasonality and inedible algae.
3. These models generate hypotheses about mechanisms that may cause patterns observed in the field such as:
4. We discuss the way in which such very simple models may contribute to the building of theories about plankton dynamics in the field, and the caveats of interpreting wrongly the message from models. 相似文献
928.
The interaction of fast and slow processes is an integral part of the sudden large shifts that sometimes occur in ecosystems.
To study the effects of slow/fast variables on ecosystems, we used a range of examples from natural and exploited aquatic
and terrestrial systems. So-called catastrophic bifurcations in the dynamics of the fast components are at the heart of such
dramatic shifts. We discuss some of the most important bifurcations and show how they can be analyzed. Subsequently, we show
how the interaction with slowly changing variables can be understood from graphs constructed in a simple way using the singular
perturbation approach.
Received 30 November 1999; accepted 30 May 2000. 相似文献
929.
Elia Escasany Borja Lanzn Almudena García-Carrasco Adriana Izquierdo-Lahuerta Lucía Torres Patricia Corrales Ana Elena Rodríguez Rodríguez Sergio Luis-Lima Concepcin Martínez lvarez Francisco Javier Ruperez Manuel Ros Esteban Porrini Mikael Rydn Gema Medina-Gmez 《Disease models & mechanisms》2021,14(9)
930.
Effect of climatic variation on the relative abundance of the red alga Gelidium robustum in Baja California Sur, Mexico 总被引:1,自引:0,他引:1
Claudia J. Hernández-Guerrero Margarita Casas-Valdez Sofia Ortega-García Sergio Hernández-Vazquez 《Journal of applied phycology》2000,12(2):177-183
The red alga Gelidium robustum is important,because of its commercial exploitation in Mexico as araw material for the agar industry, providing 10% ofthe world production of agarophytes. In recent years,its annual harvest in Mexico has shownobvious,variations partly because of an increasedharvesting effort, but also because of environmentalchanges. An analysis is presented of the effect thatinterannual variability of the sea surfacetemperature, wind speed, and upwelling index had onthe relative abundance of this alga from 1980 to 1990.The results indicate a close relation betweenenvironmental fluctuations and the relative abundanceof this species. The response of G. robustum tothe different environmental conditions has not alwaysbeen equal. During El Niño 1982–84, the seasurface temperature was the most important factor andthere was a high negative correlation with therelative abundance. A lag period of three monthsshowed a positive correlation with upwelling index andwind speed. Under normal conditions and during LaNiña, the relative abundance of the alga showed apositive correlation with the sea surface temperature. For the upwelling index and wind speed, therelationship was similar to that during El Niño. 相似文献