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321.
The objectives of this research are the assessment of secondary effluents (SEs) quality by evaluating chemical parameters and biomarkers. For this purpose, MDA and GSH levels were determined by spectrofotometer. SOD, CAT, and GPX activities were determined by using ELISA kit in the groups of control and the groups exposed to SE. The level of MDA and the activities of SOD in Gammarus pulex vary depending on the exposure time. GSH levels and GSH-PX activities increased in G. pulex exposed to the effluent compared to the control during 24 h and 96 h. CAT activities were in SE group were found lower than the control in G. pulex during 24 h and 96 h. Current experimental results show that SOD, CAT, GPX activities, and GSH and MDA levels in G. pulex are sensitive and appropriate responses for assess the effects of anthropogenic contaminants on the aquatic ecosystems, particularly effluent complex mixtures. 相似文献
322.
Nuray Erkan İdil Can Tunçelli Özkan Özden Serdar Üren 《Zeitschrift fur angewandte Ichthyologie》2020,36(6):906-911
This study attempts to delineate the nutritional value and potential problem of toxic metal contamination in Sardinella maderensis (Lowe,1838) originating from Mauritanian fishery destined for regional common human consumption. Samples caught in Mauritania were delivered to Turkey by ship in 22 days in cold storage. Amino acids, fatty acids and toxic metal analyses of the samples were carried out by using a HPLC (High Performance Liquid Chromatograph), GC (Gas Chromatography) and a ICP-MS (Inductively Coupled Plasma-Mass Spectrometry), respectively. Overall, the range of total Saturated Fatty Acids (SFAs), Monounsaturated Fatty Acids (MUFAs) and Polyunsaturated Fatty Acids (PUFAs) were found to be 34.35%, 28.13% and 34.50%, respectively. In terms of Eicosapentaenoic acid (EPA)+Docosahexaenoic acid (DHA) levels were found to be in total 24.34%. Amino acids content such as glutamic acid, histidine, leucine and lysine were 1735.5, 1,409, 1,580 and 1,710.5 mg/100 g tissue, respectively. Toxic metal levels of Hg, Cd, As, Cr, Mn, Co were determined to reach values between 0.03–4.19 mg/kg. Athough the study is limited, it seems that results on the composition of fatty acids and amino acid, indicate the high nutritional value, well suited for human consumption in particular in terms of omega 3 and essential amino acids. 相似文献
323.
Jacob R. Leistico Priyanka Saini Christopher R. Futtner Miroslav Hejna Yasuhiro Omura Pritin N. Soni Poorva Sandlesh Magdy Milad Jian-Jun Wei Serdar Bulun J. Brandon Parker Grant D. Barish Jun S. Song Debabrata Chakravarti 《Cell reports》2021,34(13):108927
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We review the basic physics involved in transport of ions across membrane channels in cells. Electrochemical forces that control
the diffusion of ions are discussed both from microscopic and macroscopic perspectives. A case is made for use of Brownian
dynamics as the minimal phenomenological model that provides a bridge between experiments and more fundamental theoretical
approaches. Application of Brownian and molecular dynamics methods to channels with known molecular structures is discussed.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
326.
Demet Aydogan Kirmizi Emre Baser Asl Okan Mustafa Kara Ethem Serdar Yalvac Zuleyha Doganyigit 《Experimental Animals》2021,70(1):37
Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress plays a central role in the development of ischemia/reperfusion (IR) injuries. Lycopene (LYC) is a lipophilic, natural carotenoid well known for its antioxidant properties. This study provides information on the potential applications of lycopene. The Wistar Albino rats were distributed into six groups: Sham group (only a laparotomy was performed), Control group [laparotomy and intraperitoneal dissolvent (olive oil)], IR group, IR+olive oil group, IR+LYC 2.5 mg/kg/dose, intraperitoneal group, IR+LYC 5 mg/kg/dose intraperitoneal group. Evaluated in terms of histopathological changes, tissue malondialdehyde levels (MDA), ovarian expressions of phosphorylated nuclear factor-kappa B (p-NF-κB) and the TUNEL method was utilized to show apoptosis of ovarian tissue. There was a significant decrease in MDA, p-NF-κB values and the proportion of apoptotic cells assessed by TUNEL compared to the group that did not receive intraperitoneal LYC in rat injury with IR damage (P<0.05). In histopathological damage scoring, it was observed that the cell damage was significantly reduced in LYC-administered groups. LYC showed significant ameliorative effects on ovary injury caused by IR through acting as an antioxidant, antiinflammatory, and antiapoptotic agent. 相似文献
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328.
Serdar Kabatas Erdin Civelek Ey p Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Gen Tun Akko Erdal Kara z 《World journal of stem cells》2021,13(5):470-484
BACKGROUNDHypoxic-ischemic encephalopathy (HIE) is one of the leading causes of death and long-term neurological impairment in the pediatric population. Despite a limited number of treatments to cure HIE, stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIMTo investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODSThe study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) were intrathecally (IT), intramuscularly (IM), and intravenously administered to participants at a dose of 1 × 106/kg for each administration route twice monthly for 2 mo. In different follow-up durations, the effect of WJ-MSCs administration on HIE, the quality of life, prognosis of patients, and side effects were investigated, and patients were evaluated for neurological, cognitive functions, and spasticity using the Wee Functional Independence Measure (Wee FIM) Scale and Modified Ashworth (MA) Scale. RESULTSFor all participants (n = 6), the mean duration of exposure to hypoxia was 39.17 + 18.82 min, the mean time interval after HIE was 21.83 ± 26.60 mo, the mean baseline Wee FIM scale score was 13.5 ± 0.55, and the mean baseline MA scale score was 35 ± 9.08. Three patients developed only early complications such as low-grade fever, mild headache associated with IT injection, and muscle pain associated with IM injection, all of which were transient and disappeared within 24 h. The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations, electroencephalographies, laboratory tests, and neurological and functional scores of patients. Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up. The mean Wee FIM scale score of participants increased from 13.5 ± 0.55 to 15.17 ± 1.6 points (mean ± SD) at 1 mo (z = - 1.826, P = 0.068) and to 23.5 ± 3.39 points at 12 mo (z = -2.207, P = 0.027) post-treatment. The percentage of patients who achieved an excellent functional improvement (Wee FIM scale total score = 126) increased from 10.71% (at baseline) to 12.03% at 1 mo and to 18.65% at 12 mo post-treatment. CONCLUSIONBoth the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements. The results of this study support conducting further randomized, placebo-controlled studies on this treatment in the pediatric population. 相似文献