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61.
62.
Fausto Machicao Andreas Peter Jürgen Machann Ingmar K?nigsrainer Anja B?hm Stefan Zoltan Lutz Martin Heni Andreas Fritsche Fritz Schick Alfred K?nigsrainer Norbert Stefan Hans-Ulrich H?ring Harald Staiger 《PloS one》2016,11(1)
Circadian rhythms govern vital functions. Their disruption provokes metabolic imbalance favouring obesity and type-2 diabetes. The aim of the study was to assess the role of clock genes in human prediabetes. To this end, genotype-phenotype associations of 121 common single nucleotide polymorphisms (SNPs) tagging ARNTL, ARNTL2, CLOCK, CRY1, CRY2, PER1, PER2, PER3, and TIMELESS were assessed in a study population of 1,715 non-diabetic individuals metabolically phenotyped by 5-point oral glucose tolerance tests. In subgroups, hyperinsulinaemic-euglycaemic clamps, intravenous glucose tolerance tests, and magnetic resonance imaging/spectroscopy were performed. None of the tested SNPs was associated with body fat content, insulin sensitivity, or insulin secretion. Four CRY2 SNPs were associated with fasting glycaemia, as reported earlier. Importantly, carriers of these SNPs’ minor alleles revealed elevated fasting glycaemia and, concomitantly, reduced liver fat content. In human liver tissue samples, CRY2 mRNA expression was directly associated with hepatic triglyceride content. Our data may point to CRY2 as a novel switch in hepatic fuel metabolism promoting triglyceride storage and, concomitantly, limiting glucose production. The anti-steatotic effects of the glucose-raising CRY2 alleles may explain why these alleles do not increase type-2 diabetes risk. 相似文献
63.
Dynamic light scattering measurements of the diffusion of probes in filamentous actin solutions 总被引:4,自引:0,他引:4
The diffusion coefficients of monodisperse polystyrene latex spheres in solutions of polymerized actin were measured using dynamic light scattering. Four different probes with radii R, ranging from 50 to 500 nm, were separately used in actin solutions with concentrations c, ranging from 1.5 to 21 microM, which had been polymerized with either 1 mM MgCl2, 1 mM CaCl2, or 100 mM KCl. Under all conditions, and at four different scattering angles in the range of 30 degrees-90 degrees, the measured average diffusion coefficients D of the probes were systematically smaller for samples of increased actin concentration or of increased probe radius. Control experiments indicated that the probes did not bind to the actin. These data for Mg2+- and Ca2+-polymerized actin agree and were found to be quite well summarized by the scaling relation D/D0 = exp[-alpha R delta c nu], where D0 is the measured diffusion coefficient of the probes in water (and, as also measured, in the starting actin solutions prior to polymerization with added salt), with values of delta = 0.73 +/- 0.05, nu = 1.08 +/- 0.09, and alpha = (1.1 +/- 0.6) x 10(-3) (with c in microM and R in nm). Data for KCl-polymerized actin show much more restricted diffusivities of the probes at comparable actin concentrations. Inhomogeneities in the solution are reflected in the "effective polydispersity" of the probe diffusion coefficients, which depend on local microviscosity differences. 相似文献
64.
INORGANIC PYROPHOSPHATASE OF RAT LIVER MITOCHONDRIA : Correlation of Latency with Catalytic Properties and Intramitochondrial Location 总被引:1,自引:0,他引:1 下载免费PDF全文
Stimulation of Mg2+-dependent inorganic pyrophosphatase activity several fold by disruption of mitochondrial membranes does not appreciably alter the catalytic properties of the enzyme. Stimulation is due to increased accessibility of substrate to the enzyme, which is not solublized on activation. The enzyme is attached to the inside of the inner membrane, and under physiological conditions probably hydrolyzes only intramitochondrially-produced PPi. 相似文献
65.
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67.
Schmidt Hoffmann Weickmann v. Berg Heidt Scherz Kuckuck R. Schick Gustaf de Lattin Hilde Pieper Schwanitz Hassebrauk Roegner-Aust Schröck H. -J. Troll Stelzner Hackbarth Grub P. van Veen R. W. Böhme E. Stein 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1942,14(2):47-56
Ohne Zusammenfassung 相似文献
68.
v. Witsch Freisleben Wulff F. Schwanitz A. Th. Czaja Schmidt Karl Paech Fuchs H. Stubbe Lein R. Schick Hoffmann Schröck Sessous 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1942,14(6):146-152
Ohne Zusammenfassung 相似文献
69.
Freisleben Weickmann Ernst Eckhard Kuhn F. Resende Straub Schmidt E. Stein J. Straub Heberer H. Ernst Hilde Pieper W. J. Schmidt J. Kisser H. -J. Troll R. Schick Eifrig Aust Schröck Stelzner Schröck Schieblich R. Schick Schwanitz Hilde Pieper Gruber Lang 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1941,13(4):88-96
Ohne Zusammenfassung 相似文献
70.
Ernst Hoffmann v. Berg Propach Stubbe E. Stein Hilde Pieper Stelzner Schick Freisleben Schieblich Hackbarth v. Rauch Scherz Zwintzscher 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1940,12(10):249-256
Ohne Zusammenfassung 相似文献