全文获取类型
收费全文 | 256篇 |
免费 | 35篇 |
出版年
2021年 | 5篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 3篇 |
2015年 | 2篇 |
2014年 | 9篇 |
2013年 | 4篇 |
2012年 | 9篇 |
2011年 | 15篇 |
2010年 | 5篇 |
2009年 | 11篇 |
2008年 | 15篇 |
2007年 | 6篇 |
2006年 | 4篇 |
2005年 | 11篇 |
2004年 | 11篇 |
2003年 | 7篇 |
2002年 | 5篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 6篇 |
1998年 | 4篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 9篇 |
1990年 | 6篇 |
1989年 | 2篇 |
1988年 | 9篇 |
1987年 | 6篇 |
1986年 | 2篇 |
1985年 | 7篇 |
1984年 | 6篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1980年 | 6篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1974年 | 3篇 |
1973年 | 7篇 |
1969年 | 2篇 |
1967年 | 3篇 |
1966年 | 2篇 |
1965年 | 2篇 |
1961年 | 2篇 |
1956年 | 2篇 |
1955年 | 2篇 |
1932年 | 2篇 |
排序方式: 共有291条查询结果,搜索用时 265 毫秒
101.
102.
103.
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE 总被引:17,自引:0,他引:17
下载免费PDF全文
![点击此处可从《American journal of human genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Kyogoku C Langefeld CD Ortmann WA Lee A Selby S Carlton VE Chang M Ramos P Baechler EC Batliwalla FM Novitzke J Williams AH Gillett C Rodine P Graham RR Ardlie KG Gaffney PM Moser KL Petri M Begovich AB Gregersen PK Behrens TW 《American journal of human genetics》2004,75(3):504-507
We genotyped 525 independent North American white individuals with systemic lupus erythematosus (SLE) for the PTPN22 R620W polymorphism and compared the results with data generated from 1,961 white control individuals. The R620W SNP was associated with SLE (genotypic P=.00009), with estimated minor (T) allele frequencies of 12.67% in SLE cases and 8.64% in controls. A single copy of the T allele (W620) increases risk of SLE (odds ratio [OR]=1.37; 95% confidence interval [CI] 1.07-1.75), and two copies of the allele more than double this risk (OR=4.37; 95% CI 1.98-9.65). Together with recent evidence showing association of this SNP with type 1 diabetes and rheumatoid arthritis, these data provide compelling evidence that PTPN22 plays a fundamental role in regulating the immune system and the development of autoimmunity. 相似文献
104.
Williamson AJ Dibling BC Boyne JR Selby P Burchill SA 《The Journal of biological chemistry》2004,279(46):47912-47928
Basic fibroblast growth factor (bFGF) induces cell death in cells of the Ewing's sarcoma family of tumors in vivo and in vitro. In this study we demonstrate that this is dependent on the rapid and sustained activation of p38(MAPK), in contrast to the transient activation of p38(MAPK) associated with bFGF-induced cell proliferation. Stem cell factor-induced survival of TC-32 cells was also associated with transient activation of p38(MAPK). Inhibition of p38(MAPK) by SB202190 and p38(MAPK) small interfering RNA reduces bFGF-induced death in TC-32 cells, consistent with the hypothesis that activation of p38(MAPK) is essential for induction of death by bFGF. This appears to be dependent on sustained activation of p38(MAPK), demonstrated by inhibition of bFGF-induced cell death following addition of SB202190 to TC-32 cells 5 min after exposure to bFGF (20 ng/ml) and activation of p38(MAPK). Prolonged activation of p38(MAPK) is accompanied by a rapid and sustained phosphorylation of Ras and ERK; inhibition of ERK phosphorylation using the MEK-1 inhibitor PD98059 rescued approximately 30% of cells from bFGF-induced death suggesting ERK plays a secondary role in the induction of death. This hypothesis is supported by observations in the A673 cell line; bFGF induced sustained activation of ERK and transient activation of p38(MAPK), which was not associated with cell death. These data demonstrate that sustained activation of p38(MAPK) is essential for activation of the death cascade following exposure of Ewing's sarcoma family of tumors cells to bFGF and provide evidence that activation of p38(MAPK) results in an up-regulation of the death receptor p75(NTR). 相似文献
105.
106.
Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators 总被引:2,自引:0,他引:2
Lahm GP Selby TP Freudenberger JH Stevenson TM Myers BJ Seburyamo G Smith BK Flexner L Clark CE Cordova D 《Bioorganic & medicinal chemistry letters》2005,15(22):4898-4906
A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented. 相似文献
107.
108.
109.
Volume 60, no. 12, p. 4264: Figure 1B should appear as shown below. [This corrects the article on p. 4263 in vol. 60.]. 相似文献
110.
Molecular evolution of a multigene family in group A streptococci 总被引:15,自引:0,他引:15
The emm genes are members of a gene family in group A streptococci (GAS)
that encode for antiphagocytic cell-surface proteins and/or
immunoglobulin-binding proteins. Previously sequenced genes in this family
have been named "emm," "fcrA," "enn," "arp," "protH," and "mrp"; herein
they will be referred to as the "emm gene family." The genes in the emm
family are located in a cluster occupying 3-6 kb between the genes mry and
scpA on the chromosome of Streptococcus pyogenes. Most GAS strains contain
one to three tandemly arranged copies of emm-family genes in the cluster,
but the alleles within the cluster vary among different strains.
Phylogenetic analysis of the conserved sequences at the 3' end of these
genes differentiates all known members of this family into four
evolutionarily distinct emm subfamilies. As a starting point to analyze how
the different subfamilies are related evolutionarily, the structure of the
emm chromosomal region was mapped in a number of diverse GAS strains by
using subfamily-specific primers in the polymerase chain reaction. Nine
distinct chromosomal patterns of the genes in the emm gene cluster were
found. These nine chromosomal patterns support a model for the evolution of
the emm gene family in which gene duplication followed by sequence
divergence resulted in the generation of four major-gene subfamilies in
this locus.
相似文献