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排序方式: 共有258条查询结果,搜索用时 15 毫秒
41.
Frank Riedel Wolfgang H?nle Jürgen G?ske Werner Kachler Ulrich Holzwarth Alexander Schuh 《Biomedizinische Technik》2006,51(1):15-20
INTRODUCTION: Aseptic loosening is the most common problem in total hip arthroplasty (THA). One main aspect is inflammatory reaction against wear particles of the prosthesis materials. Analysing failure mechanisms in THA analysis of the particles and their element distribution of revised granulomatous tissue is essential to improve materials used in THA. MATERIALS AND METHODS: 23 granulomas of revised THA due to aseptic loosening, 13 of which with metal on metal bearing (M/M), were analysed using inductively coupled plasma atomic emission spectrometry (ICP-OES). RESULTS: Elements Cr, Mn, Ni, Al, Cu, Zn, Cd, Ti, V, Zr, Nb and Fe could be detected. The maximum value of Cr was 23.88 ppb (parts per billion), Al 191.02 ppb, Ni 64.95 ppb and Zr 9.96 ppb. The highest value of Al could be found in cementless implants. The maximum value of the elements Cr and Ni could be detected in M/M. In cemented implants the highest value of Zr was found. DISCUSSION: The origin of Zr was the used bone cement in cemented THA. The elements Cr and Ni were significantly higher in M/M bearings. The highest value of Al was detected in granulomas of revised corund rough blasted cementless implants. The histopathologic findings of the revised M/M bearings have been published recently. Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-OES) could not show any differences of the alloying constituents in cases with or without allergic reactions. ICP-OES analysis seems to be not useful examination of histologic sections using SEM with cryotransfer unit. 相似文献
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43.
The intravenous injection of scarlet fever toxin leads to acute changes in the white blood picture. The changes are correlated
to the dose; a small dose causes lymphopenia and granulocytosis, while higher doses are followed by initial granulocytopenia.
Tolerant rabbits do not have granulocytopenia, but lymphopenia persists. Tolerance to the leucopenic effect of the toxin probably
develops somewhat sooner and lasts longer than tolerance to its pyrogenic effect. The blood picture of a cortisone-treated
rabbit after the intravenous injection of scarlet fever toxin resembles the blood picture of a tolerant rabbit. The significance
and associations of these observations are briefly discussed. 相似文献
44.
Retrotransposon BARE-1 and Its Role in Genome Evolution in the Genus Hordeum. 总被引:11,自引:0,他引:11 下载免费PDF全文
CM Vicient A Suoniemi K Anamthawat-Jnsson J Tanskanen A Beharav E Nevo AH Schulman 《The Plant cell》1999,11(9):1769-1784
45.
Schneider A Schuh A Maetzel FK Rückerl R Breitner S Peters A 《International journal of biometeorology》2008,52(6):549-547
Given the accumulating evidence that people with underlying heart disease are a particularly vulnerable group for triggers like changing meteorological parameters, the objective of this longitudinal study was to analyze the influence of weather parameters on blood pressure, arrhythmia and ischemia in cardiovascular patients. A panel study with repeated measurements was conducted in a rehabilitation clinic in Timmendorfer Strand (Baltic Sea, Germany) with 872 cardiovascular patients. Heart rate, blood pressure and electrocardiography changes were measured during repeated bicycle ergometries. Generalized Estimating Equations were used for regression analyses of immediate, delayed and cumulative influences of the daily measured meteorological data. For men, a decrease in air temperature and in water vapor pressure doubled the risk of ST-segment depression during ergometry [odds ratio (OR) for 1 day delay: 1.88 (1.24; 2.83) for air temperature] with a delay of 1-2 days. For women, an increase of their heart rate before the start of the ergometry [same day: 4.36 beats/min (0.99; 7.74) for air temperature] and a 2- to 3-fold higher risk for ventricular ectopic beats [1 day delay: OR 2.43 (1.17; 5.05) for air temperature] was observed with an increase in temperature and water vapor pressure in almost all analyzed time-windows. The study indicates that meteorological parameters can induce changes in heart function which may lead to adverse cardiovascular events especially in susceptible, diseased individuals. The observed effect on ST-segment depression could be a link between the association of weather changes and cardiovascular morbidity and mortality. 相似文献
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47.
Kerly Wollmeister Hofmann Artur Francisco Schumacher Schuh Jonas Saute Raquel Townsend Daniele Fricke Renata Leke Diogo O. Souza Luis Valmor Portela Márcia Lorena Fagundes Chaves Carlos R. M. Rieder 《Neurochemical research》2009,34(8):1401-1404
Several lines of evidence suggest that neuroimmune mechanisms may be involved in the neurodegenerative process of Parkinson’s
disease (PD). Interleukin-6 (IL-6) is increased in the nigrostriatal region and in the cerebrospinal fluid of patients with
PD. IL-6 serum level was evaluated in PD patients. The effects of levodopa treatment and disease severity on IL-6 were also
studied. The IL-6 levels were similar between PD patients (treated and not treated) and controls. However, there was a negative
correlation of IL-6 levels and the activities of daily living scale (P < 0.05), indicating that patients with more severe disease have higher levels of this cytokine. No correlation involving
levodopa treatment and IL-6 serum level was found. The results suggest that only marginal effects of IL-6 occur on the peripheral
immune system, and that the role of IL-6 and others neuroimmune factors needs to be well elucidated on PD. 相似文献
48.
Physiological functions of beneficial elements 总被引:3,自引:0,他引:3
49.
Gordon W Slysz Charles AH Baker Benjamin M Bozsa Anthony Dang Andrew J Percy Melissa Bennett David C Schriemer 《BMC bioinformatics》2009,10(1):162
Background
Hydrogen/deuterium exchange mass spectrometry (H/DX-MS) experiments implemented to characterize protein interaction and protein folding generate large quantities of data. Organizing, processing and visualizing data requires an automated solution, particularly when accommodating new tandem mass spectrometry modes for H/DX measurement. We sought to develop software that offers flexibility in defining workflows so as to support exploratory treatments of H/DX-MS data, with a particular focus on the analysis of very large protein systems and the mining of tandem mass spectrometry data. 相似文献50.
The VASP-Spred-Sprouty domain puzzle 总被引:3,自引:0,他引:3
Sprouty-related proteins with an EVH1 domain (Spreds) belong to a new protein family harboring a conserved N-terminal EVH1 domain, which is related to the VASP (vasodilator-stimulated phosphoprotein) EVH1 domain (Enabled/VASP homology 1 domain) and a C-terminal Sprouty-related domain, typical for Sprouty proteins. Spreds were, like Sproutys, initially discovered as inhibitors of the Ras/MAPK pathway, and the SPR (Sprouty-related) domains of both protein families seem to be very important for many protein interactions and cellular processes. VASP was initially characterized as a proline-rich substrate of protein kinases A and G in human platelets and later shown to be a scaffold protein, regulating both signal transduction pathways and the actin filament system. The VASP-EVH1 domain is known to bind specifically to a FP(4) binding motif, which is, for example, present in the focal adhesion proteins vinculin and zyxin. In this review we give a structural and functional overview on these three protein families and ask whether nature plays a modular protein domain puzzle with stable exchangeable elements or if these closely related domains have various functions when pasted in a different protein context. 相似文献