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Tkachenko PV Bobyntsev II 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2010,96(11):1107-1113
The intrasensory and sensor-effector interactions between inter-spike intervals of acoustic stem-evoked potentials with parameters of hands coordination was found with the help of correlation analysis. Role of excitation of ascending fibres of rostral part of the pons and lateral loop in mechanisms of the auditory-motor coordination was determined. Sex-dependent differences in integration of elements of the sensor-motor system because of lateralization of incoming auditory information and complication of the motor task performed were revealed. In men, mechanisms of auditory-motor coordination have less determined character than in women. That probably determines higher level of bi-manual coordination in men. Optimal correct realization of motor program in men is performed prognostically, while in women--after a mistake has been done. 相似文献
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Alexandre V. Ivachtchenko Eugen B. Frolov Oleg D. Mitkin Sergei E. Tkachenko Ilya M. Okun Alex V. Khvat 《Bioorganic & medicinal chemistry letters》2010,20(1):78-82
Syntheses, biological evaluation, and structure–activity relationships for a series of novel 5-styryl and 5-phenethyl analogs of dimebolin are disclosed. The novel derivatives and dimebolin share a broad spectrum of activities against therapeutically relevant targets. Among all synthesized derivatives, 2,8-dimethyl-5-[(Z)-2-phenylvinyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole and its 5-phenethyl analog are the most potent blockers of 5-HT7, 5-HT6, 5-HT2C, Adrenergic α2 and H1 receptors. The general affinity rank order towards the studied receptors was Z-3(2) > 4(2) ? 4(3) ? dimebolin, all of them having highest affinities to 5-HT7 receptors. 相似文献
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Yu. L. Bakshaev A. V. Bartov P. I. Blinov A. S. Chernenko S. A. Dan’ko Yu. G. Kalinin A. S. Kingsep V. D. Korolev V. I. Mizhiritskiĭ V. P. Smirnov A. Yu. Shashkov P. V. Sasorov S. I. Tkachenko 《Plasma Physics Reports》2007,33(4):259-270
A series of experiments was carried out in the S-300 facility (3 MA, 0.15 Θ, 100 ns) to study the behavior of a section of a magnetically insulated transmission line (MITL) at current densities of up to 500 MA/cm2 and linear current densities of up to 6 MA/cm (i.e., at parameters close to those expected in a fast Z-pinch fusion reactor projected in Sandia National Laboratories). The surface explosion of the ohmically heated MITL electrode is accompanied by the formation of a plasma layer on its surface. This can deteriorate of the transmission properties of the line because the vacuum gap is short-circuited by the plasma produced. The parameters of the electrode plasma and its effect on the MITL transmission properties were investigated experimentally. Possible consequences of the above effects are evaluated, and MHD simulations of the electrode explosion and the subsequent spread of the plasma layer are performed. It is shown that the time during which an MITL segment preserves its transmission properties conforms to the requirements of the conceptual fusion reactor. 相似文献
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Gutierrez E Tkachenko E Besser A Sundd P Ley K Danuser G Ginsberg MH Groisman A 《PloS one》2011,6(9):e23807
Substrate rigidity profoundly impacts cellular behaviors such as migration, gene expression, and cell fate. Total Internal Reflection Fluorescence (TIRF) microscopy enables selective visualization of the dynamics of substrate adhesions, vesicle trafficking, and biochemical signaling at the cell-substrate interface. Here we apply high-refractive-index silicone gels to perform TIRF microscopy on substrates with a wide range of physiological elastic moduli and simultaneously measure traction forces exerted by cells on the substrate. 相似文献
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B I Tkachenko V I Evlakhov I Z Poiasov 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2001,87(5):670-678
Dynamics of the central venous pressure, superior and inferior v. cava flow and venous return following action of pressor stimuli were studied in acute experiments on anaesthetised mongrel cats with artificial lung ventilation and opened chest. The central venous pressure returned to the initial level faster as compared with the dynamics of superior and inferior v. cava flow and venous return. The superior v. cava blood flow increased more than that of inferior v. cava. The data suggest that the central venous pressure is controlled near the lower constant level. 相似文献
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