排序方式: 共有39条查询结果,搜索用时 381 毫秒
21.
Sepehri Javan N. Naderali R. Azad M. Hosseinpour Najafi M. N. 《Plasmonics (Norwell, Mass.)》2019,14(3):579-593
Plasmonics - The semi-analytical solution for the soliton propagation in a suspension consisting of spherical metallic nanoparticles is studied. Considering the impact of imaginary part of... 相似文献
22.
Pooneh Mokarram Mohammed Albokashy Maryam Zarghooni Mohammad Amin Moosavi Zahra Sepehri Qi Min Chen 《Autophagy》2017,13(5):781-819
Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still remains a major life-threatening malignancy. CRC etiology entails both genetic and environmental factors. Macroautophagy/autophagy and the unfolded protein response (UPR) are fundamental mechanisms involved in the regulation of cellular responses to environmental and genetic stresses. Both pathways are interconnected and regulate cellular responses to apoptotic stimuli. In this review, we address the epidemiology and risk factors of CRC, including genetic mutations leading to the occurrence of the disease. Next, we discuss mutations of genes related to autophagy and the UPR in CRC. Then, we discuss how autophagy and the UPR are involved in the regulation of CRC and how they associate with obesity and inflammatory responses in CRC. Finally, we provide perspectives for the modulation of autophagy and the UPR as new therapeutic options for CRC treatment. 相似文献
23.
Javad Zamani Mohammad Ali Hajabbasi Ebrahim Alaie Mozhgan Sepehri Adrian Leuchtmann Rainer Schulin 《International journal of phytoremediation》2016,18(3):278-287
As the depth of soil petroleum contamination can vary substantially under field conditions, a rhizotron experiment was performed to investigate the influence of endophyte, P. indica, on maize growth and degradation of petroleum components in a shallow and a deep-reaching subsurface layer of a soil. For control, a treatment without soil contamination was also included. The degree in contamination and the depth to which it extended had a strong effect on the growth of the plant roots. Contaminated soil layers severely inhibited root growth thus many roots preferred to bypass the shallow contaminated layer and grow in the uncontaminated soil. While the length and branching pattern of these roots were similar to those of uncontaminated treatment. Inoculation of maize with P. indica could improve root distribution and root and shoot growth in all three contamination treatments. This inoculation also enhanced petroleum degradation in soil, especially in the treatment with deep-reaching contamination, consequently the accumulation of petroleum hydrocarbons (PAHs) in the plant tissues were increased. 相似文献
24.
Evidence for a stimulating factor of prolactin and growth hormone secretion present in brewery draff
Aquous extracts of brewery draff injected intravenously into ewes and cows induced prolactin and growth hormone (GH) secretion. The same draff added to the feed of cows appeared to be unable to significantly stimulate the blood level of prolactin and GH. In these experimental conditions, milk production was not enhanced by draff. Pure beta-glucan extracted from barley also stimulated hormone secretion when administered by the intravenous route. Barley, bier and draff therefore contain a beta-glucan-like factor which stimulates lactogenic hormone secretion. The amount present in draff is probably unable to cause an increase in hormones when administered orally. Hence, the well-established stimulatory effect of draff on milk production results from their nutritive value rather than from their ability of modulating the endocrine system. 相似文献
25.
The actinoporins are cytolytic toxins produced by sea anemones. Upon encountering a membrane, preferably containing sphingomyelin, they oligomerize and insert their N-terminal helix into the membrane, forming a pore. Whether sphingomyelin is specifically recognized by the protein or simply induces phase coexistence in the membrane has been debated. Here, we perform multi-microsecond molecular dynamics simulations of an octamer of fragaceatoxin C, a member of the actinoporin family, in lipid bilayers containing either pure 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or a 1:1 mixture of DOPC and palmitoyl sphingomyelin (PSM). The complex is highly stable in both environments, with only slight fraying of the inserted helices near their N-termini. Analyzing the structural parameters of the mixed membrane in the course of the simulation, we see signs of a phase transition for PSM in the inner leaflet of the bilayer. In both leaflets, cross-interactions between lipids of different type decrease over time. Surprisingly, the aromatic loop thought to be responsible for sphingomyelin recognition interacts more with DOPC than PSM by the end of the simulation. These results support the notion that the key membrane property that actinoporins recognize is lipid phase coexistence. 相似文献
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27.
Farzaneh Tavangar Hamid Sepehri Marie Saghaeian Jazi Jahanbakhsh Asadi 《Journal of chemical biology》2017,10(3):143-150
Despite the improvements in cancer treatment, breast cancer still remains the second most common cause of death from cancer in women. Doxorubicin (DOXO) is widely used for cancer treatment. However, drug resistance limits the treatment outcome. Here, we investigated the toxicity of DOXO in combination with an antifungal agent amphotericin B (AmB) against the MCF-7 breast cancer cell line. The cell viability was measured using MTT assay. The apoptosis was studied by caspase-8 and caspase-9 activity measurements and DNA fragmentation was investigated by TUNEL assay. The combination of two drugs significantly increased the apoptotic index and the caspase-8 and caspase-9 activities in comparison to DOXO-treated cells. Our finding showed that pre-treatment of MCF-7 cells with AmB synergistically exerted the anticancer effect of DOXO through the caspase-dependent apoptosis manner. 相似文献
28.
Chromosomal studies in infertile men 总被引:4,自引:0,他引:4
Prometaphase and metaphase chromosome analyses performed on 70 consecutive men with primary infertility (for a period of at least 2 years) revealed 8 (11.42%) men with some kind of chromosomal abnormality. The highest frequency of abnormal karyotypes (10%) was found among patients with azoospermia and the most frequent anomaly was 47, XXY chromosomal constitution, found in 6 (8.57%) patients. All the chromosomal aberrations found in this study, was sex chromosomal type and we did not find any autosomal aberration. All patients with numerical chromosomal anomalies had azoospermia. The incidence of structural aberration in our study was 1.42%. 15 patients had different chromosomal variants (21.38%). We suggest that men with azoospermia should be considered for cytogenetic investigation and we report that "variants of the Y chromosome" have no influence on the sperm count (Million/ml) and fertility of men. 相似文献
29.
Sadaf Rezvanpoor Neda Shakour Nazli Ahangarzadeh Hamid Bakherad Saghi Sepehri Ghazaleh Farhadi Mohammad Hosein Pakdel Mehrdad Iranshahi 《化学与生物多样性》2023,20(5):e202300054
New series of triazole-tetrahydropyrimidinone(thione) hybrids ( 9a – g ) were synthesized. FT-IR, 1H-NMR, 13C-NMR, elemental analysis and mass spectroscopic studies characterized the structures of the synthesized compounds. Then, the synthesized compounds were screened to determine the urease inhibitory activity. Methyl 4-(4-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate ( 9c ) exhibited the highest urease inhibitory activity (IC50=25.02 μM) among the compounds which was almost similar to thiourea as standard (IC50=22.32 μM). The docking study of the screened compounds demonstrated that these compounds fit well in the urease active site. Based on the docking study, compound 9c with the highest urease inhibitory activity showed chelates with both Ni2+ ions of the urease active site. Moreover, the molecular dynamic study of the most potent compounds showed that they created important interactions with the active site flap residues, His322, Cys321, and Met317. 相似文献
30.
H Sepehri C Renard L M Houdebine 《Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)》1990,194(3):193-197
Previous work has shown that various plant extracts administered to animals stimulate milk protein synthesis through the secretion of prolactin. It has also been shown that beta-glucan and pectin are the active molecules capable of stimulating prolactin release in vivo after intravenous injections. In this work, it is shown that beta-glucan and several pectin derivatives are able to stimulate prolactin secretion from hypophysis fragments incubated for 2 hr in a synthetic medium. 相似文献