全文获取类型
收费全文 | 359篇 |
免费 | 9篇 |
出版年
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 3篇 |
2017年 | 4篇 |
2016年 | 5篇 |
2014年 | 11篇 |
2012年 | 8篇 |
2011年 | 14篇 |
2010年 | 13篇 |
2009年 | 4篇 |
2008年 | 9篇 |
2007年 | 2篇 |
2006年 | 8篇 |
2005年 | 11篇 |
2004年 | 15篇 |
2003年 | 9篇 |
2002年 | 15篇 |
2001年 | 7篇 |
2000年 | 18篇 |
1999年 | 8篇 |
1998年 | 2篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 11篇 |
1991年 | 21篇 |
1990年 | 16篇 |
1989年 | 11篇 |
1988年 | 4篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 5篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1982年 | 1篇 |
1979年 | 2篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1975年 | 7篇 |
1974年 | 9篇 |
1973年 | 13篇 |
1972年 | 5篇 |
1971年 | 7篇 |
1970年 | 8篇 |
1969年 | 1篇 |
1968年 | 6篇 |
1967年 | 4篇 |
1965年 | 2篇 |
排序方式: 共有368条查询结果,搜索用时 671 毫秒
61.
A S Sergeev 《Genetika》1991,27(11):2020-2033
One of the implicit assumptions of the single locus model, having been used so far in the analysis of linkage between the genetic marker locus and the disease predisposition locus, is the requirement of independent--from the rest of genotype--action of genotypes of the disease predisposition locus considered. In this communication, it is emphasized that the lack of this requirement makes problematical the theoretical substantiation of the affected sib-pair method in the linkage analysis. To remove this obstacle, explicit pointing out of independence of the action of the single locus genotypes on the rest of the genotype is necessary in formulating of the single locus model which, with due regard for this assumption, represents a special, perhaps, unique case of the gene action characterized by incomplete differential penetrances of the genotypes under conditions, when the genes of the rest of genotype involved to the disease, are fixed. In this connection, the mixed model of inheritance with the "major gene", proposed by Morton and MacLean (1974), is considered, on the basis of which the theoretical expectations of the proportions of the affected sib pairs, sharing the x = 2, 1, 0 haplotypes, identical by descent (IBD) in phenotypic matings with the h = 2, 1, 0 affected parents are derived. Based on the combinatorial analysis of IBD relationships in sib pairs and of the distribution of sibships of any size s greater than or equal to 2 by the numbers L = 2, 3, 4 haplotypes, inherited by s siblings, the empirical assessment of data on sibships of any size with r greater than or equal to 2 affected siblings is considered, which makes it possible to reduce the data observed on distribution of the numbers L in sibships, to that of the IBD relationships in the affected sib pairs. It is also pointed out that conditional probability approach, proposed by the author earlier, allows at the same time to obtain the empirical estimates of the recurrence risks, conditional both on phenotypes of siblings (r affected; s-r normal siblings), and on the number of L haplotypes inherited by sibships. 相似文献
62.
A S Sergeev 《Genetika》1991,27(7):1254-1263
Conditional probability approach in estimation of recurrence risks in sibships of different parental phenotypic matings with the different set of affected and normal siblings is considered. The formulae are presented for calculation of recurrence risks in cases of equal and different susceptibility of two sexes under different ways of sampling of family data: direct selection of offsprings through the parents; indirect selection of offsprings through affected siblings--the probands, under different ascertainment probability--from pi = 1.0 ("exhaustive selection") up to pi----0 ("single selection"); for the case of different susceptibility of the two sexes a possibility of the differences in the ascertainment probabilities of men (pi m) and of women (pi w) is allowed, unlike "independent ascertainment model", which requires the constancy of pi. The case of multiple incompatible subforms is considered for estimation of the recurrence risks of the specified subforms. The methods of the risks estimation proposed are free of genetic models being universal both for classical mendelian traits (with the constant risks) and for multifactorial ones (with variable risks). 相似文献
63.
64.
65.
N D Iushchuk E I Kichik V V Sergeev B A Godovanny? F A Tumanov 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1977,(11):90-94
Comparative study of various methods of treatment was carried out on 777 patients suffering from acute dysentery with a bacteriologically confirmed diagnosis. To assess the therapeutic efficacy, along with consideration of clinical signs of the disease, immunoglobulin level was examined in the blood and coprofiltrates; also the state of reparative processes in the mucosa was appreciated by the histological examination of the biopsy material. Results of the work carried out indicated the inexpediency of the treatment of this disease with a combination of levomycetin and phthalazol. The use of live streptomycin-dependent dysentery vaccine was indicated in protracted torpid dysentery and was of no avail in acute form of the disease. A good therapeutic effect was observed with the application of pathogenetic therapy alone. 相似文献
66.
67.
68.
69.
70.
JB Parentes-Vieira PV Lopes-Costa CG Pires AR dos Santos JD Pereira-Filho BB da Silva 《International Seminars in Surgical Oncology : ISSO》2007,4(1):22