Die Wirkung von Wetterfronten auf die Nebennierenrinde und die Hoden von Kaninchen

Zusammenfassung Es wurde die Auswirkung von Kalt- und Warmfronten auf die Nebennieren und Hoden von Kaninchen mit histochemische Methoden(Lipoidfärbungen und Phosphataseaktivität) untersucht.Kleine Gruppen von Tieren gleichen Körpergewichts wurden vor und nach dem Durchgang von Wetterfronten getötet.Es wurde festgestellt,dass nach Kaltfronten Zeichen einer Aktivierung und nach Warmfronten Zeichen einer Verminderung der Aktivität der beiden endokrinen Drüsen vorlagen. Es wird betont, dass auch die Hoden durch diese Wetteränderungen betroffen werden.

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The effect of cold and warm fronts on the activity of the adrenal cortex and the testes of rabbits was investigated using histochemical methods. During cold fronts there were signs of increased activity and during warm fronts there were signs of decreased activity of the endocrine function of both organs. The histochemical changes were compared with weather dependent changes in the corticosteroid metabolism as reported by other authors. It is shown that under the given weather conditions the endocrine activity of the testes also undergoes changes.

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Resume On a étudié les répercussions des passages de fronts froids et de fronts chauds sur l'activité des glandes surrénales et des testicules de lapins et cela au moyen de méthodes histologico-chimiques (coloration des lipoïdes et activité phosphatique). On a, pour ce fair,occis de petits groupes de bêtes ayant le même poids. On a constaté qu'après le passage de fronts froids l'activité des deux glandes endocrines avait été augmentée, alors qu'elle était réduite par les fronts chauds.On met ici l'accent sur le fait que l'activité des tisticules est également touchée par les changements de temps.

     

The effect of propranolol on renal sodium handling in patients with cirrhosis

Beta-adrenergic blockade by oral propanolol in five cirrhotic patients caused changes in the handling of an acute sodium load. Fractional sodium excretion following an acute saline load increased from 0.69% +/- 0.29 to 1.49% +/- 0.11 (103 microEq/min +/- 7.5 to 129 microEq/min +/- 18) before propranolol administration. After 3 days of oral propanolol 1 mg/kg day, the fractional excretion of sodium by saline loading increased from 0.52% +/- 0.19 to 2.17 +/- 0.19 (109 microEq/min +/- 9 to 178 microEq/min +/- 11). This change was not accompanied by changes in GFR, RPF or in the renin-aldosterone system. The possibility that these changes are caused by a change in the sodium transport at the tubular cell level induced by the beta-adrenergic blockade, is entertained.     

The india ink phagocytosis by monocytes and granulocytes during acute and chronic consumption coagulopathy]

During generalized intravascular coagulation (GIC) the polimerisation products of fibrinogen are phagocytized by the reticulo-endothelial system of the liver and spleen. Thus an inhibition of the clearance of RES could be detected in a progressed stage of the shock and GIC; this can also be represented by a decrease of India ink storage. In the present work the authors investigate the behavior of monocytes and granulocytes in the peripheral blood in GIC. Approximately 80% of cells will usually phagocytize and concentrate India ink granules, if heparinized blood mixed with India ink is incubated for two hours at 37 degrees C. A decrease of the India ink phagocytosis was detected in 6 patients and in 10 dogs during the shock. This observation corresponds to the behavior of hepatolienal RES during this condition.     

Ultrastructural modifications in the hypophyseal-adrenocortical system in rabbits during experimentally induced parodontosis (author's transl)

During parodontosis induced experimentally by irritation of dental pulp with carbolic acid in rabbits, the participation in the pathological process of adenohypophyseal ACTH-producing cells and of adrenocortical fasciculata cells was studied. Ultrastructural alterations suggesting stimulation of ACTH and glycocorticoid synthesis were observed. The data obtained prove that via afferent pathways to the central nervous system, irritation of the dental pulp induces morphofunctional alterations in the hypothalamo-adenohypophyseal neurosecretory system, by means of functional perturbation of the cerebral cortex leads to hypothalamus (CRF) leads to adenohypophysis (ACTH) leads to adrenal cortex (glucocorticoids)axis.