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481.
Jacob R. Leistico Priyanka Saini Christopher R. Futtner Miroslav Hejna Yasuhiro Omura Pritin N. Soni Poorva Sandlesh Magdy Milad Jian-Jun Wei Serdar Bulun J. Brandon Parker Grant D. Barish Jun S. Song Debabrata Chakravarti 《Cell reports》2021,34(13):108927
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482.
Concentrations of some radionuclides, including137Cs, in desert truffles in Kuwait were studied and compared with similar samples from other countries in the Middle East, namely
Iran, Egypt, and Tunisia. In addition, sand samples from Kuwait were assayed to calculate the transfer factor of the radionuclides
under consideration. The measured concentrations of40K,226Ra, and137Cs show that137Cs is much higher in Egyptian samples, whereas40K is much lower in samples from Tunisia. The average effective dose equivalent calculated for the Kuwaiti population according
to their diet habits was found to be in the range 0.14-0.23 ΜSv/a. The results are compared with values from other countries. 相似文献
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484.
We review the basic physics involved in transport of ions across membrane channels in cells. Electrochemical forces that control
the diffusion of ions are discussed both from microscopic and macroscopic perspectives. A case is made for use of Brownian
dynamics as the minimal phenomenological model that provides a bridge between experiments and more fundamental theoretical
approaches. Application of Brownian and molecular dynamics methods to channels with known molecular structures is discussed.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
485.
Afzaal Muhammad Saeed Farhan Arshad Muhammad Umair Nadeem Muhammad Tahir Saeed Muhammad Tufail Tabussam 《Probiotics and antimicrobial proteins》2019,11(4):1348-1354
Probiotics and Antimicrobial Proteins - The objective of this work was to explore the effect of two encapsulating polysaccharides (sodium alginate and carrageenan) on the viability of probiotic... 相似文献
486.
Demet Aydogan Kirmizi Emre Baser Asl Okan Mustafa Kara Ethem Serdar Yalvac Zuleyha Doganyigit 《Experimental Animals》2021,70(1):37
Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress plays a central role in the development of ischemia/reperfusion (IR) injuries. Lycopene (LYC) is a lipophilic, natural carotenoid well known for its antioxidant properties. This study provides information on the potential applications of lycopene. The Wistar Albino rats were distributed into six groups: Sham group (only a laparotomy was performed), Control group [laparotomy and intraperitoneal dissolvent (olive oil)], IR group, IR+olive oil group, IR+LYC 2.5 mg/kg/dose, intraperitoneal group, IR+LYC 5 mg/kg/dose intraperitoneal group. Evaluated in terms of histopathological changes, tissue malondialdehyde levels (MDA), ovarian expressions of phosphorylated nuclear factor-kappa B (p-NF-κB) and the TUNEL method was utilized to show apoptosis of ovarian tissue. There was a significant decrease in MDA, p-NF-κB values and the proportion of apoptotic cells assessed by TUNEL compared to the group that did not receive intraperitoneal LYC in rat injury with IR damage (P<0.05). In histopathological damage scoring, it was observed that the cell damage was significantly reduced in LYC-administered groups. LYC showed significant ameliorative effects on ovary injury caused by IR through acting as an antioxidant, antiinflammatory, and antiapoptotic agent. 相似文献
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Serdar Kabatas Erdin Civelek Ey p Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Gen Tun Akko Erdal Kara z 《World journal of stem cells》2021,13(5):470-484
BACKGROUNDHypoxic-ischemic encephalopathy (HIE) is one of the leading causes of death and long-term neurological impairment in the pediatric population. Despite a limited number of treatments to cure HIE, stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIMTo investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODSThe study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) were intrathecally (IT), intramuscularly (IM), and intravenously administered to participants at a dose of 1 × 106/kg for each administration route twice monthly for 2 mo. In different follow-up durations, the effect of WJ-MSCs administration on HIE, the quality of life, prognosis of patients, and side effects were investigated, and patients were evaluated for neurological, cognitive functions, and spasticity using the Wee Functional Independence Measure (Wee FIM) Scale and Modified Ashworth (MA) Scale. RESULTSFor all participants (n = 6), the mean duration of exposure to hypoxia was 39.17 + 18.82 min, the mean time interval after HIE was 21.83 ± 26.60 mo, the mean baseline Wee FIM scale score was 13.5 ± 0.55, and the mean baseline MA scale score was 35 ± 9.08. Three patients developed only early complications such as low-grade fever, mild headache associated with IT injection, and muscle pain associated with IM injection, all of which were transient and disappeared within 24 h. The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations, electroencephalographies, laboratory tests, and neurological and functional scores of patients. Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up. The mean Wee FIM scale score of participants increased from 13.5 ± 0.55 to 15.17 ± 1.6 points (mean ± SD) at 1 mo (z = - 1.826, P = 0.068) and to 23.5 ± 3.39 points at 12 mo (z = -2.207, P = 0.027) post-treatment. The percentage of patients who achieved an excellent functional improvement (Wee FIM scale total score = 126) increased from 10.71% (at baseline) to 12.03% at 1 mo and to 18.65% at 12 mo post-treatment. CONCLUSIONBoth the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements. The results of this study support conducting further randomized, placebo-controlled studies on this treatment in the pediatric population. 相似文献